{"id":"https://openalex.org/W2045112376","doi":"https://doi.org/10.1126/science.1335167","title":"Cloning of a Delta Opioid Receptor by Functional Expression","display_name":"Cloning of a Delta Opioid Receptor by Functional Expression","publication_year":1992,"publication_date":"1992-12-18","ids":{"openalex":"https://openalex.org/W2045112376","doi":"https://doi.org/10.1126/science.1335167","mag":"2045112376","pmid":"https://pubmed.ncbi.nlm.nih.gov/1335167"},"language":"en","primary_location":{"id":"doi:10.1126/science.1335167","doi":"https://doi.org/10.1126/science.1335167","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1335167","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079132033","display_name":"Christopher J. Evans","orcid":"https://orcid.org/0000-0003-0940-8224","observed_orcids":["https://orcid.org/0000-0003-0940-8224"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Evans","raw_affiliation_strings":["Department of Psychiatry, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90024-1759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90024-1759","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026109127","display_name":"Duane E. Keith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duane E. Keith","raw_affiliation_strings":["Department of Psychiatry, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90024-1759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90024-1759","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heather Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Morrison","raw_affiliation_strings":["Departments of Neurology and Microbiology and Immunology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90024-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Microbiology and Immunology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90024-1769","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113770371","display_name":"Karin Magendzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin Magendzo","raw_affiliation_strings":["Department of Psychiatry, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90024-1759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90024-1759","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027616900","display_name":"Robert H. Edwards","orcid":"https://orcid.org/0000-0002-8650-3260","observed_orcids":["https://orcid.org/0000-0002-8650-3260"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Edwards","raw_affiliation_strings":["Department of Neurology and the Molecular Biology Institute, University of California at Los Angeles School of Medicine, Los Angeles, CA 90024-1769"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Molecular Biology Institute, University of California at Los Angeles School of Medicine, Los Angeles, CA 90024-1769","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":30.5392,"has_fulltext":false,"cited_by_count":1220,"citation_normalized_percentile":{"value":0.99910186,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"258","issue":"5090","first_page":"1952","last_page":"1955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-cloning","display_name":"receptor cloning","score":0.8199999928474426},{"id":"https://openalex.org/keywords/functional-expression","display_name":"functional expression","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cos-cells","display_name":"COS cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/enkephalin-analogs","display_name":"enkephalin analogs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/opioid-peptides","display_name":"opioid peptides","score":0.5770000219345093},{"id":"https://openalex.org/keywords/somatostatin-receptors","display_name":"somatostatin receptors","score":0.7789999842643738},{"id":"https://openalex.org/keywords/angiotensin-receptors","display_name":"angiotensin receptors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-8-receptor","display_name":"interleukin-8 receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6860349178314209},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.610066294670105},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5639845132827759},{"id":"https://openalex.org/C141087196","wikidata":"https://www.wikidata.org/wiki/Q18030283","display_name":"\u03b4-opioid receptor","level":4,"score":0.4869590699672699},{"id":"https://openalex.org/C2777803847","wikidata":"https://www.wikidata.org/wiki/Q325101","display_name":"Enkephalin","level":4,"score":0.46460407972335815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4534209072589874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4151350259780884},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.4106452763080597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3037402927875519},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1724855601787567}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004174","descriptor_name":"Diprenorphine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004745","descriptor_name":"Enkephalins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005048","descriptor_name":"Etorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008961","descriptor_name":"Models, Structural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020881","descriptor_name":"Enkephalin, D-Penicillamine (2,5)-","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1335167","doi":"https://doi.org/10.1126/science.1335167","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1335167","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1335167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1335167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2853307429","display_name":"Center for Study of Opioid Receptors and Drugs of Abuse (CSORDA)","funder_award_id":"P50DA005010","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W217844696","https://openalex.org/W245031103","https://openalex.org/W1967446284","https://openalex.org/W1973120027","https://openalex.org/W1977472414","https://openalex.org/W1979385488","https://openalex.org/W1981839548","https://openalex.org/W1983585015","https://openalex.org/W1983915881","https://openalex.org/W1984414350","https://openalex.org/W1990311250","https://openalex.org/W1996940755","https://openalex.org/W1998517723","https://openalex.org/W2004798951","https://openalex.org/W2010051841","https://openalex.org/W2011645297","https://openalex.org/W2028023846","https://openalex.org/W2060999820","https://openalex.org/W2075811628","https://openalex.org/W2076523452","https://openalex.org/W2102420653","https://openalex.org/W2103791221","https://openalex.org/W2113808519","https://openalex.org/W2116949924","https://openalex.org/W2122569637","https://openalex.org/W2172323892","https://openalex.org/W2218443277","https://openalex.org/W2415422546","https://openalex.org/W2470116587"],"related_works":["https://openalex.org/W1988795579","https://openalex.org/W2039628680","https://openalex.org/W2012119611","https://openalex.org/W2492756347","https://openalex.org/W2088278912","https://openalex.org/W2026365975","https://openalex.org/W2150228932","https://openalex.org/W654187870","https://openalex.org/W1995744931","https://openalex.org/W2006209686"],"abstract_inverted_index":{"Opiate":[0],"drugs":[1,9],"have":[2,28],"potent":[3],"analgesic":[4],"and":[5,39,78],"addictive":[6],"properties.":[7],"These":[8],"interact":[10],"with":[11,41],"receptors":[12,25,74],"that":[13],"also":[14],"mediate":[15],"the":[16,24,46,73],"response":[17],"to":[18,67],"endogenous":[19],"opioid":[20,47,58],"peptide":[21,48],"ligands.":[22],"However,":[23],"for":[26,75],"opioids":[27],"eluded":[29],"definitive":[30],"molecular":[31],"characterization.":[32],"By":[33],"transient":[34],"expression":[35],"in":[36,71],"COS":[37],"cells":[38],"screening":[40],"an":[42],"iodinated":[43],"analog":[44],"of":[45],"enkephalin,":[49],"a":[50,55],"complementary":[51],"DNA":[52],"clone":[53],"encoding":[54],"functional":[56],"delta":[57],"receptor":[59],"has":[60],"been":[61],"identified.":[62],"The":[63],"sequence":[64],"shows":[65],"homology":[66],"G":[68],"protein-coupled":[69],"receptors,":[70],"particular":[72],"somatostatin,":[76],"angiotensin,":[77],"interleukin-8.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":34},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}