{"id":"https://openalex.org/W2044960283","doi":"https://doi.org/10.2174/157018007780867870","title":"Stereochemistry as a Determinant of the Anti-Leukemic Potency of Halopyridyl and Thiazolyl Thiourea Compounds","display_name":"Stereochemistry as a Determinant of the Anti-Leukemic Potency of Halopyridyl and Thiazolyl Thiourea Compounds","publication_year":2007,"publication_date":"2007-06-04","ids":{"openalex":"https://openalex.org/W2044960283","doi":"https://doi.org/10.2174/157018007780867870","mag":"2044960283"},"language":"en","primary_location":{"id":"doi:10.2174/157018007780867870","doi":"https://doi.org/10.2174/157018007780867870","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157018007780867870","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048956276","display_name":"Taracad K. Venkatachalam","orcid":"https://orcid.org/0000-0001-9747-1105","observed_orcids":["https://orcid.org/0000-0001-9747-1105"]},"institutions":[{"id":"https://openalex.org/I4210120419","display_name":"Paradigm Pharmaceuticals (United States)","ror":"https://ror.org/02krbtc48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taracad Venkatachalam","raw_affiliation_strings":["Paradigm Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paradigm Pharmaceuticals","institution_ids":["https://openalex.org/I4210120419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110121737","display_name":"Alexei O. Vassilev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110869","display_name":"Parker Hughes Cancer Center","ror":"https://ror.org/01ahys275","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexi Vassilev","raw_affiliation_strings":["Parker Hughes Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parker Hughes Institute","institution_ids":["https://openalex.org/I4210110869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080358651","display_name":"Alexi Benyunov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexi Benyunov","raw_affiliation_strings":["Pulmonary, Allergy, Critical Care and Sleep Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy, Critical Care and Sleep Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078427595","display_name":"Olga O. Grigoriants","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110869","display_name":"Parker Hughes Cancer Center","ror":"https://ror.org/01ahys275","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Grigoriants","raw_affiliation_strings":["Parker Hughes Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parker Hughes Institute","institution_ids":["https://openalex.org/I4210110869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080516881","display_name":"Heather E. Tibbles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110869","display_name":"Parker Hughes Cancer Center","ror":"https://ror.org/01ahys275","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Tibbles","raw_affiliation_strings":["Parker Hughes Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parker Hughes Institute","institution_ids":["https://openalex.org/I4210110869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091381226","display_name":"Fatih Mehmet Uckun","orcid":"https://orcid.org/0000-0001-9334-183X","observed_orcids":["https://orcid.org/0000-0001-9334-183X"]},"institutions":[{"id":"https://openalex.org/I4210110869","display_name":"Parker Hughes Cancer Center","ror":"https://ror.org/01ahys275","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110869"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatih Uckun","raw_affiliation_strings":["Parker Hughes Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parker Hughes Institute","institution_ids":["https://openalex.org/I4210110869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":null,"fwci":0.5128,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.60449582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"5","first_page":"318","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stereochemistry","display_name":"stereochemistry","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antileukemic-activity","display_name":"antileukemic activity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8379999995231628},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2780538656","wikidata":"https://www.wikidata.org/wiki/Q528995","display_name":"Thiourea","level":2,"score":0.9753550291061401},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8993334174156189},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.624701201915741},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5756343603134155},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45694124698638916},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.44469407200813293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2511189877986908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2050786018371582},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11453768610954285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.057640135288238525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/157018007780867870","doi":"https://doi.org/10.2174/157018007780867870","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157018007780867870","pdf_url":null,"source":{"id":"https://openalex.org/S106940122","display_name":"Letters in Drug Design & Discovery","issn_l":"1570-1808","issn":["1570-1808","1875-628X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Letters in Drug Design & Discovery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107610552","https://openalex.org/W2588892617","https://openalex.org/W2484668997","https://openalex.org/W2920973810","https://openalex.org/W2073720215","https://openalex.org/W1573188100","https://openalex.org/W2064126384","https://openalex.org/W2776951395","https://openalex.org/W2541818442","https://openalex.org/W3194231860"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}