{"id":"https://openalex.org/W2044936845","doi":"https://doi.org/10.1093/aje/kwi202","title":"Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease","display_name":"Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease","publication_year":2005,"publication_date":"2005-07-21","ids":{"openalex":"https://openalex.org/W2044936845","doi":"https://doi.org/10.1093/aje/kwi202","mag":"2044936845","pmid":"https://pubmed.ncbi.nlm.nih.gov/16033878"},"language":"en","primary_location":{"id":"doi:10.1093/aje/kwi202","doi":"https://doi.org/10.1093/aje/kwi202","is_oa":false,"landing_page_url":"https://doi.org/10.1093/aje/kwi202","pdf_url":null,"source":{"id":"https://openalex.org/S170967050","display_name":"American Journal of Epidemiology","issn_l":"0002-9262","issn":["0002-9262","1476-6256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Epidemiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1765/13871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111920393","display_name":"Donald J. Lehmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Donald J. Lehmann","raw_affiliation_strings":["The Oxford Project to Investigate Memory and Ageing (OPTIMA), Department of Pharmacology, University of Oxford, Oxford, United Kingdom. donald.lehmann@pharm.ox.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Oxford Project to Investigate Memory and Ageing (OPTIMA), Department of Pharmacology, University of Oxford, Oxford, United Kingdom. donald.lehmann@pharm.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090704136","display_name":"Mario Cortina\u2010Borja","orcid":"https://orcid.org/0000-0003-0627-2624","observed_orcids":["https://orcid.org/0000-0003-0627-2624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Cortina-Borja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108430034","display_name":"Donald R. Warden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald R. Warden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030330229","display_name":"A. David Smith","orcid":"https://orcid.org/0000-0002-1095-6722","observed_orcids":["https://orcid.org/0000-0002-1095-6722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. David Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015407411","display_name":"Kristel Sleegers","orcid":"https://orcid.org/0000-0002-0283-2332","observed_orcids":["https://orcid.org/0000-0002-0283-2332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristel Sleegers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004064960","display_name":"Jonathan A. Prince","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan A. Prince","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017009749","display_name":"Cornelia M. van Duijn","orcid":"https://orcid.org/0000-0002-2374-9204","observed_orcids":["https://orcid.org/0000-0002-2374-9204","https://orcid.org/0000-0001-8766-6224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cornelia M. van Duijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027119794","display_name":"Patrick G. Kehoe","orcid":"https://orcid.org/0000-0002-7542-1139","observed_orcids":["https://orcid.org/0000-0002-7542-1139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick G. Kehoe","raw_affiliation_strings":["Bristol Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Neuroscience","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111920393"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":4856,"currency":"USD","value_usd":4856},"apc_paid":null,"fwci":1.6274,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.84615385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"162","issue":"4","first_page":"305","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.1941000074148178,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ace-insertion-deletion-polymorphism","display_name":"ACE I/D polymorphism","score":0.9480000138282776},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.824999988079071},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9610000252723694},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5809999704360962},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8149999976158142},{"id":"https://openalex.org/keywords/heterosis","display_name":"heterosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.7559999823570251},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7044721245765686},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.662168025970459},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6183726787567139},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6061651706695557},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5436605215072632},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5054302215576172},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4945161044597626},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.49341335892677307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4821905195713043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38293731212615967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3292175531387329},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.3128350079059601},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12728753685951233}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006823","descriptor_name":"Hybrid Vigor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1093/aje/kwi202","doi":"https://doi.org/10.1093/aje/kwi202","is_oa":false,"landing_page_url":"https://doi.org/10.1093/aje/kwi202","pdf_url":null,"source":{"id":"https://openalex.org/S170967050","display_name":"American Journal of Epidemiology","issn_l":"0002-9262","issn":["0002-9262","1476-6256"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Epidemiology","raw_type":"journal-article"},{"id":"pmid:16033878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16033878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of epidemiology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/49b77d97-d78e-40d7-b1b7-dc566460f870","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/49b77d97-d78e-40d7-b1b7-dc566460f870","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lehmann, DJ, Cortina-Borja, M, Warden, DR, Smith, AD, Sleeglers, K, Prince, JA, Duijn, C & Kehoe, PG 2005, 'Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease', American Journal of Epidemiology, vol. 162, no. 4, pp. 305-317. https://doi.org/10.1093/aje/kwi202","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/86fdda33-c1f8-4120-a49e-49d4c6ec65ae","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/86fdda33-c1f8-4120-a49e-49d4c6ec65ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lehmann, D, Cortina-Borja, M, Warden, DR, Smith, AD, Sleegers, K, Prince, JA, van Duijn, CM & Kehoe, PG 2005, 'Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's Disease', American Journal of Epidemiology, vol. 162 (4), pp. 305 - 317. https://doi.org/10.1093/aje/kwi202","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/49b77d97-d78e-40d7-b1b7-dc566460f870","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/49b77d97-d78e-40d7-b1b7-dc566460f870","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Epidemiology, 162(4), 305 - 317. Oxford University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:13871","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/13871","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Epidemiology, 162(4), 305 - 317","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:120194","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/120194/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AM J EPIDEMIOL , 162 (4) 305 - 317. (2005)","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:47105","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/47105/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Epidemiology , 162 pp. 305-317. (2005)","raw_type":"Article"},{"id":"pmh:oai:repub.eur.nl:13871","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/13871","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Epidemiology vol. 162 no. 4, pp. 305-317","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2524081440","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/47105/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:repub.eur.nl:13871","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/13871","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Epidemiology, 162(4), 305 - 317","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W186268426","https://openalex.org/W1556008598","https://openalex.org/W1569630040","https://openalex.org/W1574183113","https://openalex.org/W1582334575","https://openalex.org/W1969761972","https://openalex.org/W1970419442","https://openalex.org/W1974711994","https://openalex.org/W1976824780","https://openalex.org/W1982200175","https://openalex.org/W1987144385","https://openalex.org/W1987923664","https://openalex.org/W1993237775","https://openalex.org/W1994834210","https://openalex.org/W1998251625","https://openalex.org/W2003334814","https://openalex.org/W2006436888","https://openalex.org/W2009613623","https://openalex.org/W2013521804","https://openalex.org/W2013688320","https://openalex.org/W2022477061","https://openalex.org/W2022635031","https://openalex.org/W2025180430","https://openalex.org/W2027140433","https://openalex.org/W2032070991","https://openalex.org/W2033439000","https://openalex.org/W2034331149","https://openalex.org/W2039379003","https://openalex.org/W2043088181","https://openalex.org/W2048552267","https://openalex.org/W2052321977","https://openalex.org/W2059510962","https://openalex.org/W2060926663","https://openalex.org/W2064502152","https://openalex.org/W2067432590","https://openalex.org/W2069761589","https://openalex.org/W2072303915","https://openalex.org/W2073179563","https://openalex.org/W2075794182","https://openalex.org/W2077108875","https://openalex.org/W2081040380","https://openalex.org/W2083117569","https://openalex.org/W2090411906","https://openalex.org/W2091939326","https://openalex.org/W2092925972","https://openalex.org/W2097532633","https://openalex.org/W2102952062","https://openalex.org/W2107328434","https://openalex.org/W2109921650","https://openalex.org/W2110301468","https://openalex.org/W2116321557","https://openalex.org/W2117913633","https://openalex.org/W2125470920","https://openalex.org/W2128253623","https://openalex.org/W2135849441","https://openalex.org/W2142231099","https://openalex.org/W2143109076","https://openalex.org/W2145488319","https://openalex.org/W2146211420","https://openalex.org/W2146729934","https://openalex.org/W2150000105","https://openalex.org/W2150669018","https://openalex.org/W2156220037","https://openalex.org/W2156653951","https://openalex.org/W2156696025","https://openalex.org/W2157823046","https://openalex.org/W2159988524","https://openalex.org/W2169252130","https://openalex.org/W2171405125","https://openalex.org/W2171586695","https://openalex.org/W2171812064","https://openalex.org/W2306066238","https://openalex.org/W2320350515","https://openalex.org/W2371224127","https://openalex.org/W3022868799","https://openalex.org/W3111762622","https://openalex.org/W4210821588","https://openalex.org/W4251900862"],"related_works":["https://openalex.org/W2159988524","https://openalex.org/W2080123209","https://openalex.org/W2003766652","https://openalex.org/W1976220692","https://openalex.org/W1997495457","https://openalex.org/W2145488319","https://openalex.org/W2315354639","https://openalex.org/W7095079288","https://openalex.org/W7008062349","https://openalex.org/W2524081440"],"abstract_inverted_index":{"Apolipoprotein":[0],"E":[1,76],"epsilon4":[2,77],"(APOE*4)":[3],"is":[4,20,164],"the":[5,16,21,28,74,124,148,151,171],"only":[6],"fully":[7],"established":[8],"susceptibility":[9],"allele":[10,78],"for":[11,30,192],"Alzheimer's":[12,43,54,89,110,157],"disease.":[13,44],"One":[14],"of":[15,27,53,73,88,150],"most":[17],"studied":[18],"candidates":[19],"insertion":[22],"(I)/deletion":[23],"(D)":[24],"polymorphism":[25],"(indel)":[26],"gene":[29],"angiotensin":[31,152],"I-converting":[32,153],"enzyme":[33,154],"(ACE).":[34],"This":[35,206],"study":[36],"aimed":[37],"to":[38,167,195],"clarify":[39],"its":[40],"association":[41,108,149,180],"with":[42,65,109,156,170,199],"The":[45],"meta-analysis":[46],"included":[47],"39":[48],"samples,":[49],"comprising":[50],"6,037":[51],"cases":[52],"disease":[55,90,158],"and":[56,70,133,181],"12,099":[57],"controls,":[58],"using":[59],"mainly":[60],"primary":[61],"data.":[62],"Potential":[63],"interactions":[64],"gender,":[66],"age,":[67],"ethnic":[68,126],"group,":[69],"carrier":[71],"status":[72],"apolipoprotein":[75],"were":[79,84,114,120,141],"all":[80,137],"examined.":[81],"D":[82,139],"homozygotes":[83,105,140],"at":[85,115,142],"reduced":[86,143],"risk":[87,173,191,204],"(odds":[91],"ratio":[92],"=":[93,102],"0.81,":[94],"95%":[95],"confidence":[96],"interval:":[97],"0.72,":[98],"0.90;":[99],"corrected":[100],"p":[101],"0.0004);":[103],"I":[104],"showed":[106],"no":[107],"disease,":[111],"while":[112],"heterozygotes":[113],"increased":[116,190],"risk.":[117,144],"Although":[118],"there":[119],"clear":[121],"differences":[122],"among":[123],"three":[125],"groups":[127,138],"examined":[128],"(North":[129],"Europeans,":[130,178],"South":[131],"Caucasians,":[132],"East":[134],"Asians),":[135],"in":[136,176],"These":[145],"results":[146],"confirm":[147],"indel":[155],"across":[159],"diverse":[160],"populations,":[161],"although":[162],"this":[163],"probably":[165],"due":[166,194],"linkage":[168],"disequilibrium":[169],"true":[172],"factor.":[174,205],"Further,":[175],"North":[177],"both":[179],"Hardy-Weinberg":[182],"analysis":[183],"suggested":[184],"partial":[185],"heterosis,":[186],"that":[187],"is,":[188],"an":[189],"heterozygotes,":[193],"a":[196],"hidden":[197],"interaction":[198,207],"another,":[200],"as":[201],"yet":[202],"unknown,":[203],"warrants":[208],"further":[209],"investigation.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}