{"id":"https://openalex.org/W2045139779","doi":"https://doi.org/10.1080/1462220021000032780","title":"Evaluating acute effects of potential reduced-exposure products for smokers: Clinical laboratory methodology","display_name":"Evaluating acute effects of potential reduced-exposure products for smokers: Clinical laboratory methodology","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2045139779","doi":"https://doi.org/10.1080/1462220021000032780","mag":"2045139779","pmid":"https://pubmed.ncbi.nlm.nih.gov/12573174"},"language":"en","primary_location":{"id":"doi:10.1080/1462220021000032780","doi":"https://doi.org/10.1080/1462220021000032780","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1462220021000032780","pdf_url":null,"source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & Tobacco Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000102661","display_name":"Alison B. Breland","orcid":"https://orcid.org/0000-0001-8949-2395","observed_orcids":["https://orcid.org/0000-0001-8949-2395"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Breland","raw_affiliation_strings":["Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113864665","display_name":"August R. Buchhalter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"August Buchhalter","raw_affiliation_strings":["Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071397479","display_name":"Sarah E. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Evans","raw_affiliation_strings":["Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064551545","display_name":"Thomas Eissenberg","orcid":"https://orcid.org/0000-0002-8277-5437","observed_orcids":["https://orcid.org/0000-0002-8277-5437"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Eissenberg","raw_affiliation_strings":["Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":5392,"currency":"USD","value_usd":5392},"apc_paid":null,"fwci":4.4677,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.94092879,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"131","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/harm-reduction","display_name":"harm reduction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nicotine-withdrawal","display_name":"nicotine withdrawal","score":0.5370000004768372},{"id":"https://openalex.org/keywords/plasma-nicotine-concentration","display_name":"plasma nicotine concentration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/puffing-behavior","display_name":"puffing behavior","score":0.7940000295639038},{"id":"https://openalex.org/keywords/acute-effects-of-smoking","display_name":"acute effects of smoking","score":0.6129999756813049},{"id":"https://openalex.org/keywords/tobacco-smoke-constituents","display_name":"tobacco smoke constituents","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7060734629631042},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6525787711143494},{"id":"https://openalex.org/C3020384764","wikidata":"https://www.wikidata.org/wiki/Q44106","display_name":"Tobacco product","level":2,"score":0.618229329586029},{"id":"https://openalex.org/C529928208","wikidata":"https://www.wikidata.org/wiki/Q1458711","display_name":"Harm reduction","level":3,"score":0.5971498489379883},{"id":"https://openalex.org/C58874564","wikidata":"https://www.wikidata.org/wiki/Q130768","display_name":"Smoke","level":2,"score":0.5057497024536133},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.45732417702674866},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4167792797088623},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3646244406700134},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3291465640068054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2997499704360962},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.18081894516944885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08444339036941528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07116925716400146},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074606","descriptor_name":"Smoking Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016540","descriptor_name":"Smoking Cessation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/1462220021000032780","doi":"https://doi.org/10.1080/1462220021000032780","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1462220021000032780","pdf_url":null,"source":{"id":"https://openalex.org/S62426309","display_name":"Nicotine & Tobacco Research","issn_l":"1462-2203","issn":["1462-2203","1469-994X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & Tobacco Research","raw_type":"journal-article"},{"id":"pmid:12573174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12573174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2225205159","display_name":null,"funder_award_id":"F31 DA06052-01","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3402941392","display_name":"GENDER &NICOTINE WITHDRAWAL--A PLACEBO CONTROL STUDY","funder_award_id":"F31DA006052","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4500043528","display_name":"DRUG CRAVING--PHARMACOLOGIC AND ASSOCIATIVE INFLUENCES","funder_award_id":"R29DA011082","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5966678231","display_name":"General Clinical Research Center","funder_award_id":"M01RR000065","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8988406653","display_name":"CENTER FOR DRUG ABUSE RESEARCH","funder_award_id":"P50DA005274","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W32456633","https://openalex.org/W1481725542","https://openalex.org/W1765904139","https://openalex.org/W1867647480","https://openalex.org/W1949622963","https://openalex.org/W1965841383","https://openalex.org/W1968627925","https://openalex.org/W1971947229","https://openalex.org/W1974132634","https://openalex.org/W1982754409","https://openalex.org/W1983801938","https://openalex.org/W1994585295","https://openalex.org/W1999912466","https://openalex.org/W2024628954","https://openalex.org/W2026115971","https://openalex.org/W2028669370","https://openalex.org/W2032285175","https://openalex.org/W2039460330","https://openalex.org/W2040959518","https://openalex.org/W2045100306","https://openalex.org/W2052492048","https://openalex.org/W2072496032","https://openalex.org/W2078519449","https://openalex.org/W2101324933","https://openalex.org/W2102516237","https://openalex.org/W2110569081","https://openalex.org/W2126153666","https://openalex.org/W2139203866","https://openalex.org/W2148747028","https://openalex.org/W2161174064","https://openalex.org/W2167786935","https://openalex.org/W2411689377","https://openalex.org/W4250145181","https://openalex.org/W4323282248"],"related_works":["https://openalex.org/W2113369309","https://openalex.org/W2106796593","https://openalex.org/W1987452165","https://openalex.org/W824208794","https://openalex.org/W2106457238","https://openalex.org/W2133517629","https://openalex.org/W2136374974","https://openalex.org/W2072028872","https://openalex.org/W2154878237","https://openalex.org/W2057685298"],"abstract_inverted_index":{"Harm":[0],"reduction":[1,22],"for":[2,48,55,230],"tobacco":[3,111],"smokers":[4,70,231],"may":[5],"involve":[6,30],"reducing":[7],"their":[8],"exposure":[9,17],"to":[10,42,160,224],"lethal":[11],"smoke":[12,15],"constituents.":[13],"Assessing":[14],"constituent":[16],"and":[18,33,60,103,118,125,133,136,140,154,170,185,192,202,232],"any":[19],"resulting":[20],"harm":[21],"from":[23],"a":[24,44],"potential":[25],"reduced-exposure":[26,228],"product":[27,106,229],"(PREP)":[28],"will":[29],"preclinical,":[31],"clinical,":[32],"epidemiological":[34],"research.":[35],"The":[36],"purpose":[37],"of":[38,53,156],"this":[39,234],"study":[40],"was":[41,130,149,164],"evaluate":[43],"clinical":[45,235],"laboratory":[46,236],"model":[47,237],"assessing":[49],"the":[50,152,176],"acute":[51],"effects":[52],"PREPs":[54],"smokers.":[56],"Philip":[57],"Morris'":[58],"Accord":[59,163,219],"R.J.":[61],"Reynolds'":[62],"Eclipse":[63,188,221],"were":[64,96,122,143],"used":[65],"as":[66],"examples.":[67],"Twenty":[68],"overnight-abstinent":[69],"(>":[71],"15":[72],"'light'":[73],"or":[74,114],"'ultra-light'":[75],"cigarettes/day)":[76],"participated":[77],"in":[78,84],"4":[79],"Latin-square":[80],"ordered,":[81],"2.5-hr":[82],"sessions":[83],"which":[85],"they":[86],"completed":[87],"an":[88,226],"8-puff":[89],"smoking":[90],"bout":[91],"every":[92],"30":[93],"minutes.":[94],"Sessions":[95],"separated":[97],"by":[98,105,196],"at":[99,151,167],"least":[100],"24":[101],"hours":[102],"differed":[104],"used:":[107],"own":[108],"brand,":[109,200],"denicotinized":[110,206],"cigarettes,":[112,162,207],"Accord,":[113,181,201],"Eclipse.":[115],"Tobacco":[116],"withdrawal":[117,169,190],"carbon":[119],"monoxide":[120],"(CO)":[121],"assessed":[123,131,144],"before":[124,132],"after":[126],"smoking,":[127,135],"heart":[128],"rate":[129],"during":[134],"puff":[137],"volume,":[138],"duration,":[139],"interpuff":[141],"interval":[142],"while":[145],"subjects":[146,182],"smoked.":[147],"Blood":[148],"sampled":[150],"beginning":[153],"end":[155],"each":[157],"session.":[158],"Relative":[159],"normal":[161],"less":[165],"effective":[166,227],"suppressing":[168],"produced":[171],"minimal":[172],"CO":[173,194],"boost":[174,195],"despite":[175],"fact":[177],"that,":[178],"when":[179],"using":[180],"took":[183],"bigger":[184],"longer":[186],"puffs.":[187],"suppressed":[189],"fully":[191],"increased":[193,208],"approximately":[197],"30%.":[198],"Own":[199],"Eclipse,":[203],"but":[204],"not":[205],"plasma":[209],"nicotine":[210],"concentration.":[211],"Taken":[212],"together,":[213],"these":[214],"results":[215],"suggest":[216],"that":[217,233],"neither":[218],"nor":[220],"is":[222,238],"likely":[223],"be":[225],"valuable.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}