{"id":"https://openalex.org/W2045007459","doi":"https://doi.org/10.1016/s0960-894x(98)00634-9","title":"The use of neamine as a molecular template: Identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3\u2032-phosphotransferase type IIa by mass spectroscopy","display_name":"The use of neamine as a molecular template: Identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3\u2032-phosphotransferase type IIa by mass spectroscopy","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2045007459","doi":"https://doi.org/10.1016/s0960-894x(98)00634-9","mag":"2045007459","pmid":"https://pubmed.ncbi.nlm.nih.gov/9934458"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(98)00634-9","doi":"https://doi.org/10.1016/s0960-894x(98)00634-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(98)00634-9","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yi Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["Complex Carbohydrate Research Center, University of GA, Athens 30602-4712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Carbohydrate Research Center, University of GA, Athens 30602-4712, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088770342","display_name":"Juliatiek Roestamadji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliatiek Roestamadji","raw_affiliation_strings":["Departments of Chemistry, Wayne State University, Detroit, MI 48202, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry, Wayne State University, Detroit, MI 48202, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013812375","display_name":"Shahriar Mobashery","orcid":"https://orcid.org/0000-0002-7695-7883","observed_orcids":["https://orcid.org/0000-0002-7695-7883"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahriar Mobashery","raw_affiliation_strings":["Departments of Chemistry, Wayne State University, Detroit, MI 48202, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry, Wayne State University, Detroit, MI 48202, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072546813","display_name":"Ron Orlando","orcid":"https://orcid.org/0000-0002-4111-8326","observed_orcids":["https://orcid.org/0000-0002-4111-8326"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Orlando","raw_affiliation_strings":["Complex Carbohydrate Research Cente, University of GA, 220 Riverbend Road, Athens, GA 30602-4712, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Carbohydrate Research Cente, University of GA, 220 Riverbend Road, Athens, GA 30602-4712, U.S.A","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.4585,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55018808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"24","first_page":"3489","last_page":"3494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.21899999678134918,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neamine","display_name":"neamine","score":0.8379999995231628},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.9070000052452087},{"id":"https://openalex.org/keywords/active-site-residues","display_name":"active site residues","score":0.8600000143051147},{"id":"https://openalex.org/keywords/covalent-modification","display_name":"covalent modification","score":0.9020000100135803},{"id":"https://openalex.org/keywords/maldi-mass-spectrometry","display_name":"MALDI mass spectrometry","score":0.7839999794960022},{"id":"https://openalex.org/keywords/proteolytic-digestion","display_name":"proteolytic digestion","score":0.6200000047683716},{"id":"https://openalex.org/keywords/site-specific-modification","display_name":"site-specific modification","score":0.5130000114440918},{"id":"https://openalex.org/keywords/counterions","display_name":"counterions","score":0.4819999933242798},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8552127480506897},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.8352177143096924},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.683758556842804},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5583166480064392},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4677351415157318},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.44422027468681335},{"id":"https://openalex.org/C45656491","wikidata":"https://www.wikidata.org/wiki/Q1538418","display_name":"PEP group translocation","level":4,"score":0.4426642656326294},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42855125665664673},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.32151204347610474},{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009355","descriptor_name":"Neomycin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019868","descriptor_name":"Kanamycin Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(98)00634-9","doi":"https://doi.org/10.1016/s0960-894x(98)00634-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(98)00634-9","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:9934458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9934458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2897960003","display_name":null,"funder_award_id":"2P41-RR05351-06","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5662941156","display_name":"Resource for Integrated Glycotechnology","funder_award_id":"2p41rr005351-21","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7342883303","display_name":null,"funder_award_id":"AI 32245","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W43163001","https://openalex.org/W1561325021","https://openalex.org/W1960965614","https://openalex.org/W1973500454","https://openalex.org/W1976040246","https://openalex.org/W2050273457","https://openalex.org/W2066352920","https://openalex.org/W2072731386","https://openalex.org/W2290092661"],"related_works":["https://openalex.org/W2050273457","https://openalex.org/W12446465","https://openalex.org/W1976040246","https://openalex.org/W7062193249","https://openalex.org/W1984366927","https://openalex.org/W1498933837","https://openalex.org/W165956625","https://openalex.org/W1973500454","https://openalex.org/W2073435845","https://openalex.org/W2001830454"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
