{"id":"https://openalex.org/W2045256808","doi":"https://doi.org/10.1016/0002-8703(91)90877-k","title":"The effect of doxazosin on platelet aggregation in normotensive subjects and patients with hypertension: An in vitro study","display_name":"The effect of doxazosin on platelet aggregation in normotensive subjects and patients with hypertension: An in vitro study","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2045256808","doi":"https://doi.org/10.1016/0002-8703(91)90877-k","mag":"2045256808","pmid":"https://pubmed.ncbi.nlm.nih.gov/1824665"},"language":"en","primary_location":{"id":"doi:10.1016/0002-8703(91)90877-k","doi":"https://doi.org/10.1016/0002-8703(91)90877-k","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-8703(91)90877-k","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103641996","display_name":"Rafael Hern\u00e1ndez Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rafael Hernandez Hernandez","raw_affiliation_strings":["School of Medicine, Centro Occidental Lisandro Alvarado, Barquisimeto, Venezuela","School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Centro Occidental Lisandro Alvarado, Barquisimeto, Venezuela","institution_ids":[]},{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111637533","display_name":"Atiff Rafael Carvajal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atiff Rafael Carvajal","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056591109","display_name":"Jaime Pajuelo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaime Guerrero Pajuelo","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112645116","display_name":"Mar\u00eda Jos\u00e9 Armas-Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Jose Armas de Hernandez","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043794485","display_name":"Mar\u00eda Cristina Armas Padilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Cristina Armas Padilla","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078464532","display_name":"Oscar Barragan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oscar Barragan","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010420612","display_name":"J Boada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose Jesus Boada Boada","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030742473","display_name":"Emir Roa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emir Roa","raw_affiliation_strings":["School of Medicine Barquisimeto, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine Barquisimeto, Venezuela","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103641996"],"corresponding_institution_ids":[],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":1.0535,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"121","issue":"1","first_page":"389","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxazosin","display_name":"doxazosin","score":1.0},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.8100000023841858},{"id":"https://openalex.org/keywords/epinephrine-induced-aggregation","display_name":"epinephrine-induced aggregation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/collagen-induced-platelet-aggregation","display_name":"collagen-induced aggregation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/adp-induced-platelet-aggregation","display_name":"ADP-induced aggregation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.7860000133514404},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2777590997","wikidata":"https://www.wikidata.org/wiki/Q419939","display_name":"Doxazosin","level":3,"score":0.9959820508956909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8674848079681396},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7534682154655457},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.7251807451248169},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6863517761230469},{"id":"https://openalex.org/C2777399203","wikidata":"https://www.wikidata.org/wiki/Q185253","display_name":"Adenosine diphosphate","level":4,"score":0.6351515054702759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6207762956619263},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.6014792323112488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5212593674659729},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5003774166107178},{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.4754621386528015},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.46474358439445496},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45237526297569275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14297136664390564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08353778719902039}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017292","descriptor_name":"Doxazosin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0002-8703(91)90877-k","doi":"https://doi.org/10.1016/0002-8703(91)90877-k","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-8703(91)90877-k","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},{"id":"pmid:1824665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1824665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American heart journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1987426214","https://openalex.org/W2012214760","https://openalex.org/W2038334945","https://openalex.org/W2039935433","https://openalex.org/W2055210973","https://openalex.org/W2061646861","https://openalex.org/W2064572313","https://openalex.org/W2093255760","https://openalex.org/W2416273467","https://openalex.org/W2421339733","https://openalex.org/W2439282338","https://openalex.org/W4233794581","https://openalex.org/W4285719527","https://openalex.org/W4322696924"],"related_works":["https://openalex.org/W2007750423","https://openalex.org/W2082353950","https://openalex.org/W2064272919","https://openalex.org/W2035284330","https://openalex.org/W7029178064","https://openalex.org/W2055876099","https://openalex.org/W2019510838","https://openalex.org/W2071910484","https://openalex.org/W207721792","https://openalex.org/W7018706970"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}