{"id":"https://openalex.org/W2044865569","doi":"https://doi.org/10.1021/ja507168t","title":"A Potent \u03b1/\u03b2-Peptide Analogue of GLP-1 with Prolonged Action in Vivo","display_name":"A Potent \u03b1/\u03b2-Peptide Analogue of GLP-1 with Prolonged Action in Vivo","publication_year":2014,"publication_date":"2014-09-05","ids":{"openalex":"https://openalex.org/W2044865569","doi":"https://doi.org/10.1021/ja507168t","mag":"2044865569","pmid":"https://pubmed.ncbi.nlm.nih.gov/25191938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4183665"},"language":"en","primary_location":{"id":"doi:10.1021/ja507168t","doi":"https://doi.org/10.1021/ja507168t","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ja507168t","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/ja507168t?ref=article_openPDF","source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/ja507168t?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108201987","display_name":"Lisa M. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa M. Johnson","raw_affiliation_strings":["University of Wisconsin , , , ,","Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin , , , ,","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706,#R#United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058654037","display_name":"Stacey Barrick","orcid":"https://orcid.org/0000-0002-4837-3741","observed_orcids":["https://orcid.org/0000-0002-4837-3741"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Barrick","raw_affiliation_strings":["University of Pittsburgh School of Medicine , , , ,","Department#R#of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department#R#of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15620, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041085214","display_name":"Marlies V. Hager","orcid":"https://orcid.org/0000-0001-8050-4943","observed_orcids":["https://orcid.org/0000-0001-8050-4943"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marlies V. Hager","raw_affiliation_strings":["University of Wisconsin , , , ,","Department#R#of Chemistry, University of Wisconsin,#R#Madison, Wisconsin 53706,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin , , , ,","institution_ids":[]},{"raw_affiliation_string":"Department#R#of Chemistry, University of Wisconsin,#R#Madison, Wisconsin 53706,#R#United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049877102","display_name":"Amanda McFedries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda McFedries","raw_affiliation_strings":["Harvard University , , , ,","Department#R#of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University , , , ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department#R#of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018441218","display_name":"Edwin A. Homan","orcid":"https://orcid.org/0000-0002-2923-9635","observed_orcids":["https://orcid.org/0000-0002-2923-9635"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin A. Homan","raw_affiliation_strings":["Harvard University , , , ,","Department#R#of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University , , , ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department#R#of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112099109","display_name":"Mary E. Rabaglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. Rabaglia","raw_affiliation_strings":["University of Wisconsin , , , ,","Department#R#of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin , , , ,","institution_ids":[]},{"raw_affiliation_string":"Department#R#of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003503515","display_name":"Mark P. Keller","orcid":"https://orcid.org/0000-0002-7405-5552","observed_orcids":["https://orcid.org/0000-0002-7405-5552"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Keller","raw_affiliation_strings":["University of Wisconsin , , , ,","Department#R#of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin , , , ,","institution_ids":[]},{"raw_affiliation_string":"Department#R#of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066344931","display_name":"Alan Attie","orcid":"https://orcid.org/0000-0002-0568-2261","observed_orcids":["https://orcid.org/0000-0002-0568-2261"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan D. Attie","raw_affiliation_strings":["University of Wisconsin , , , ,","Department#R#of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin , , , ,","institution_ids":[]},{"raw_affiliation_string":"Department#R#of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065981856","display_name":"Alan Saghatelian","orcid":"https://orcid.org/0000-0002-0427-563X","observed_orcids":["https://orcid.org/0000-0002-0427-563X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Saghatelian","raw_affiliation_strings":["Harvard University , , , ,","Department#R#of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University , , , ,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department#R#of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013228845","display_name":"Alessandro Bisello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alessandro Bisello","raw_affiliation_strings":["University of Pittsburgh School of Medicine , , , ,","Department#R#of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine , , , ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department#R#of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15620, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023192029","display_name":"Samuel H. Gellman","orcid":"https://orcid.org/0000-0001-5617-0058","observed_orcids":["https://orcid.org/0000-0001-5617-0058"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel H. Gellman","raw_affiliation_strings":["University of Wisconsin , , , ,","Department#R#of Chemistry, University of Wisconsin,#R#Madison, Wisconsin 53706,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin , , , ,","institution_ids":[]},{"raw_affiliation_string":"Department#R#of Chemistry, University of Wisconsin,#R#Madison, Wisconsin 53706,#R#United States","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013228845","https://openalex.org/A5023192029","https://openalex.org/A5065981856","https://openalex.org/A5066344931"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I136199984","https://openalex.org/I170201317"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":6.4391,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.97595524,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"136","issue":"37","first_page":"12848","last_page":"12851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.195700004696846,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8659999966621399},{"id":"https://openalex.org/keywords/conformationally-constrained-peptides","display_name":"conformationally constrained peptides","score":0.6570000052452087},{"id":"https://openalex.org/keywords/peptide-stabilization","display_name":"peptide stabilization","score":0.5649999976158142},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.6940000057220459},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.922260582447052},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8413864374160767},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7093151807785034},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6468827128410339},{"id":"https://openalex.org/C185280430","wikidata":"https://www.wikidata.org/wiki/Q14909910","display_name":"Glucagon-like peptide 1 receptor","level":4,"score":0.5732409954071045},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.5687751173973083},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.566893994808197},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5330501794815063},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49849462509155273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4491061866283417},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35632702708244324},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.20090392231941223},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18121114373207092},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.15263047814369202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/ja507168t","doi":"https://doi.org/10.1021/ja507168t","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ja507168t","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/ja507168t?ref=article_openPDF","source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3537473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4183665","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4183665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4183665","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},{"id":"pmid:25191938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25191938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/22856917","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/ja507168t","doi":"https://doi.org/10.1021/ja507168t","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ja507168t","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/ja507168t?ref=article_openPDF","source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1832270909","display_name":"Novel Agonists and Inverse Agonists for B-Family GPCRs","funder_award_id":"R01GM056414","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3344537491","display_name":null,"funder_award_id":"ADA #7-12-IN-38","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G4638672853","display_name":"NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUES","funder_award_id":"R01DK056593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6934923361","display_name":"The Genetics of Obesity and Diabetes","funder_award_id":"R01DK058037","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G826341569","display_name":"Chemistry-Biology Interface Training Program","funder_award_id":"T32GM008505","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044865569.pdf","grobid_xml":"https://content.openalex.org/works/W2044865569.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W119240342","https://openalex.org/W1551855406","https://openalex.org/W1576285254","https://openalex.org/W1965819962","https://openalex.org/W1971495173","https://openalex.org/W1974086743","https://openalex.org/W1977881896","https://openalex.org/W1986326797","https://openalex.org/W1992074689","https://openalex.org/W1993072922","https://openalex.org/W1995513802","https://openalex.org/W1997831883","https://openalex.org/W2000050283","https://openalex.org/W2003706433","https://openalex.org/W2007141443","https://openalex.org/W2008845432","https://openalex.org/W2028645925","https://openalex.org/W2041492831","https://openalex.org/W2044639036","https://openalex.org/W2046652457","https://openalex.org/W2048553889","https://openalex.org/W2050486326","https://openalex.org/W2054731547","https://openalex.org/W2055885137","https://openalex.org/W2056283033","https://openalex.org/W2056594490","https://openalex.org/W2059105549","https://openalex.org/W2060789575","https://openalex.org/W2075824919","https://openalex.org/W2078171783","https://openalex.org/W2092139560","https://openalex.org/W2094251756","https://openalex.org/W2100049032","https://openalex.org/W2106824929","https://openalex.org/W2108693300","https://openalex.org/W2109014958","https://openalex.org/W2135743254","https://openalex.org/W2154382529","https://openalex.org/W2166430034","https://openalex.org/W2169503005","https://openalex.org/W2335029105","https://openalex.org/W4234803768","https://openalex.org/W4245650535","https://openalex.org/W4253101646"],"related_works":["https://openalex.org/W7096622586","https://openalex.org/W2948423169","https://openalex.org/W3018535542","https://openalex.org/W2059105549","https://openalex.org/W2259859286","https://openalex.org/W2496503361","https://openalex.org/W4307002300","https://openalex.org/W1986522335","https://openalex.org/W1966309593","https://openalex.org/W2151322171"],"abstract_inverted_index":{"Glucagon-like":[0],"peptide-1":[1],"(GLP-1)":[2],"is":[3,34],"a":[4,9,43],"natural":[5],"agonist":[6],"for":[7,25,46,76],"GLP-1R,":[8],"G":[10],"protein-coupled":[11],"receptor":[12],"(GPCR)":[13],"on":[14,57],"the":[15],"surface":[16],"of":[17,27,60,80],"pancreatic":[18],"\u03b2":[19],"cells.":[20],"GLP-1R":[21],"agoinsts":[22],"are":[23],"attractive":[24],"treatment":[26],"type":[28],"2":[29],"diabetes,":[30],"but":[31],"GLP-1":[32],"itself":[33],"rapidly":[35],"degraded":[36],"by":[37],"peptidases":[38],"in":[39,54],"vivo.":[40],"We":[41],"describe":[42],"design":[44],"strategy":[45],"retaining":[47],"GLP-1-like":[48],"activity":[49,53],"while":[50],"engendering":[51],"prolonged":[52],"vivo,":[55],"based":[56],"strategic":[58],"replacement":[59],"native":[61],"\u03b1":[62],"residues":[63],"with":[64],"conformationally":[65],"constrained":[66],"\u03b2-amino":[67],"acid":[68],"residues.":[69],"This":[70],"backbone-modification":[71],"approach":[72],"may":[73],"be":[74],"useful":[75],"developing":[77],"stabilized":[78],"analogues":[79],"other":[81],"peptide":[82],"hormones.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}