{"id":"https://openalex.org/W2044829324","doi":"https://doi.org/10.1620/tjem.221.69","title":"Fanconi Anemia Is Characterized by Delayed Repair Kinetics of DNA Double-Strand Breaks","display_name":"Fanconi Anemia Is Characterized by Delayed Repair Kinetics of DNA Double-Strand Breaks","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2044829324","doi":"https://doi.org/10.1620/tjem.221.69","mag":"2044829324","pmid":"https://pubmed.ncbi.nlm.nih.gov/20453460"},"language":"en","primary_location":{"id":"doi:10.1620/tjem.221.69","doi":"https://doi.org/10.1620/tjem.221.69","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.221.69","pdf_url":"https://www.jstage.jst.go.jp/article/tjem/221/1/221_1_69/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tjem/221/1/221_1_69/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084443829","display_name":"Andreja R. Leskovac","orcid":"https://orcid.org/0000-0002-6293-5237","observed_orcids":["https://orcid.org/0000-0002-6293-5237"]},"institutions":[{"id":"https://openalex.org/I4387152209","display_name":"Vin\u010da Institute of Nuclear Sciences","ror":"https://ror.org/04wecwh56","country_code":"RS","type":"facility","lineage":["https://openalex.org/I4068193","https://openalex.org/I4387152209"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Andreja Leskovac","raw_affiliation_strings":["Vinca Institute of Nuclear Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinca Institute of Nuclear Sciences","institution_ids":["https://openalex.org/I4387152209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071097753","display_name":"Dragana Vuji\u0107","orcid":"https://orcid.org/0000-0002-5708-4060","observed_orcids":["https://orcid.org/0000-0002-5708-4060"]},"institutions":[{"id":"https://openalex.org/I4210116938","display_name":"Institut za zdravstvenu za\u0161titu majke i deteta Srbije \"Dr Vukan \u010cupi\u0107\"","ror":"https://ror.org/02dx8kd29","country_code":"RS","type":"facility","lineage":["https://openalex.org/I4210116938"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Dragana Vujic","raw_affiliation_strings":["Mother and Child Health Care Institute of Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mother and Child Health Care Institute of Serbia","institution_ids":["https://openalex.org/I4210116938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031893431","display_name":"Marija Gu\u0107\u2010\u0160\u0107eki\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116938","display_name":"Institut za zdravstvenu za\u0161titu majke i deteta Srbije \"Dr Vukan \u010cupi\u0107\"","ror":"https://ror.org/02dx8kd29","country_code":"RS","type":"facility","lineage":["https://openalex.org/I4210116938"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Marija Guc-Scekic","raw_affiliation_strings":["Mother and Child Health Care Institute of Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mother and Child Health Care Institute of Serbia","institution_ids":["https://openalex.org/I4210116938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101892013","display_name":"Sandra \u017d. Petrovi\u0107","orcid":"https://orcid.org/0000-0003-0930-6455","observed_orcids":["https://orcid.org/0000-0003-0930-6455"]},"institutions":[{"id":"https://openalex.org/I4387152209","display_name":"Vin\u010da Institute of Nuclear Sciences","ror":"https://ror.org/04wecwh56","country_code":"RS","type":"facility","lineage":["https://openalex.org/I4068193","https://openalex.org/I4387152209"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Sandra Petrovic","raw_affiliation_strings":["Vinca Institute of Nuclear Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinca Institute of Nuclear Sciences","institution_ids":["https://openalex.org/I4387152209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078620465","display_name":"Ivana Joksi\u0107","orcid":"https://orcid.org/0000-0002-8890-0569","observed_orcids":["https://orcid.org/0000-0002-8890-0569"]},"institutions":[{"id":"https://openalex.org/I4387152209","display_name":"Vin\u010da Institute of Nuclear Sciences","ror":"https://ror.org/04wecwh56","country_code":"RS","type":"facility","lineage":["https://openalex.org/I4068193","https://openalex.org/I4387152209"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Ivana Joksic","raw_affiliation_strings":["Vinca Institute of Nuclear Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinca Institute of Nuclear Sciences","institution_ids":["https://openalex.org/I4387152209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030222127","display_name":"Predrag Slijep\u010devi\u0107","orcid":"https://orcid.org/0000-0003-0168-3598","observed_orcids":["https://orcid.org/0000-0003-0168-3598"]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Predrag Slijepcevic","raw_affiliation_strings":["Brunel Institute of Cancer Genetics & Pharmacogenomics, Brunel University","Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brunel Institute of Cancer Genetics & Pharmacogenomics, Brunel University","institution_ids":["https://openalex.org/I59433898"]},{"raw_affiliation_string":"Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012372823","display_name":"Gordana Joksi\u010b","orcid":"https://orcid.org/0000-0002-7186-301X","observed_orcids":["https://orcid.org/0000-0002-7186-301X"]},"institutions":[{"id":"https://openalex.org/I4387152209","display_name":"Vin\u010da Institute of Nuclear Sciences","ror":"https://ror.org/04wecwh56","country_code":"RS","type":"facility","lineage":["https://openalex.org/I4068193","https://openalex.org/I4387152209"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Gordana Joksic","raw_affiliation_strings":["Vinca Institute of Nuclear Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinca Institute of Nuclear Sciences","institution_ids":["https://openalex.org/I4387152209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8493,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67203498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"221","issue":"1","first_page":"69","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":1.0},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8949999809265137},{"id":"https://openalex.org/keywords/repair-kinetics","display_name":"repair kinetics","score":0.796999990940094},{"id":"https://openalex.org/keywords/gamma-h2ax-foci","display_name":"\u03b3H2AX foci","score":0.8980000019073486},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/radiation-induced-dna-damage","display_name":"radiation-induced DNA damage","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bone-marrow-failure-syndromes","display_name":"bone marrow failure syndromes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pancytopenia","display_name":"pancytopenia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.8248290419578552},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6009169816970825},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5660611391067505},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.545700192451477},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5259554386138916},{"id":"https://openalex.org/C2780525284","wikidata":"https://www.wikidata.org/wiki/Q7882181","display_name":"Bone marrow failure","level":4,"score":0.5071337223052979},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4915200173854828},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4866519570350647},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4051510691642761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39694175124168396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2767602205276489},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25430673360824585},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.1511940360069275},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.13714861869812012}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1620/tjem.221.69","doi":"https://doi.org/10.1620/tjem.221.69","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.221.69","pdf_url":"https://www.jstage.jst.go.jp/article/tjem/221/1/221_1_69/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:20453460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20453460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku journal of experimental medicine","raw_type":"Evaluation Study"},{"id":"pmh:oai:vinar.vin.bg.ac.rs:123456789/4000","doi":null,"is_oa":true,"landing_page_url":"https://vinar.vin.bg.ac.rs/handle/123456789/4000","pdf_url":null,"source":{"id":"https://openalex.org/S4306402108","display_name":"VinaR (Institute of Nuclear Sciences \"Vin\u010da\")","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210101313","host_organization_name":"University Hospital Center Dr Dragi\u0161a Mi\u0161ovi\u0107","host_organization_lineage":["https://openalex.org/I4210101313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tohoku Journal of Experimental Medicine","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1620/tjem.221.69","doi":"https://doi.org/10.1620/tjem.221.69","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.221.69","pdf_url":"https://www.jstage.jst.go.jp/article/tjem/221/1/221_1_69/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325356","display_name":"Julius-Maximilians-Universit\u00e4t W\u00fcrzburg","ror":"https://ror.org/00fbnyb24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044829324.pdf","grobid_xml":"https://content.openalex.org/works/W2044829324.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W110294243","https://openalex.org/W134444796","https://openalex.org/W1977273108","https://openalex.org/W1985775217","https://openalex.org/W2003379794","https://openalex.org/W2007932165","https://openalex.org/W2020779115","https://openalex.org/W2029491803","https://openalex.org/W2042119456","https://openalex.org/W2051193631","https://openalex.org/W2054689508","https://openalex.org/W2056332902","https://openalex.org/W2072397306","https://openalex.org/W2084969545","https://openalex.org/W2087505934","https://openalex.org/W2088374322","https://openalex.org/W2104213317","https://openalex.org/W2106845421","https://openalex.org/W2111003464","https://openalex.org/W2128680272","https://openalex.org/W2139884895","https://openalex.org/W2145806584","https://openalex.org/W2146176862","https://openalex.org/W2171183678","https://openalex.org/W4236684906"],"related_works":["https://openalex.org/W3091944553","https://openalex.org/W765598271","https://openalex.org/W2587764677","https://openalex.org/W2128457910","https://openalex.org/W1999998017","https://openalex.org/W244350917","https://openalex.org/W1977273108","https://openalex.org/W2137813245","https://openalex.org/W4243639201","https://openalex.org/W1990997564"],"abstract_inverted_index":{"Among":[0],"patients":[1,169],"with":[2,118],"bone":[3,184],"marrow":[4,185],"failure":[5,186],"(BMF)":[6],"syndrome,":[7],"some":[8],"are":[9],"happened":[10],"to":[11,31,45,53,63,130,141,182,216,240],"have":[12],"underlying":[13],"Fanconi":[14,77],"anemia":[15,78],"(FA),":[16],"a":[17,37,132,171],"genetically":[18],"heterogeneous":[19,32],"disease,":[20,36],"which":[21,99,236],"is":[22,50,90,112,195,205],"characterized":[23],"by":[24],"progressive":[25],"pancytopenia":[26],"and":[27,111,147,155,189,204],"cancer":[28],"susceptibility.":[29],"Due":[30],"nature":[33],"of":[34,59,69,88,92,105,134,152,177,201,211,225,232],"the":[35,93,108,150,162,175,229],"single":[38],"genetic":[39],"test,":[40],"as":[41,114,207],"in":[42,86,174,222],"vitro":[43],"response":[44],"DNA":[46,71,106,179],"cross-linking":[47],"agents,":[48],"usually":[49],"not":[51],"enough":[52],"make":[54],"correct":[55],"diagnosis.":[56],"The":[57,121,193,220],"aim":[58],"this":[60],"study":[61],"was":[62],"evaluate":[64],"whether":[65],"measuring":[66],"repair":[67,87,176,223],"kinetics":[68,224],"radiation-induced":[70,178],"double-strand":[72],"breaks":[73],"(DSBs)":[74],"can":[75],"distinguish":[76,241],"from":[79,107,125,167],"other":[80],"BMF":[81],"patients.":[82],"An":[83],"early":[84],"step":[85],"DSBs":[89,180],"phosphorylation":[91],"histone":[94],"H2AX,":[95],"generating":[96],"gamma-H2AX":[97,153,213],"histone,":[98],"extends":[100],"over":[101],"mega":[102],"base-pair":[103],"regions":[104],"break":[109],"site":[110],"visualised":[113],"foci":[115,154,214],"(gamma-H2AX":[116],"foci)":[117],"specific":[119],"antibodies.":[120],"primary":[122],"fibroblasts,":[123],"established":[124],"FA":[126,168,226,233,242],"patients,":[127],"were":[128],"exposed":[129],"gamma-rays,":[131],"dose":[133],"2":[135],"Gy":[136],"((60)Co),":[137],"incubated":[138],"for":[139,149],"up":[140],"24":[142,202],"hours":[143],"under":[144],"repair-permissive":[145],"conditions,":[146],"assayed":[148],"level":[151],"apoptosis":[156],"at":[157,198],"different":[158],"recovery":[159,199],"times":[160],"after":[161],"treatment.":[163],"Cell":[164],"lines":[165],"originating":[166],"displayed":[170],"significant":[172],"delay":[173,194,221],"relative":[181],"non-FA":[183],"(non-FA":[187],"BMF)":[188],"control":[190],"cell":[191],"lines.":[192],"especially":[196],"evident":[197],"time":[200],"hours,":[203],"seen":[206],"about":[208],"8-fold":[209],"increase":[210],"residual":[212],"compared":[215],"self-state":[217],"before":[218],"irradiation.":[219],"cells":[227],"represents":[228],"unique":[230],"feature":[231],"cellular":[234,243],"phenotype,":[235],"should":[237],"be":[238],"exploited":[239],"phenotype.":[244]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}