{"id":"https://openalex.org/W2045127657","doi":"https://doi.org/10.1007/bf00499104","title":"Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3?, 5?-adenosine monophosphate concentrations of rat striatum","display_name":"Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3?, 5?-adenosine monophosphate concentrations of rat striatum","publication_year":1974,"publication_date":"1974-01-01","ids":{"openalex":"https://openalex.org/W2045127657","doi":"https://doi.org/10.1007/bf00499104","mag":"2045127657","pmid":"https://pubmed.ncbi.nlm.nih.gov/4375258"},"language":"en","primary_location":{"id":"doi:10.1007/bf00499104","doi":"https://doi.org/10.1007/bf00499104","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00499104","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001553484","display_name":"Hermann J. Gerhards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. J. Gerhards","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012546573","display_name":"Angelo Carenzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Carenzi","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051515082","display_name":"E. Costa","orcid":"https://orcid.org/0000-0003-0792-5439","observed_orcids":["https://orcid.org/0000-0003-0792-5439"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Costa","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":4.1828,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.9497174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"286","issue":"1","first_page":"49","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nomifensine","display_name":"nomifensine","score":1.0},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7129999995231628},{"id":"https://openalex.org/keywords/motor-activity","display_name":"motor activity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dopamine-turnover","display_name":"dopamine turnover","score":0.8830000162124634},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7179999947547913},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.996999979019165},{"id":"https://openalex.org/keywords/norepinephrine-turnover","display_name":"norepinephrine turnover","score":0.843999981880188},{"id":"https://openalex.org/keywords/amphetamine","display_name":"amphetamine","score":0.7620000243186951},{"id":"https://openalex.org/keywords/apomorphine","display_name":"apomorphine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dopamine-reuptake-inhibition","display_name":"dopamine uptake inhibition","score":0.6100000143051147},{"id":"https://openalex.org/keywords/noradrenergic-neurons","display_name":"noradrenergic neurons","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.7160000205039978},{"id":"https://openalex.org/keywords/alpha-methyl-p-tyrosine","display_name":"alpha-methyl-p-tyrosine","score":0.7919999957084656},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2777078754","wikidata":"https://www.wikidata.org/wiki/Q409948","display_name":"Nomifensine","level":4,"score":0.9973786473274231},{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.8303097486495972},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7159947156906128},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6931402087211609},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6463361978530884},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.6355916261672974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6090657711029053},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5998944640159607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.559918999671936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44610726833343506},{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.4382498264312744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16563868522644043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15633466839790344}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000661","descriptor_name":"Amphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008781","descriptor_name":"Methyltyrosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00499104","doi":"https://doi.org/10.1007/bf00499104","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00499104","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:4375258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4375258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1663605807","https://openalex.org/W1775749144","https://openalex.org/W1968412872","https://openalex.org/W1968886334","https://openalex.org/W1977891604","https://openalex.org/W1980222581","https://openalex.org/W1984351646","https://openalex.org/W1987123703","https://openalex.org/W2000390463","https://openalex.org/W2009488498","https://openalex.org/W2014051479","https://openalex.org/W2016029553","https://openalex.org/W2018706976","https://openalex.org/W2025160443","https://openalex.org/W2029243562","https://openalex.org/W2052016700","https://openalex.org/W2053717798","https://openalex.org/W2063229129","https://openalex.org/W2076211169","https://openalex.org/W2088434836","https://openalex.org/W2091517145","https://openalex.org/W2092145492","https://openalex.org/W2094270485","https://openalex.org/W2148634234","https://openalex.org/W2157616701","https://openalex.org/W2253953550","https://openalex.org/W2415047446","https://openalex.org/W2417144413","https://openalex.org/W2417460653","https://openalex.org/W2606955141","https://openalex.org/W4249602146","https://openalex.org/W6602297405"],"related_works":["https://openalex.org/W2012307114","https://openalex.org/W2042963625","https://openalex.org/W2093804193","https://openalex.org/W2006071922","https://openalex.org/W2087611218","https://openalex.org/W1973946322","https://openalex.org/W2010209293","https://openalex.org/W2088434836","https://openalex.org/W2485607266","https://openalex.org/W2100396034"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}