{"id":"https://openalex.org/W2045309744","doi":"https://doi.org/10.1038/bjc.1998.632","title":"p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma","display_name":"p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2045309744","doi":"https://doi.org/10.1038/bjc.1998.632","mag":"2045309744","pmid":"https://pubmed.ncbi.nlm.nih.gov/9792155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2063151"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.1998.632","doi":"https://doi.org/10.1038/bjc.1998.632","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1998.632","pdf_url":"https://www.nature.com/articles/bjc1998632.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/bjc1998632.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044097329","display_name":"Hiroyuki Mineta","orcid":"https://orcid.org/0000-0002-7496-3489","observed_orcids":["https://orcid.org/0000-0002-7496-3489"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H Mineta","raw_affiliation_strings":["Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033640021","display_name":"\u00c5ke Borg","orcid":"https://orcid.org/0000-0002-5793-132X","observed_orcids":["https://orcid.org/0000-0002-5793-132X"]},"institutions":[{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["JP","SE"],"is_corresponding":false,"raw_author_name":"\u00c5 Borg","raw_affiliation_strings":["Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","2Department of Otorhinolaryngology. Hamamatsu University School of Medicine. 3600 Handa-cho. Hamamatsu-city, Japan; Departments of 30ncology and 4Patoogy","University Hospital. Lund. Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"2Department of Otorhinolaryngology. Hamamatsu University School of Medicine. 3600 Handa-cho. Hamamatsu-city, Japan; Departments of 30ncology and 4Patoogy","institution_ids":["https://openalex.org/I3123035732"]},{"raw_affiliation_string":"University Hospital. Lund. Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110055733","display_name":"Michael R. Dictor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"M Dictor","raw_affiliation_strings":["Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Wahlberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P Wahlberg","raw_affiliation_strings":["Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038871228","display_name":"Jan \u00c5kervall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J \u00c5kervall","raw_affiliation_strings":["Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090660663","display_name":"Johan Wennerberg","orcid":"https://orcid.org/0000-0002-9589-7935","observed_orcids":["https://orcid.org/0000-0002-9589-7935"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J Wennerberg","raw_affiliation_strings":["Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology/H&N Surgery, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110055733"],"corresponding_institution_ids":["https://openalex.org/I4210137844"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":6.3491,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.96505299,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"78","issue":"8","first_page":"1084","last_page":"1090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0658000037074089,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/p53-overexpression","display_name":"p53 overexpression","score":0.9120000004768372},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.75},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cause-specific-survival","display_name":"cause-specific survival","score":0.7059999704360962},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7739999890327454},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.6629999876022339},{"id":"https://openalex.org/keywords/nonsense-mutation","display_name":"nonsense mutation","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.7054659128189087},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6588049530982971},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6499872207641602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6377332806587219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5487082004547119},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5323315858840942},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5181692838668823},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.5144505500793457},{"id":"https://openalex.org/C129219603","wikidata":"https://www.wikidata.org/wiki/Q1788683","display_name":"Single-strand conformation polymorphism","level":4,"score":0.48496270179748535},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.47939586639404297},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42774802446365356},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4101119935512543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.407815158367157},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26468729972839355},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.24011453986167908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22308388352394104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18919157981872559},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11272096633911133}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/bjc.1998.632","doi":"https://doi.org/10.1038/bjc.1998.632","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1998.632","pdf_url":"https://www.nature.com/articles/bjc1998632.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2063151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2063151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:9792155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9792155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/bjc.1998.632","doi":"https://doi.org/10.1038/bjc.1998.632","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1998.632","pdf_url":"https://www.nature.com/articles/bjc1998632.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045309744.pdf","grobid_xml":"https://content.openalex.org/works/W2045309744.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W253170533","https://openalex.org/W273190045","https://openalex.org/W1485195428","https://openalex.org/W1545495395","https://openalex.org/W1552426876","https://openalex.org/W1847864430","https://openalex.org/W1979171324","https://openalex.org/W1981180996","https://openalex.org/W1997646834","https://openalex.org/W2004074465","https://openalex.org/W2008301561","https://openalex.org/W2010714811","https://openalex.org/W2013516256","https://openalex.org/W2018109748","https://openalex.org/W2019283533","https://openalex.org/W2025841318","https://openalex.org/W2037268137","https://openalex.org/W2039382131","https://openalex.org/W2050930678","https://openalex.org/W2059814410","https://openalex.org/W2060786724","https://openalex.org/W2065169702","https://openalex.org/W2066383350","https://openalex.org/W2075899910","https://openalex.org/W2085873670","https://openalex.org/W2094731479","https://openalex.org/W2095708057","https://openalex.org/W2096276671","https://openalex.org/W2099907467","https://openalex.org/W2102383139","https://openalex.org/W2108197743","https://openalex.org/W2110836068","https://openalex.org/W2123754647","https://openalex.org/W2129797996","https://openalex.org/W2139785994","https://openalex.org/W2149805689","https://openalex.org/W2150097377","https://openalex.org/W2223163871","https://openalex.org/W2341209396","https://openalex.org/W2411308901","https://openalex.org/W2416350050"],"related_works":["https://openalex.org/W2266999676","https://openalex.org/W1975956256","https://openalex.org/W2092585633","https://openalex.org/W2997797347","https://openalex.org/W2017627639","https://openalex.org/W2978751908","https://openalex.org/W2055224180","https://openalex.org/W2036421802","https://openalex.org/W4315434176","https://openalex.org/W2013516256"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}