{"id":"https://openalex.org/W2044915453","doi":"https://doi.org/10.1371/journal.pone.0080926","title":"Human Serum Albumin and p53-Activating Peptide Fusion Protein Is Able to Promote Apoptosis and Deliver Fatty Acid-Modified Molecules","display_name":"Human Serum Albumin and p53-Activating Peptide Fusion Protein Is Able to Promote Apoptosis and Deliver Fatty Acid-Modified Molecules","publication_year":2013,"publication_date":"2013-11-21","ids":{"openalex":"https://openalex.org/W2044915453","doi":"https://doi.org/10.1371/journal.pone.0080926","mag":"2044915453","pmid":"https://pubmed.ncbi.nlm.nih.gov/24278348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3836765"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0080926","doi":"https://doi.org/10.1371/journal.pone.0080926","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0080926","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080926&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080926&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010943128","display_name":"Michelle R. Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle R. Joshi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066547423","display_name":"Nianhuan Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nianhuan Yao","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102961094","display_name":"Kenneth A. Myers","orcid":"https://orcid.org/0000-0003-4677-5146","observed_orcids":["https://orcid.org/0000-0003-4677-5146"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Myers","raw_affiliation_strings":["Department of Biological Sciences, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100390288","display_name":"Zhiyu Li","orcid":"https://orcid.org/0000-0001-5837-0547","observed_orcids":["https://orcid.org/0000-0001-5837-0547","https://orcid.org/0000-0003-0546-3023","https://orcid.org/0009-0002-9797-097X","https://orcid.org/0009-0008-3196-7739"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiyu Li","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I110357561"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100390288"],"corresponding_institution_ids":["https://openalex.org/I110357561"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.4477,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64136712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"11","first_page":"e80926","last_page":"e80926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06859999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/peptide-fusion-protein","display_name":"peptide fusion protein","score":0.5659999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/long-chain-fatty-acid-transport","display_name":"long-chain fatty acid transport","score":0.7059999704360962},{"id":"https://openalex.org/keywords/intracellular-delivery","display_name":"intracellular delivery","score":0.7289999723434448},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.5820000171661377},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.7540897130966187},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.6588568091392517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5941210389137268},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5915517807006836},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5244293808937073},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.4574512839317322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4315766990184784},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3911958336830139},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37230661511421204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34977519512176514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016650","descriptor_name":"Fluorescein-5-isothiocyanate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0080926","doi":"https://doi.org/10.1371/journal.pone.0080926","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0080926","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080926&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2823494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3836765","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3836765","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3836765","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24278348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24278348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.781.76","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.781.76","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/70/51/pone.0080926.PMC3836765.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a4405202374e4734b5feca4e88749850","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a4405202374e4734b5feca4e88749850","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 11, p e80926 (2013)","raw_type":"article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/257267","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/257267","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0080926","doi":"https://doi.org/10.1371/journal.pone.0080926","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0080926","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080926&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2563162408","display_name":"Regulation of Endothelial Cell Branching Morphogenesis via MCAK-targted Control","funder_award_id":"K22HL113069","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320318280","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044915453.pdf","grobid_xml":"https://content.openalex.org/works/W2044915453.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W165254100","https://openalex.org/W1481315855","https://openalex.org/W1546302387","https://openalex.org/W1573827588","https://openalex.org/W1579899042","https://openalex.org/W1591281137","https://openalex.org/W1767036196","https://openalex.org/W1976261939","https://openalex.org/W1985820931","https://openalex.org/W1989589242","https://openalex.org/W1989658721","https://openalex.org/W1989936068","https://openalex.org/W1999656510","https://openalex.org/W2003236156","https://openalex.org/W2011361940","https://openalex.org/W2017654147","https://openalex.org/W2038717222","https://openalex.org/W2046308571","https://openalex.org/W2052516738","https://openalex.org/W2058947924","https://openalex.org/W2065288525","https://openalex.org/W2065982479","https://openalex.org/W2076060796","https://openalex.org/W2077148563","https://openalex.org/W2078923880","https://openalex.org/W2084374650","https://openalex.org/W2092675732","https://openalex.org/W2093775600","https://openalex.org/W2097933346","https://openalex.org/W2103023541","https://openalex.org/W2103069797","https://openalex.org/W2107132365","https://openalex.org/W2108932391","https://openalex.org/W2127374913","https://openalex.org/W2130555878","https://openalex.org/W2131216411","https://openalex.org/W2133959309","https://openalex.org/W2144536924","https://openalex.org/W2153017356","https://openalex.org/W2153172903","https://openalex.org/W2154799239","https://openalex.org/W2169936771","https://openalex.org/W2394660565"],"related_works":["https://openalex.org/W3022073684","https://openalex.org/W3184617464","https://openalex.org/W7097686368","https://openalex.org/W3193606581","https://openalex.org/W3103787764","https://openalex.org/W2477105593","https://openalex.org/W4392816077","https://openalex.org/W4211241376","https://openalex.org/W2103020649","https://openalex.org/W2154559615"],"abstract_inverted_index":{"Therapeutic":[0],"peptides":[1,118],"offer":[2],"a":[3,22,39,48,57,86,101],"high":[4],"degree":[5],"of":[6,24,56,84,99,104,133,161,186,238],"specificity,":[7],"potency,":[8],"and":[9,31,125,136,151,154,213,215],"low":[10],"toxicity;":[11],"making":[12],"them":[13],"promising":[14],"candidates":[15],"for":[16],"cancer":[17],"therapy.":[18],"Despite":[19],"these":[20],"advantages,":[21],"number":[23],"hurdles,":[25],"such":[26,227],"as":[27,109,111,220],"poor":[28],"serum":[29,44,54,89],"stability":[30,55],"inefficient":[32],"cellular":[33],"penetration,":[34],"must":[35],"be":[36,73,210,232],"overcome.":[37],"Fusing":[38],"therapeutic":[40],"peptide":[41,58,102],"to":[42,51,61,75,94,120,130,234,248],"human":[43,88],"albumin":[45,90],"(HSA)":[46],"is":[47,181,224],"common":[49],"approach":[50,71,229],"extend":[52],"the":[53,82,122,131,159],"that":[59,69,140,192,226],"binds":[60],"extracellular":[62],"receptors.":[63],"However,":[64],"no":[65],"study":[66,189],"has":[67],"shown":[68],"this":[70],"can":[72,230],"applied":[74],"target":[76],"intracellular":[77,107,123,236],"proteins.":[78],"Here":[79],"we":[80],"demonstrate":[81],"feasibility":[83],"using":[85],"recombinant":[87],"(rHSA)":[91],"fusion":[92,142,164,194],"protein":[93],"simultaneously":[95],"deliver":[96],"two":[97,239],"types":[98],"molecules:":[100],"capable":[103],"binding":[105],"an":[106,182,228],"target,":[108],"well":[110],"fatty":[112,177],"acid":[113,178],"(FA)-modified":[114],"FITC":[115],"(FA-FITC).":[116],"Two":[117],"reported":[119],"disrupt":[121],"p53":[124],"MDM2/MDMX":[126],"interaction":[127],"were":[128,144],"fused":[129],"C-terminal":[132],"HSA.":[134,187],"Cellular":[135],"biochemical":[137],"studies":[138],"indicate":[139],"rHSA":[141,193],"proteins":[143,165,195],"efficiently":[145,212],"taken":[146],"up":[147],"by":[148],"SJSA-1":[149,170],"cells":[150,171],"retained":[152,217],"MDM2-":[153],"MDMX-binding":[155],"activity.":[156],"By":[157],"inducing":[158],"accumulation":[160],"p53,":[162],"both":[163],"promoted":[166],"efficient":[167],"cytotoxicity":[168],"in":[169],"via":[172,202],"caspase":[173],"activation.":[174],"Long":[175],"chain":[176],"(LCFA)":[179],"transportation":[180],"essential":[183],"endogenous":[184],"function":[185],"This":[188],"also":[190],"demonstrates":[191],"formed":[196],"highly":[197],"stable":[198],"complexes":[199],"with":[200,207,243],"FA-FITC":[201,205],"non-covalent":[203],"interactions.":[204],"complexed":[206],"HSA":[208],"could":[209],"internalized":[211],"rHSA-P53i":[214],"rHSA-PMI":[216],"apoptotic":[218],"activity":[219],"complex":[221],"components.":[222],"It":[223],"expected":[225],"ultimately":[231],"used":[233],"facilitate":[235],"delivery":[237],"anticancer":[240],"therapeutics,":[241],"each":[242],"distinct":[244],"but":[245],"complimentary":[246],"mechanisms,":[247],"achieve":[249],"synergistic":[250],"efficacy.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}