{"id":"https://openalex.org/W2044880496","doi":"https://doi.org/10.1074/jbc.m113.510248","title":"Mycothiol/Mycoredoxin 1-dependent Reduction of the Peroxiredoxin AhpE from Mycobacterium tuberculosis","display_name":"Mycothiol/Mycoredoxin 1-dependent Reduction of the Peroxiredoxin AhpE from Mycobacterium tuberculosis","publication_year":2013,"publication_date":"2013-12-31","ids":{"openalex":"https://openalex.org/W2044880496","doi":"https://doi.org/10.1074/jbc.m113.510248","mag":"2044880496","pmid":"https://pubmed.ncbi.nlm.nih.gov/24379404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3931079"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.510248","doi":"https://doi.org/10.1074/jbc.m113.510248","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.510248","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m113.510248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090618213","display_name":"Mart\u00edn Hugo","orcid":"https://orcid.org/0000-0003-3430-6457","observed_orcids":["https://orcid.org/0000-0003-3430-6457"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR","UY"],"is_corresponding":false,"raw_author_name":"Mart\u00edn Hugo","raw_affiliation_strings":["From the Departamento de Bioqu\u00edmica and","Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departamento de Bioqu\u00edmica and","institution_ids":["https://openalex.org/I4210149401"]},{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036470058","display_name":"Koen Van Laer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I4210140355","display_name":"VIB-VUB Center for Structural Biology","ror":"https://ror.org/03e84cm85","country_code":"BE","type":"facility","lineage":["https://openalex.org/I13469542","https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Van Laer","raw_affiliation_strings":["Brussels Center for Redox Biology, 1050 Brussels, Belgium","Structural Biology Brussels, Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium","Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), 1050 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brussels Center for Redox Biology, 1050 Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Structural Biology Brussels, Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084232092","display_name":"An\u00edbal M. Reyes","orcid":"https://orcid.org/0000-0003-3911-4649","observed_orcids":["https://orcid.org/0000-0003-3911-4649"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"An\u00edbal M. Reyes","raw_affiliation_strings":["Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040498940","display_name":"Didier Vertommen","orcid":"https://orcid.org/0000-0001-7648-8282","observed_orcids":["https://orcid.org/0000-0001-7648-8282"]},"institutions":[{"id":"https://openalex.org/I4210114657","display_name":"de Duve Institute","ror":"https://ror.org/022em3k58","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114657"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Didier Vertommen","raw_affiliation_strings":["de Duve Institute, Universit\u00e9 Catholique de Louvain, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"de Duve Institute, Universit\u00e9 Catholique de Louvain, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I4210114657","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076479367","display_name":"Joris Messens","orcid":"https://orcid.org/0000-0002-2128-8264","observed_orcids":["https://orcid.org/0000-0002-2128-8264"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I4210140355","display_name":"VIB-VUB Center for Structural Biology","ror":"https://ror.org/03e84cm85","country_code":"BE","type":"facility","lineage":["https://openalex.org/I13469542","https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Joris Messens","raw_affiliation_strings":["Brussels Center for Redox Biology, 1050 Brussels, Belgium","Structural Biology Brussels, Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium","Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), 1050 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brussels Center for Redox Biology, 1050 Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"Structural Biology Brussels, Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I4210140355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Rafael Radi","raw_affiliation_strings":["Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010572858","display_name":"Madia Trujillo","orcid":"https://orcid.org/0000-0003-2087-017X","observed_orcids":["https://orcid.org/0000-0003-2087-017X"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Madia Trujillo","raw_affiliation_strings":["Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5010572858","https://openalex.org/A5076479367"],"corresponding_institution_ids":["https://openalex.org/I13469542","https://openalex.org/I180910786","https://openalex.org/I2802017950","https://openalex.org/I4210140355"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6416,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.83112315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"289","issue":"8","first_page":"5228","last_page":"5239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/peroxiredoxin","display_name":"peroxiredoxin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mycothiol","display_name":"mycothiol","score":0.8690000176429749},{"id":"https://openalex.org/keywords/peroxide-detoxification","display_name":"peroxide detoxification","score":0.781000018119812},{"id":"https://openalex.org/keywords/mixed-disulfide-formation","display_name":"mixed disulfide formation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sulfenic-acid","display_name":"sulfenic acid","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6890000104904175},{"id":"https://openalex.org/keywords/nadph-oxidation","display_name":"NADPH oxidation","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7026466131210327},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.551472544670105},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5065995454788208},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.4786040484905243},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.4105566442012787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40965431928634644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3505091071128845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1971881091594696},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06683096289634705},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.04337778687477112},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054464","descriptor_name":"Peroxiredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1074/jbc.m113.510248","doi":"https://doi.org/10.1074/jbc.m113.510248","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.510248","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3299080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3931079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3931079","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3931079","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:24379404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24379404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:159754","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/159754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, Vol. 289, no. 8, p. 5228-5239 (2014)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:112273","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/mycothiolmycoredoxin-1dependent-reduction-of-the-peroxiredoxin-ahpe-from-mycobacterium-tuberculosis(8e448b93-f224-43f7-af46-eec26f4456c5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:84960","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/mycothiolmycoredoxin-1dependent-reduction-of-the-peroxiredoxin-ahpe-from-mycobacterium-tuberculosis(99c7b8dd-6782-46a2-886e-79036e3ecf62).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.510248","doi":"https://doi.org/10.1074/jbc.m113.510248","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.510248","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1543033526","https://openalex.org/W1549903994","https://openalex.org/W1576348820","https://openalex.org/W1702011451","https://openalex.org/W1924787971","https://openalex.org/W1963861745","https://openalex.org/W1964828026","https://openalex.org/W1965970801","https://openalex.org/W1975318934","https://openalex.org/W1979746007","https://openalex.org/W1979955102","https://openalex.org/W1981968407","https://openalex.org/W1983281028","https://openalex.org/W1989554592","https://openalex.org/W1994500027","https://openalex.org/W1996709333","https://openalex.org/W2001297244","https://openalex.org/W2002040395","https://openalex.org/W2006370393","https://openalex.org/W2007984621","https://openalex.org/W2009135248","https://openalex.org/W2012013653","https://openalex.org/W2012763468","https://openalex.org/W2022561948","https://openalex.org/W2023461354","https://openalex.org/W2035731751","https://openalex.org/W2046784759","https://openalex.org/W2056840435","https://openalex.org/W2066515050","https://openalex.org/W2070771964","https://openalex.org/W2073417483","https://openalex.org/W2073730042","https://openalex.org/W2075165294","https://openalex.org/W2080888441","https://openalex.org/W2088161908","https://openalex.org/W2090083421","https://openalex.org/W2090943533","https://openalex.org/W2098398789","https://openalex.org/W2104039316","https://openalex.org/W2113120391","https://openalex.org/W2120262061","https://openalex.org/W2122250625","https://openalex.org/W2124762109","https://openalex.org/W2162376892","https://openalex.org/W2166635130","https://openalex.org/W2489556331","https://openalex.org/W4250314341"],"related_works":["https://openalex.org/W2460669688","https://openalex.org/W2022561948","https://openalex.org/W2770586033","https://openalex.org/W91378313","https://openalex.org/W2613155865","https://openalex.org/W2001364394","https://openalex.org/W2012763468","https://openalex.org/W1924787971","https://openalex.org/W2075165294","https://openalex.org/W1965970801"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1,17,40],"(M.":[2],"tuberculosis),":[3],"the":[4,29,68,79,85,90,101,109,122,151,159,173,197,217,236,245],"pathogen":[5],"responsible":[6],"for":[7,59,224,229],"tuberculosis,":[8],"detoxifies":[9],"cytotoxic":[10],"peroxides":[11],"produced":[12],"by":[13,100,114,143,156,176,207],"activated":[14],"macrophages.":[15],"M.":[16,39],"expresses":[18],"alkyl":[19],"hydroxyperoxide":[20],"reductase":[21,51],"E":[22],"(AhpE),":[23],"among":[24],"other":[25],"peroxiredoxins.":[26],"So":[27],"far":[28],"system":[30,58],"that":[31],"reduces":[32,67],"AhpE":[33],"was":[34,191],"not":[35,118],"known.":[36],"We":[37,149,234],"identified":[38],"mycoredoxin-1":[41],"(MtMrx1)":[42],"acting":[43],"in":[44,104,139,158,178,231,248],"combination":[45],"with":[46,78,136,172,196],"mycothiol":[47,49,169,183,202],"and":[48,84,164,200,226,244],"disulfide":[50,77,96,135],"(MR),":[52],"as":[53],"a":[54,62,74,126,133,146,241],"biologically":[55],"relevant":[56],"reducing":[57],"MtAhpE.":[60,94],"MtMrx1,":[61],"glutaredoxin-like,":[63],"mycothiol-dependent":[64],"oxidoreductase,":[65],"directly":[66],"oxidized":[69,130],"form":[70],"of":[71,82,89,93,111,119,161,219],"MtAhpE,":[72],"through":[73],"protein":[75],"mixed":[76,134],"N-terminal":[80],"cysteine":[81,92,103],"MtMrx1":[83,113,120,144,177,208],"sulfenic":[86],"acid":[87],"derivative":[88],"peroxidatic":[91],"This":[95],"is":[97,141,184,203],"then":[98],"reduced":[99,142],"C-terminal":[102,123],"MtMrx1.":[105],"Accordingly,":[106],"MtAhpE":[107,131,157,190],"catalyzes":[108],"oxidation":[110,154],"wt":[112],"hydrogen":[115],"peroxide":[116,220],"but":[117],"lacking":[121],"cysteine,":[124],"confirming":[125],"dithiolic":[127],"mechanism.":[128,148],"Alternatively,":[129],"forms":[132],"mycothiol,":[137,225],"which":[138],"turn":[140],"using":[145],"monothiolic":[147],"demonstrated":[150],"H2O2-dependent":[152],"NADPH":[153],"catalyzed":[155],"presence":[160],"MR,":[162],"Mrx1,":[163],"mycothiol.":[165],"Disulfide":[166],"formation":[167],"involving":[168],"probably":[170],"competes":[171],"direct":[174,205],"reduction":[175,206],"aqueous":[179],"intracellular":[180],"media,":[181],"where":[182],"present":[185],"at":[186],"millimolar":[187],"concentrations.":[188],"However,":[189],"found":[192],"to":[193],"be":[194,210],"associated":[195],"membrane":[198],"fraction,":[199],"since":[201],"hydrophilic,":[204],"might":[209],"favored.":[211],"The":[212],"results":[213],"reported":[214],"herein":[215],"allow":[216],"rationalization":[218],"detoxification":[221],"actions":[222],"inferred":[223],"more":[227],"recently,":[228],"Mrx1":[230],"cellular":[232],"systems.":[233],"report":[235],"first":[237],"molecular":[238],"link":[239],"between":[240],"thiol-dependent":[242],"peroxidase":[243],"mycothiol/Mrx1":[246],"pathway":[247],"Mycobacteria.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}