{"id":"https://openalex.org/W2045234723","doi":"https://doi.org/10.1038/sj.npp.1301074","title":"Caspase-3 Activation in Rat Frontal Cortex Following Treatment with Typical and Atypical Antipsychotics","display_name":"Caspase-3 Activation in Rat Frontal Cortex Following Treatment with Typical and Atypical Antipsychotics","publication_year":2006,"publication_date":"2006-04-12","ids":{"openalex":"https://openalex.org/W2045234723","doi":"https://doi.org/10.1038/sj.npp.1301074","mag":"2045234723","pmid":"https://pubmed.ncbi.nlm.nih.gov/16641945"},"language":"en","primary_location":{"id":"doi:10.1038/sj.npp.1301074","doi":"https://doi.org/10.1038/sj.npp.1301074","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.npp.1301074","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029626538","display_name":"L. Fredrik Jarskog","orcid":"https://orcid.org/0000-0001-6296-3767","observed_orcids":["https://orcid.org/0000-0001-6296-3767"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L Fredrik Jarskog","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA. jarskog@med.unc.edu","Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA. jarskog@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052698941","display_name":"John H. Gilmore","orcid":"https://orcid.org/0000-0002-0939-6764","observed_orcids":["https://orcid.org/0000-0002-0939-6764"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H Gilmore","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Schizophrenia Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Schizophrenia Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027530270","display_name":"Leisa A. Glantz","orcid":"https://orcid.org/0000-0002-4874-9163","observed_orcids":["https://orcid.org/0000-0002-4874-9163"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leisa A Glantz","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Schizophrenia Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Schizophrenia Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002658085","display_name":"Karissa Gable","orcid":"https://orcid.org/0000-0003-2777-7277","observed_orcids":["https://orcid.org/0000-0003-2777-7277"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karissa L Gable","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020602060","display_name":"Thomas T. German","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas T German","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085197313","display_name":"Ruth I Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth I Tong","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075093461","display_name":"Jeffrey Alan Lieberman","orcid":"https://orcid.org/0000-0002-1899-1776","observed_orcids":["https://orcid.org/0000-0002-1899-1776"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A Lieberman","raw_affiliation_strings":["Department of Psychiatry, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029626538"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":2.2348,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.86195744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"1","first_page":"95","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.890999972820282},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8930000066757202},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.8679999709129333},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":1.0},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.843999981880188},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9779999852180481},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9819999933242798},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.972000002861023},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/chronic-antipsychotic-treatment","display_name":"chronic antipsychotic treatment","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.7838202714920044},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.6279141902923584},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5158940553665161},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.514865517616272},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.45712393522262573},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.4539222717285156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44920575618743896},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.44655436277389526},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4357125163078308},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40749549865722656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34329357743263245},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34094685316085815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3332749605178833},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.258436381816864},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.23704621195793152},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19035160541534424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12783536314964294},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.10299301147460938}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.npp.1301074","doi":"https://doi.org/10.1038/sj.npp.1301074","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.npp.1301074","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmid:16641945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16641945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5538327953","display_name":null,"funder_award_id":"MH-01752","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G656874027","display_name":"Bcl-2 Family Protein and Apoptosis in Schizophrenia","funder_award_id":"K08MH001752","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W174450192","https://openalex.org/W1540436551","https://openalex.org/W1892554314","https://openalex.org/W1966550713","https://openalex.org/W1971646855","https://openalex.org/W1979551767","https://openalex.org/W1979700184","https://openalex.org/W1981307526","https://openalex.org/W1984992452","https://openalex.org/W1985994929","https://openalex.org/W1988346923","https://openalex.org/W1994517931","https://openalex.org/W2010230693","https://openalex.org/W2015009245","https://openalex.org/W2017140635","https://openalex.org/W2018742347","https://openalex.org/W2018851857","https://openalex.org/W2020478383","https://openalex.org/W2030564379","https://openalex.org/W2033003961","https://openalex.org/W2041990601","https://openalex.org/W2044980193","https://openalex.org/W2045309540","https://openalex.org/W2053640261","https://openalex.org/W2060290761","https://openalex.org/W2066396973","https://openalex.org/W2071532773","https://openalex.org/W2072310161","https://openalex.org/W2077669223","https://openalex.org/W2110921107","https://openalex.org/W2111988981","https://openalex.org/W2115084880","https://openalex.org/W2120105093","https://openalex.org/W2120573105","https://openalex.org/W2121640875","https://openalex.org/W2126549748","https://openalex.org/W2127679160","https://openalex.org/W2129104604","https://openalex.org/W2134979684","https://openalex.org/W2145240519","https://openalex.org/W2156026059","https://openalex.org/W2244063038"],"related_works":["https://openalex.org/W4385743638","https://openalex.org/W2111988981","https://openalex.org/W2043755455","https://openalex.org/W2966583622","https://openalex.org/W2021952628","https://openalex.org/W2792824578","https://openalex.org/W2145993791","https://openalex.org/W2964490396","https://openalex.org/W2016781419","https://openalex.org/W2964580393"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}