{"id":"https://openalex.org/W2044966326","doi":"https://doi.org/10.1074/jbc.m204104200","title":"Importance of FADD Signaling in Serum Deprivation- and Hypoxia-induced Cardiomyocyte Apoptosis","display_name":"Importance of FADD Signaling in Serum Deprivation- and Hypoxia-induced Cardiomyocyte Apoptosis","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2044966326","doi":"https://doi.org/10.1074/jbc.m204104200","mag":"2044966326","pmid":"https://pubmed.ncbi.nlm.nih.gov/12063258"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m204104200","doi":"https://doi.org/10.1074/jbc.m204104200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m204104200","pdf_url":"http://www.jbc.org/article/S0021925820700141/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820700141/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018221928","display_name":"Wei Chao","orcid":"https://orcid.org/0000-0002-2505-1360","observed_orcids":["https://orcid.org/0000-0002-2505-1360"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chao","raw_affiliation_strings":["Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA","Department of Anesthesia and Critical Care, Harvard Medical School, Charlestown, Massachusetts 02129","From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068093752","display_name":"Yan Shen","orcid":"https://orcid.org/0000-0002-3204-7095","observed_orcids":["https://orcid.org/0000-0002-3204-7095"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Shen","raw_affiliation_strings":["Department of Anesthesia and Critical Care, Harvard Medical School, Charlestown, Massachusetts 02129","From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435330","display_name":"Ling Li","orcid":"https://orcid.org/0000-0002-1940-8693","observed_orcids":["https://orcid.org/0000-0002-1940-8693"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":["From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050240892","display_name":"Anthony Rosenzweig","orcid":"https://orcid.org/0000-0001-6387-0386","observed_orcids":["https://orcid.org/0000-0001-6387-0386"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony Rosenzweig","raw_affiliation_strings":["Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129","From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Harvard Medical School, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050240892"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2949,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.88445924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"277","issue":"35","first_page":"31639","last_page":"31645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.984000027179718},{"id":"https://openalex.org/keywords/death-receptor-signaling","display_name":"death receptor signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":1.0},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9829999804496765},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9850000143051147},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.6919999718666077},{"id":"https://openalex.org/keywords/ischemic-heart-disease","display_name":"ischemic heart disease","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neonatal-cardiomyocytes","display_name":"neonatal cardiomyocytes","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.8816521167755127},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6919596195220947},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6578171253204346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46075162291526794},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4397132992744446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35146498680114746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3393380641937256},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3352817893028259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3321020007133484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3079849183559418},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.14250624179840088},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.1251620054244995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1244594156742096},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.062244266271591187},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000590","descriptor_name":"Amino Acid Chloromethyl Ketones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m204104200","doi":"https://doi.org/10.1074/jbc.m204104200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m204104200","pdf_url":"http://www.jbc.org/article/S0021925820700141/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12063258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12063258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m204104200","doi":"https://doi.org/10.1074/jbc.m204104200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m204104200","pdf_url":"http://www.jbc.org/article/S0021925820700141/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1901615924","display_name":"ROLE OF IGF-I IN PREVENTING CARDIOMYOCYTE APOPTOSIS","funder_award_id":"K08HL004336","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6170885698","display_name":"Role of myostatin in cardiac hypertrophy and failure","funder_award_id":"R01HL061557","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7800912345","display_name":"Role of Integrin-Linked Kinase in Heart Failure and Ischemic Injury","funder_award_id":"R01HL059521","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320314185","display_name":"Society of Cardiovascular Anesthesiologists","ror":"https://ror.org/04nbx4a76"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044966326.pdf","grobid_xml":"https://content.openalex.org/works/W2044966326.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W197144613","https://openalex.org/W1593219141","https://openalex.org/W1970344859","https://openalex.org/W1976680355","https://openalex.org/W1986308149","https://openalex.org/W1995903946","https://openalex.org/W2012173926","https://openalex.org/W2012561199","https://openalex.org/W2015362281","https://openalex.org/W2025128734","https://openalex.org/W2029501678","https://openalex.org/W2034815057","https://openalex.org/W2041693042","https://openalex.org/W2061497413","https://openalex.org/W2062853648","https://openalex.org/W2073342372","https://openalex.org/W2099379562","https://openalex.org/W2113999599","https://openalex.org/W2120751716","https://openalex.org/W2133916339","https://openalex.org/W2146084342","https://openalex.org/W2147839367","https://openalex.org/W2151205576","https://openalex.org/W2153291580","https://openalex.org/W2156179144","https://openalex.org/W2157201513","https://openalex.org/W2157549025","https://openalex.org/W2162777657","https://openalex.org/W2164323243","https://openalex.org/W2256712532","https://openalex.org/W2315629023","https://openalex.org/W2341478304","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W2035296764","https://openalex.org/W4232624562","https://openalex.org/W2124131385","https://openalex.org/W2120751716","https://openalex.org/W2359912843","https://openalex.org/W2079935437","https://openalex.org/W2389892712","https://openalex.org/W2087041770","https://openalex.org/W2120994364","https://openalex.org/W2071224863"],"abstract_inverted_index":{"Although":[0],"cardiomyocyte":[1],"(CM)":[2],"apoptosis":[3,120,138,188],"has":[4],"been":[5,29],"well":[6,99,117,153],"described":[7],"in":[8,10,13,40,76,124,142,168],"both":[9,145],"vitro":[11],"and":[12,67,80,89,96,139,147,166,185],"vivo":[14],"models":[15,77],"of":[16,36,56,78,87,94,111,128,135,164,189],"ischemic":[17],"heart":[18],"disease,":[19],"the":[20,34,57,155,162],"intracellular":[21],"pathways":[22],"leading":[23],"to":[24,71,171,192],"CM":[25,41],"death":[26,37,58,64],"have":[27],"not":[28],"fully":[30],"characterized.":[31],"To":[32],"define":[33],"role":[35,178],"receptor":[38,59],"signaling":[39,181],"apoptosis,":[42],"we":[43],"constructed":[44],"recombinant":[45],"adenoviral":[46,133],"vectors":[47,70],"carrying":[48],"wild-type":[49],"(wt)":[50],"or":[51],"dominant":[52],"negative":[53],"(dn)":[54],"forms":[55],"adaptor":[60],"protein":[61],"FADD":[62],"(Fas-associated":[63],"domain":[65],"protein)":[66],"used":[68],"these":[69],"transduce":[72],"rat":[73],"neonatal":[74],"CMs":[75,143,169,190],"hypoxia-":[79],"serum":[81],"deprivation":[82],"(SD)-induced":[83],"apoptosis.":[84],"The":[85],"combination":[86],"SD":[88],"hypoxia":[90],"induced":[91],"rapid":[92],"activation":[93,115,163],"caspase-3":[95,140],"-8":[97],"as":[98,100,116,118,152,154],"DNA":[101],"fragmentation,":[102],"reaching":[103],"a":[104,176],"plateau":[105],"within":[106],"4-8":[107],"h.":[108],"Adenoviral":[109],"expression":[110,134],"FADD-dn":[112],"inhibited":[113,161],"caspase-8":[114,157],"hypoxia/SD-induced":[119],"at":[121],"24":[122],"h":[123],"an":[125],"moi":[126],"(multiplicity":[127],"infection)-dependent":[129],"manner.":[130],"In":[131],"contrast,":[132],"FADD-wt":[136],"increased":[137],"activity":[141],"under":[144],"normoxic":[146],"hypoxic":[148],"conditions.":[149],"Surprisingly,":[150],"FADD-dn,":[151],"specific":[156],"inhibitor":[158],"benzyloxycarbonyl-IETD-fluoromethylketone":[159],"also":[160],"caspase-9":[165],"-3":[167],"subjected":[170,191],"hypoxia/SD.":[172,193],"These":[173],"data":[174],"suggest":[175],"primary":[177],"for":[179,187],"FADD/caspase-8":[180],"that":[182],"is":[183],"necessary":[184],"sufficient":[186]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}