{"id":"https://openalex.org/W2044720719","doi":"https://doi.org/10.1159/000162969","title":"Ultrastructural Changes of Capillaries in Chronic Venous Insufficiency","display_name":"Ultrastructural Changes of Capillaries in Chronic Venous Insufficiency","publication_year":2008,"publication_date":"2008-10-07","ids":{"openalex":"https://openalex.org/W2044720719","doi":"https://doi.org/10.1159/000162969","mag":"2044720719"},"language":"en","primary_location":{"id":"doi:10.1159/000162969","doi":"https://doi.org/10.1159/000162969","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000162969","pdf_url":null,"source":{"id":"https://openalex.org/S4210187902","display_name":"Experimental Cell Biology","issn_l":"0304-3568","issn":["0304-3568","2235-1671"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059195884","display_name":"A Wenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. Wenner","raw_affiliation_strings":["Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112130351","display_name":"Hans J\u00f6rg Leu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H.J. Leu","raw_affiliation_strings":["Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Spycher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Spycher","raw_affiliation_strings":["Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112434774","display_name":"U Br\u00fcnner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"U. Brunner","raw_affiliation_strings":["Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and Department of Surgery B, University of Z\u00fcrich, Z\u00fcrich","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":null,"apc_paid":null,"fwci":1.8255,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.84715152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-venous-insufficiency","display_name":"chronic venous insufficiency","score":1.0},{"id":"https://openalex.org/keywords/capillary-ultrastructure","display_name":"capillary ultrastructure","score":0.9100000262260437},{"id":"https://openalex.org/keywords/venules","display_name":"venules","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pericapillary-space","display_name":"pericapillary space","score":0.7860000133514404},{"id":"https://openalex.org/keywords/erythrocyte-extravasation","display_name":"erythrocyte extravasation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/microvesicles","display_name":"microvesicles","score":0.9169999957084656},{"id":"https://openalex.org/keywords/transendothelial-channels","display_name":"transendothelial channels","score":0.9290000200271606},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/weibel-palade-bodies","display_name":"Weibel-Palade bodies","score":0.921999990940094},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.9779999852180481},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.8100137710571289},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.6840923428535461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5880341529846191},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5309184193611145},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47560033202171326},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4690782427787781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.440236359834671},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.43391916155815125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40217864513397217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3962404131889343},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3927748203277588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24140030145645142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08188050985336304},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07218411564826965},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1159/000162969","doi":"https://doi.org/10.1159/000162969","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000162969","pdf_url":null,"source":{"id":"https://openalex.org/S4210187902","display_name":"Experimental Cell Biology","issn_l":"0304-3568","issn":["0304-3568","2235-1671"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4246807413","https://openalex.org/W2070429653","https://openalex.org/W2064209539","https://openalex.org/W2494146205","https://openalex.org/W2462005752","https://openalex.org/W2410802569","https://openalex.org/W7098400440","https://openalex.org/W1988088911","https://openalex.org/W23780995","https://openalex.org/W2093133343"],"abstract_inverted_index":{"The":[0,20,52,124],"ultrastructural":[1],"changes":[2],"of":[3,13,26,31,37,99,117,121],"cutaneous":[4],"and":[5,8,28,36,79,95,102,120],"subcutaneous":[6],"capillaries":[7],"venules":[9],"in":[10,22,70,76,129,143],"6":[11],"cases":[12,24],"severe,":[14],"chronic":[15],"venous":[16],"insufficiency":[17],"were":[18],"examined.":[19],"findings":[21],"all":[23],"consisted":[25],"numerous":[27],"characteristic":[29],"alterations":[30],"the":[32,38,48,65,89,110,132,144],"vessel":[33],"wall":[34],"structure":[35],"pericapillary":[39],"space":[40],"which":[41,61],"are":[42,55,74,126,138],"supposed":[43],"to":[44,47,57,81,84,140],"be":[45,141],"due":[46],"increased":[49],"intravenous":[50],"pressure.":[51],"intercellular":[53],"spaces":[54],"enlarged":[56],"wide":[58],"channels":[59],"through":[60],"erythrocytes":[62,96],"pass":[63],"into":[64],"perivascular":[66],"spaces.":[67],"Microvesicles":[68],"occur":[69],"great":[71],"numbers,":[72],"they":[73],"arranged":[75],"chain-like":[77],"formations":[78],"seem":[80],"come":[82],"together":[83],"form":[85],"transendothelial":[86],"channels.":[87],"Around":[88],"capillaries,":[90],"edematous":[91],"fluid":[92],"with":[93,131],"proteins":[94],"accumulates.":[97],"Phagocytosis":[98],"erythrocytes,":[100],"siderosomes":[101],"collagen":[103],"fibrils":[104],"by":[105],"macrophages":[106],"is":[107,114],"observed.":[108],"Within":[109],"endothelial":[111],"cells":[112],"there":[113],"an":[115],"abundance":[116],"Weibel-Palade":[118,136],"bodies":[119,137],"multivesicular":[122],"bodies.":[123],"former":[125],"frequently":[127],"seen":[128],"contact":[130],"luminal":[133],"cell":[134],"membrane.":[135],"believed":[139],"involved":[142],"clotting":[145],"mechanism.":[146]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}