{"id":"https://openalex.org/W2045220433","doi":"https://doi.org/10.1021/bi00496a018","title":"Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart","display_name":"Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W2045220433","doi":"https://doi.org/10.1021/bi00496a018","mag":"2045220433","pmid":"https://pubmed.ncbi.nlm.nih.gov/2176866"},"language":"en","primary_location":{"id":"doi:10.1021/bi00496a018","doi":"https://doi.org/10.1021/bi00496a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00496a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033107266","display_name":"Hai Le Trong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Le Trong","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109927272","display_name":"Norbert Beier","orcid":"https://orcid.org/0000-0001-8292-5928","observed_orcids":["https://orcid.org/0000-0001-8292-5928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert Beier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108494434","display_name":"William K. Sonnenburg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William K. Sonnenburg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043192773","display_name":"Steven D. Stroop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven D. Stroop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108367608","display_name":"Kenneth A. Walsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth A. Walsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112194362","display_name":"Joseph A. Beavo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph A. Beavo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005668168","display_name":"Harry Charbonneau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry Charbonneau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9956,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.86790417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"29","issue":"44","first_page":"10280","last_page":"10288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-nucleotide-phosphodiesterase","display_name":"cyclic nucleotide phosphodiesterase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bovine-heart","display_name":"bovine heart","score":0.9390000104904175},{"id":"https://openalex.org/keywords/amino-acid-sequence","display_name":"amino acid sequence","score":0.9210000038146973},{"id":"https://openalex.org/keywords/catalytic-domain","display_name":"catalytic domain","score":0.6909999847412109},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/homodimer","display_name":"homodimer","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.7960000038146973},{"id":"https://openalex.org/keywords/protein-structure-evolution","display_name":"protein structure evolution","score":0.4259999990463257},{"id":"https://openalex.org/keywords/cdna","display_name":"cDNA","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6931719779968262},{"id":"https://openalex.org/C3020139451","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic gmp","level":3,"score":0.6717849969863892},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6506164073944092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5491110682487488},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5482960939407349},{"id":"https://openalex.org/C2780215583","wikidata":"https://www.wikidata.org/wiki/Q946700","display_name":"Cyclic nucleotide phosphodiesterase","level":4,"score":0.49820542335510254},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4927573502063751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4866226613521576},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.4851296842098236},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4252849221229553},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27186423540115356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09468004107475281}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00496a018","doi":"https://doi.org/10.1021/bi00496a018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00496a018","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:2176866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2176866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G159685103","display_name":null,"funder_award_id":"DK 21723","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2284422105","display_name":"Metabolism and Function of Cyclic Nucleotides","funder_award_id":"R01DK021723","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3910507202","display_name":null,"funder_award_id":"EY 08197","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G455733191","display_name":null,"funder_award_id":"GM-15731","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5475518267","display_name":"PROTEIN STUCTURE--DOMAINS AND REGULATION OF CD45","funder_award_id":"5r01gm015731-26","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G814996238","display_name":"PHOTORECEPTOR PHOSPHODIESTERASE STRUCTURE/FUNCTION","funder_award_id":"5r01ey008197-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1030517862","https://openalex.org/W1232330100","https://openalex.org/W1483147897","https://openalex.org/W1484500255","https://openalex.org/W1518942907","https://openalex.org/W1519694171","https://openalex.org/W1527689406","https://openalex.org/W1551150403","https://openalex.org/W1559386011","https://openalex.org/W1869250499","https://openalex.org/W1967647423","https://openalex.org/W1971168940","https://openalex.org/W1974605099","https://openalex.org/W1977118713","https://openalex.org/W1979814124","https://openalex.org/W1987787946","https://openalex.org/W2000914178","https://openalex.org/W2014689788","https://openalex.org/W2014770523","https://openalex.org/W2017784139","https://openalex.org/W2030636433","https://openalex.org/W2046608233","https://openalex.org/W2047549229","https://openalex.org/W2058966982","https://openalex.org/W2071331983","https://openalex.org/W2078517595","https://openalex.org/W2094031081","https://openalex.org/W2099375764","https://openalex.org/W2138270253","https://openalex.org/W2140507020","https://openalex.org/W2148613563","https://openalex.org/W2153477621","https://openalex.org/W2421955228"],"related_works":["https://openalex.org/W2099375764","https://openalex.org/W2408587109","https://openalex.org/W2046608233","https://openalex.org/W4320800855","https://openalex.org/W100599044","https://openalex.org/W1977118713","https://openalex.org/W1550275201","https://openalex.org/W2021586559","https://openalex.org/W4250368808","https://openalex.org/W2037908999"],"abstract_inverted_index":{"The":[0,45,68],"complete":[1],"amino":[2],"acid":[3],"sequence":[4],"of":[5,14,22,25,29,39,50,57,66,73,89,112,118,135],"the":[6,26,30,40,74,113,119,132,136,168,174],"cyclic":[7,10,156],"GMP":[8],"stimulated":[9],"nucleotide":[11,157],"phosphodiesterase":[12,85],"(cGS-PDE)":[13],"bovine":[15],"heart":[16],"has":[17,34],"been":[18,35],"determined":[19],"by":[20,37,182],"analysis":[21],"five":[23],"digests":[24],"protein;":[27],"placement":[28],"C-terminal":[31,69],"330":[32],"residues":[33,71,105],"confirmed":[36],"interpretation":[38],"corresponding":[41,110],"partial":[42],"cDNA":[43],"clone.":[44],"holoenzyme":[46],"is":[47,81,107,129],"a":[48,62,77,96,161],"homodimer":[49],"two":[51,142],"identical":[52],"N":[53],"alpha-acetylated":[54],"polypeptide":[55],"chains":[56],"921":[58],"residues,":[59],"each":[60],"with":[61],"calculated":[63],"molecular":[64],"weight":[65],"103,244.":[67],"region,":[70,104],"613-871,":[72],"cGS-PDE":[75],"comprises":[76],"catalytic":[78,169],"domain":[79,124,140],"that":[80,147,167],"conserved":[82,103,123],"in":[83,131],"all":[84],"sequences":[86],"except":[87],"those":[88],"PDE":[90,98],"1":[91],"from":[92,99,150],"Saccharomyces":[93],"cerevisiae":[94],"and":[95,115,128,160,170,176],"secreted":[97],"Dictyostelium.":[100],"A":[101],"second":[102],"209-567,":[106],"homologous":[108],"to":[109],"regions":[111],"alpha":[114],"alpha'":[116],"subunits":[117],"photoreceptor":[120,177],"phosphodiesterases.":[121],"This":[122,138],"specifically":[125],"binds":[126],"cGMP":[127],"involved":[130],"allosteric":[133],"regulation":[134],"cGS-PDE.":[137],"regulatory":[139,171],"contains":[141],"tandem,":[143],"internal":[144,185],"repeats,":[145],"suggesting":[146],"it":[148],"evolved":[149],"an":[151,183],"ancestral":[152],"gene":[153,186],"duplication.":[154,187],"Common":[155],"binding":[158],"properties":[159],"distant":[162],"structural":[163],"relationship":[164],"provide":[165],"evidence":[166],"domains":[172],"within":[173],"cGS-":[175],"PDEs":[178],"are":[179],"also":[180],"related":[181],"ancient":[184]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}