{"id":"https://openalex.org/W2044821990","doi":"https://doi.org/10.1016/j.expneurol.2005.09.014","title":"Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats","display_name":"Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats","publication_year":2005,"publication_date":"2005-11-03","ids":{"openalex":"https://openalex.org/W2044821990","doi":"https://doi.org/10.1016/j.expneurol.2005.09.014","mag":"2044821990","pmid":"https://pubmed.ncbi.nlm.nih.gov/16259981"},"language":"en","primary_location":{"id":"doi:10.1016/j.expneurol.2005.09.014","doi":"https://doi.org/10.1016/j.expneurol.2005.09.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2005.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022651094","display_name":"Courtney Robertson","orcid":"https://orcid.org/0000-0002-2561-3837","observed_orcids":["https://orcid.org/0000-0002-2561-3837"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Courtney L. Robertson","raw_affiliation_strings":["Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. croberts@peds.umaryland.edu","Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA","Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. croberts@peds.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075171296","display_name":"April Puskar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"April Puskar","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108619646","display_name":"Gloria E. Hoffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria E. Hoffman","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055828727","display_name":"Anne Z. Murphy","orcid":"https://orcid.org/0000-0003-2889-503X","observed_orcids":["https://orcid.org/0000-0003-2889-503X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Z. Murphy","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019892478","display_name":"Manda Saraswati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manda Saraswati","raw_affiliation_strings":["Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080399968","display_name":"Gary M. Fiskum","orcid":"https://orcid.org/0000-0001-5909-0539","observed_orcids":["https://orcid.org/0000-0001-5909-0539"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Fiskum","raw_affiliation_strings":["Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022651094"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":4.705,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.94959789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"197","issue":"1","first_page":"235","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.7409999966621399},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hippocampal-neuronal-loss","display_name":"hippocampal neuronal loss","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7749999761581421},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9359999895095825},{"id":"https://openalex.org/keywords/endogenous-hormone-levels","display_name":"endogenous hormone levels","score":0.6320000290870667},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/controlled-cortical-impact","display_name":"controlled cortical impact","score":0.7879999876022339},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8665629625320435},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8347591161727905},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7540020942687988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6466598510742188},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.6165160536766052},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5930967926979065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5472197532653809},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5239827036857605},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4196189343929291},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.expneurol.2005.09.014","doi":"https://doi.org/10.1016/j.expneurol.2005.09.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2005.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:16259981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16259981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2436154319","display_name":"Mitochondrial Dysfunction in Pediatric Head Injury","funder_award_id":"K08NS042805","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6509441857","display_name":null,"funder_award_id":"DAMD 17-99-1-9483","funder_id":"https://openalex.org/F4320337656","funder_display_name":"U.S. Army Medical Command"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337656","display_name":"U.S. Army Medical Command","ror":"https://ror.org/04vrzee53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W12904590","https://openalex.org/W1522782595","https://openalex.org/W1555821924","https://openalex.org/W1568752613","https://openalex.org/W1569823139","https://openalex.org/W1930502921","https://openalex.org/W1966060400","https://openalex.org/W1970991292","https://openalex.org/W1974948524","https://openalex.org/W1977373024","https://openalex.org/W1979013628","https://openalex.org/W1982210326","https://openalex.org/W1984259765","https://openalex.org/W1998277030","https://openalex.org/W2001828472","https://openalex.org/W2002947389","https://openalex.org/W2007922486","https://openalex.org/W2008225353","https://openalex.org/W2008772798","https://openalex.org/W2017716389","https://openalex.org/W2025923976","https://openalex.org/W2027261796","https://openalex.org/W2027513141","https://openalex.org/W2029559183","https://openalex.org/W2030158939","https://openalex.org/W2032306731","https://openalex.org/W2034775781","https://openalex.org/W2035277900","https://openalex.org/W2037486805","https://openalex.org/W2038776534","https://openalex.org/W2053943396","https://openalex.org/W2057290193","https://openalex.org/W2061629609","https://openalex.org/W2062754118","https://openalex.org/W2065110684","https://openalex.org/W2065518048","https://openalex.org/W2066505200","https://openalex.org/W2067629356","https://openalex.org/W2072627631","https://openalex.org/W2072668066","https://openalex.org/W2072837447","https://openalex.org/W2084054825","https://openalex.org/W2086070682","https://openalex.org/W2092065833","https://openalex.org/W2097920963","https://openalex.org/W2101309294","https://openalex.org/W2109850800","https://openalex.org/W2128590171","https://openalex.org/W2131092704","https://openalex.org/W2136742966","https://openalex.org/W2147849026","https://openalex.org/W2158239158","https://openalex.org/W2169867062","https://openalex.org/W2172099208","https://openalex.org/W2297037381"],"related_works":["https://openalex.org/W2021063378","https://openalex.org/W2057394458","https://openalex.org/W2098029347","https://openalex.org/W2322666502","https://openalex.org/W2100568017","https://openalex.org/W2383784189","https://openalex.org/W1977860019","https://openalex.org/W2389873886","https://openalex.org/W2031669289","https://openalex.org/W2021229480"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}