{"id":"https://openalex.org/W2044933340","doi":"https://doi.org/10.1021/np8005716","title":"Isofuranonaphthoquinone Produced by an Actinoplanes Isolate","display_name":"Isofuranonaphthoquinone Produced by an Actinoplanes Isolate","publication_year":2009,"publication_date":"2009-05-18","ids":{"openalex":"https://openalex.org/W2044933340","doi":"https://doi.org/10.1021/np8005716","mag":"2044933340","pmid":"https://pubmed.ncbi.nlm.nih.gov/19449881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2861439"},"language":"en","primary_location":{"id":"doi:10.1021/np8005716","doi":"https://doi.org/10.1021/np8005716","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np8005716","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2861439","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085568508","display_name":"Qibo Zhang","orcid":"https://orcid.org/0000-0002-5714-5900","observed_orcids":["https://orcid.org/0000-0002-5714-5900","https://orcid.org/0000-0001-5648-6407"]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qibo Zhang","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031298298","display_name":"Aaron J. Peoples","orcid":"https://orcid.org/0009-0005-6944-6961","observed_orcids":["https://orcid.org/0009-0005-6944-6961"]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J. Peoples","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001709600","display_name":"Mithra T. Rothfeder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mithra T. Rothfeder","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036806536","display_name":"William P. Millett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William P. Millett","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011820938","display_name":"Brian C. Pescatore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Pescatore","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084134235","display_name":"Losee L. Ling","orcid":"https://orcid.org/0000-0002-5368-6777","observed_orcids":["https://orcid.org/0000-0002-5368-6777"]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Losee L. Ling","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013392201","display_name":"Charles M. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801820460","display_name":"NovoBiotic Pharmaceuticals","ror":"https://ror.org/03k45vj26","country_code":"US","type":"company","lineage":["https://openalex.org/I2801820460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles M. Moore","raw_affiliation_strings":["NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoBiotic Pharmaceuticals, 767C Concord Avenue, Cambridge, Massachusetts 02138","institution_ids":["https://openalex.org/I2801820460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013392201"],"corresponding_institution_ids":["https://openalex.org/I2801820460"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1989,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77380413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"72","issue":"6","first_page":"1213","last_page":"1215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinoplanes","display_name":"Actinoplanes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/actinomycetes","display_name":"actinomycetes","score":0.746999979019165},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/soil-microorganisms","display_name":"soil microbes","score":0.847000002861023},{"id":"https://openalex.org/keywords/iron-iii-complexation","display_name":"iron(III) complexation","score":0.902999997138977},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.5736149549484253},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5152304768562317},{"id":"https://openalex.org/C2778659115","wikidata":"https://www.wikidata.org/wiki/Q243992","display_name":"Furan","level":2,"score":0.47240227460861206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4427616596221924},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.4360049366950989},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.42960628867149353},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38349205255508423},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3638501763343811},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3327562212944031},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2341332733631134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000192","descriptor_name":"Actinomycetales","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012988","descriptor_name":"Soil Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/np8005716","doi":"https://doi.org/10.1021/np8005716","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np8005716","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:19449881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19449881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2861439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2861439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nat Prod","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2861439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2861439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nat Prod","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1005503150","display_name":"Isolating novel actinomycetes for antibiotic discovery","funder_award_id":"R43AI078572","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1952353341","display_name":"Developing Novel Antibiotics Against Yersinia pestis","funder_award_id":"R44AI063616","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8140407317","display_name":null,"funder_award_id":"1R43AI78572-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1546375258","https://openalex.org/W1995657012","https://openalex.org/W2001968022","https://openalex.org/W2004141398","https://openalex.org/W2010662206","https://openalex.org/W2013714495","https://openalex.org/W2015667619","https://openalex.org/W2017941693","https://openalex.org/W2024298926","https://openalex.org/W2036647435","https://openalex.org/W2041057624","https://openalex.org/W2086778544","https://openalex.org/W2091113559","https://openalex.org/W2101074361"],"related_works":["https://openalex.org/W3035179171","https://openalex.org/W2109708339","https://openalex.org/W2531541905","https://openalex.org/W2156958989","https://openalex.org/W205215111","https://openalex.org/W2353501858","https://openalex.org/W3152216653","https://openalex.org/W2068793617","https://openalex.org/W2059780837","https://openalex.org/W2051572294"],"abstract_inverted_index":{"A":[0],"new":[1],"isofuranonaphthoquinone,":[2],"7,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione,":[3],"was":[4,28,39],"isolated":[5],"from":[6],"cultures":[7],"of":[8,23,44],"an":[9,14],"Actinoplanes":[10],"isolate":[11],"obtained":[12],"using":[13],"in":[15],"situ":[16],"diffusion":[17],"technology":[18],"that":[19],"facilitates":[20],"the":[21,32,42],"isolation":[22],"soil":[24],"microorganisms.":[25],"This":[26],"compound":[27],"demonstrated":[29],"to":[30,34],"have":[31],"ability":[33],"complex":[35],"Fe(III).":[36],"The":[37],"structure":[38],"determined":[40],"on":[41],"basis":[43],"spectroscopic":[45],"data.":[46]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}