{"id":"https://openalex.org/W2044666334","doi":"https://doi.org/10.1093/brain/awu327","title":"Treatment-induced neuropathy of diabetes: an energy crisis?","display_name":"Treatment-induced neuropathy of diabetes: an energy crisis?","publication_year":2014,"publication_date":"2014-12-29","ids":{"openalex":"https://openalex.org/W2044666334","doi":"https://doi.org/10.1093/brain/awu327","mag":"2044666334","pmid":"https://pubmed.ncbi.nlm.nih.gov/25564488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4441082"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awu327","doi":"https://doi.org/10.1093/brain/awu327","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/awu327","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4441082","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047373167","display_name":"Phillip A. Low","orcid":"https://orcid.org/0000-0002-5386-4764","observed_orcids":["https://orcid.org/0000-0002-5386-4764"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip A. Low","raw_affiliation_strings":["Department of Neurology, Mayo Clinic College of Medicine, MN, USA low@mayo.edu","Department of Neurology, Mayo Clinic College of Medicine, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic College of Medicine, MN, USA low@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neurology, Mayo Clinic College of Medicine, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086023917","display_name":"Wolfgang Singer","orcid":"https://orcid.org/0000-0003-1263-6850","observed_orcids":["https://orcid.org/0000-0003-1263-6850"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Singer","raw_affiliation_strings":["Department of Neurology, Mayo Clinic College of Medicine, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic College of Medicine, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4224,"currency":"GBP","value_usd":5570},"apc_paid":null,"fwci":0.4303,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64665503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"138","issue":"1","first_page":"2","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.5849999785423279},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hba1c-reduction","display_name":"HbA1c reduction","score":0.9639999866485596},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.7609999775886536},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9509999752044678},{"id":"https://openalex.org/keywords/iatrogenic-complications","display_name":"iatrogenic complications","score":0.6990000009536743},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6119999885559082},{"id":"https://openalex.org/keywords/autonomic-failure","display_name":"autonomic failure","score":0.609000027179718},{"id":"https://openalex.org/keywords/mononeuropathy-multiplex","display_name":"mononeuropathy multiplex","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5894318222999573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5765589475631714},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.5294565558433533},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.413105309009552},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35982030630111694},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.32264626026153564},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20044225454330444}],"mesh":[{"descriptor_ui":"D001342","descriptor_name":"Autonomic Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/brain/awu327","doi":"https://doi.org/10.1093/brain/awu327","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/awu327","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3670674","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4441082","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4441082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4441082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"},{"id":"pmid:25564488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25564488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.665.1370","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.665.1370","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://brain.oxfordjournals.org/content/brain/138/1/2.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3670674","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4441082","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8259063287","display_name":"Differential Approach to the Postural Tachycardia Syndrome","funder_award_id":"K23NS075141","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1996586935","https://openalex.org/W2038233386","https://openalex.org/W2050145084","https://openalex.org/W2052749603","https://openalex.org/W2113384757","https://openalex.org/W2119767725","https://openalex.org/W2124788738","https://openalex.org/W2144944541","https://openalex.org/W2154974174","https://openalex.org/W2567133298","https://openalex.org/W4234962996","https://openalex.org/W6682959161"],"related_works":["https://openalex.org/W7095915654","https://openalex.org/W2154974174","https://openalex.org/W2472076990","https://openalex.org/W3013535722","https://openalex.org/W4320888559","https://openalex.org/W4283794328","https://openalex.org/W4214839939","https://openalex.org/W3171232673","https://openalex.org/W7113314160","https://openalex.org/W3163060274"],"abstract_inverted_index":{"This":[0,615,1159],"scientific":[1],"commentary":[2],"refers":[3],"to":[4,40,179,194,298,301,336,448,551,600,652,755,846,871,882,899,920,930,977,1063,1137,1151,1205,1265,1278,1282,1315,1328],"\u2018Treatment-induced":[5],"neuropathy":[6,55,102,144,184,753],"of":[7,13,30,33,53,91,128,138,145,151,158,175,198,247,252,261,276,295,308,319,362,379,400,411,419,424,464,488,524,555,567,587,613,645,701,707,728,744,751,764,951,966,980,984,994,1035,1083,1092,1129,1194,1199,1208,1218,1231,1289,1310,1319,1332],"diabetes:":[8],"an":[9,216,283,820,900,908,1039,1274],"acute,":[10],"iatrogenic":[11],"complication":[12],"diabetes\u2019":[14],"by":[15,98,108,215,436,580,658,889,969,1013,1154,1297],"Gibbons":[16,130,189,264],"and":[17,25,76,95,103,116,131,153,161,167,190,249,265,271,294,339,344,360,376,384,387,415,422,430,443,470,688,703,712,725,730,775,787,827,874,892,953,982,997,1007,1045,1071,1104,1119,1173],"Freeman":[18,132,191,266],"(10.1093/brain/awu307).":[19],"Peripheral":[20,746],"neuropathy,":[21,49,71],"together":[22],"with":[23,357,457,500,509,590,684,823,1026,1074,1089,1253,1271,1321,1325],"retinopathy":[24,466,1118,1172],"nephropathy,":[26],"constitute":[27],"a":[28,99,122,148,172,180,202,241,259,273,309,332,404,461,562,568,619,643,663,741,831,851,886,915,931,1019,1024,1049,1098,1166,1184,1210,1216,1298,1326],"triad":[29],"major":[31,333],"complications":[32],"chronic":[34,756,766,1076,1322],"hyperglycaemia":[35,758,767,782,1077,1324],"in":[36,125,204,219,236,312,317,331,413,557,571,584,622,629,666,734,748,768,792,800,803,810,903,907,934,1009,1023,1028,1087,1164,1249],"diabetes.":[37],"In":[38,121],"addition":[39],"the":[41,89,111,134,156,162,234,245,250,253,327,349,364,398,409,417,449,484,503,510,515,542,545,553,585,603,626,659,679,694,704,720,761,842,945,949,978,1004,1056,1085,1127,1147,1177,1232,1242,1267,1280,1287,1317,1330],"common":[42,742],"or":[43,222,225,347,936,963],"garden":[44],"predominantly":[45,709],"sensory":[46],"small":[47],"fibre":[48,947,981,1043],"many":[50,1032],"other":[51,388],"types":[52],"diabetic":[54,183,752],"have":[56,538,770,914,959,1245],"been":[57,539,960,1247],"described":[58,107],"(Dyck":[59,815,986],"et":[60,65,778,795,816,859,987,1015],"al.,":[61,66,779,796,817,860,988],"1993,":[62],"1999;":[63],"Tesfaye":[64],"2010).":[67],"These":[68,391],"include":[69],"autonomic":[70,104,223,288,385,425,713,731,954,998,1005,1105],"mononeuropathy,":[72],"mononeuropathy":[73],"multiplex,":[74],"radiculopathy,":[75],"radiculoplexus":[77],"neuropathy.":[78,525,1334],"Less":[79],"well":[80],"known":[81,141],"is":[82,96,113,454,483,491,505,625,637,642,662,674,813,941,975,1001,1055,1068,1097,1136,1160,1182,1295],"\u2018insulin":[83],"neuritis\u2019,":[84],"which":[85,913,1029,1107,1283],"develops":[86],"shortly":[87],"after":[88],"imposition":[90],"strict":[92,690],"glycaemic":[93,313,667,1224],"control":[94,314,1225],"characterized":[97,888],"length-dependent":[100],"painful":[101],"failure.":[105],"First":[106],"Caravati":[109],"(1933),":[110],"condition":[112,852],"considered":[114],"rare":[115],"its":[117,838],"mechanisms":[118],"are":[119,607,806,1065,1078],"unknown.":[120,957],"definitive":[123],"report":[124],"this":[126,139,1181],"issue":[127],"Brain,":[129],"provide":[133],"first":[135],"lucid":[136],"description":[137],"disorder\u2014now":[140],"as":[142,213,279,434,502,656,678,1048,1176,1204],"treatment-induced":[143,1333],"diabetes":[146,337,516,812,1238],"(TIND)\u2014in":[147],"large":[149,310,620,735],"group":[150],"subjects,":[152,363],"define":[154],"both":[155,416,733,995],"probability":[157],"developing":[159,290,465,1084],"TIND":[160,248,458,847,1067,1096],"main":[163],"risk":[164,246,463,528,612,1082,1331],"factors":[165],"(Gibbons":[166],"Freeman,":[168],"2014).":[169],"By":[170],"undertaking":[171],"retrospective":[173],"review":[174,365],"all":[176,268,507],"individuals":[177],"referred":[178,521],"tertiary":[181],"care":[182,338],"clinic":[185],"over":[186,291,323,1156,1257,1300],"5":[187],"years,":[188],"were":[192,329,392],"able":[193],"show":[195],"that":[196,455,618,648,673,853,973,992,1066,1072,1146,1165],">10%":[197],"patients":[199,508,1073,1320],"who":[200],"had":[201,460,544,848],"decrease":[203,316,412],"glycosylated":[205],"haemoglobin":[206],"A1C":[207],"(HbA1c)":[208],">2%":[209],"(104/954)":[210],"developed":[211],"TIND,":[212,277,489,630,677,1027],"defined":[214,278],"acute":[217],"increase":[218,281],"neuropathic":[220,420],"pain":[221,382,421,729,952,974,1008,1103],"symptoms":[224,228,386],"signs.":[226],"Such":[227,819],"occurred":[229],"far":[230],"less":[231],"frequently":[232],"when":[233,939],"reduction":[235,902,933,1196,1299],"HbA1c":[237,254,318,414,511,702,1290],"was":[238,366,403],"smaller,":[239],"suggesting":[240],"causal":[242],"relationship":[243],"between":[244,408],"size":[251,921],"reduction.":[255,1291],"The":[256,369,475,494,526,559,723,971,1011,1059,1133,1142,1308],"study":[257,476,487,1012,1179,1189,1211,1234],"has":[258,478,865],"number":[260],"particular":[262],"strengths.":[263],"evaluated":[267,345],"eligible":[269],"subjects":[270,300,456,843],"provided":[272],"uniform":[274],"diagnosis":[275],">3-point":[280],"on":[282,439,834,1018,1235],"11-point":[284],"Likert":[285],"scale,":[286],"and/or":[287],"dysfunction":[289,429],"2":[292],"weeks":[293,307],"sufficient":[296],"severity":[297,418],"cause":[299,784,855],"seek":[302],"medical":[303],"attention,":[304],"within":[305],"8":[306],"improvement":[311,665],"(a":[315],"\u22652":[320],"percentage":[321],"points":[322,1062],"3":[324,1157,1304],"months).":[325],"As":[326,862],"data":[328,560,1269,1272],"collected":[330],"centre":[334],"devoted":[335],"research":[340],"(Joslin":[341],"Diabetes":[342],"Centre)":[343],"there":[346,641],"at":[348,514,602,609,1079],"Beth":[350],"Israel":[351],"Deaconess":[352],"Medical":[353],"Centre":[354],"Neuropathy":[355],"Clinic,":[356],"systematized":[358],"evaluation":[359,523],"follow-up":[361],"unusually":[367,880],"thorough.":[368],"authors":[370,546,1143],"undertook":[371],"detailed":[372],"structured":[373],"neurological":[374],"examinations,":[375],"obtained":[377,1214],"logs":[378],"glucose":[380,573,624,647,935],"control,":[381,668],"scores,":[383],"microvascular":[389],"complications.":[390,1260],"measured":[393,435],"every":[394],"3\u20136":[395],"months":[396,1302],"for":[397,522,541,565,676,837,1003,1042,1051,1306],"duration":[399],"follow-up.":[401],"There":[402,958],"strong":[405,563],"statistical":[406],"correlation":[407],"magnitude":[410],"degree":[423],"failure":[426,955,1006],"(both":[427],"parasympathetic":[428],"sympathetic":[431],"adrenergic":[432],"function":[433],"orthostatic":[437],"hypotension":[438],"tilt":[440],"table":[441],"testing":[442],"beat-to-beat":[444],"blood":[445,572,623,646,773,801,825,867],"pressure":[446],"responses":[447],"Valsalva":[450],"manoeuvre).":[451],"Of":[452],"note":[453,1064],"also":[459,477,682,1116,1161],"higher":[462],"(P":[467,472],"<":[468,473],"0.001)":[469],"microalbuminuria":[471],"0.001).":[474],"certain":[479],"limitations.":[480],"Although":[481],"it":[482,490,661,877,1115],"largest":[485],"systematic":[486],"nevertheless":[492],"retrospective.":[493],"calculated":[495],"risks":[496],"should":[497,1149],"be":[498,601,650,879,927,1109,1124,1150,1198,1213,1263],"interpreted":[499],"caution":[501],"denominator":[504],"not":[506,598,638,1246],"drop":[512],"seen":[513],"centre,":[517],"but":[518,606],"only":[519],"those":[520],"presented":[527],"calculations":[529],"would":[530,537,616,829,878,926,990,1197,1313],"therefore":[531],"likely":[532,1206],"overestimate":[533],"absolute":[534],"risk.":[535],"It":[536,636,1261],"helpful":[540],"reader":[543],"used":[547],"their":[548,1093],"unique":[549],"dataset":[550],"address":[552],"role":[554,1041],"hypoglycaemia":[556,633,940],"TIND.":[558,588,654,970,1010],"make":[561],"case":[564],"involvement":[566,706,727],"rapid":[569,664,695],"fall":[570,621,696],"from":[574,697,1215,1273],"very":[575,581,698],"high":[576,582,699,1081],"levels":[577,700],"(as":[578],"reflected":[579],"A1c)":[583],"genesis":[586],"Subjects":[589],"lower":[591],"A1c":[592,1139,1153,1195],"(and":[593],"milder":[594],"average":[595],"hyperglycaemia)":[596],"do":[597],"seem":[599],"same":[604],"risk,":[605],"presumably":[608],"much":[610,916,1293],"greater":[611,917],"hypoglycaemia.":[614],"suggest":[617,991,1145],"critical":[627],"factor":[628],"rather":[631,669],"than":[632,670,923],"per":[634],"se.":[635],"clear":[639],"if":[640,897],"threshold":[644],"must":[649],"maintained":[651],"avoid":[653,1170],"Moreover,":[655,1095],"discussed":[657],"authors,":[660],"insulin":[671],"itself,":[672],"responsible":[675,1002],"syndrome":[680,1086],"can":[681,783,1123],"occur":[683],"oral":[685],"hypoglycaemic":[686],"agents":[687],"even":[689,938],"fasting.":[691],"Two":[692],"observations,":[693],"selective":[705],"small,":[708],"unmyelinated":[710,737,999],"somatic":[711,996],"C":[714],"fibres,":[715,732,739,912,925,1037],"raise":[716],"intriguing":[717],"questions":[718],"about":[719],"disease":[721],"pathogenesis.":[722],"abrupt":[724,901],"concomitant":[726],"part":[736],"\u2018C\u2019":[738],"evokes":[740],"mechanism":[743,1050],"injury.":[745],"nerves":[747,805,967],"animal":[749],"models":[750],"due":[754],"severe":[757,765,849,1075,1102,1323],"(which":[759],"model":[760],"current":[762,1178,1268],"situation":[763],"humans)":[769],"reduced":[771,824],"nerve":[772,808,864,1021,1036],"flow":[774,802,826,868],"oxygenation":[776],"(Tuck":[777,794,858],"1984).":[780,797,861],"Severe":[781],"endoneurial":[785,821,856,894,904],"oedema":[786,857,895],"increased":[788],"intercapillary":[789],"distance,":[790],"resulting":[791],"hypoxia":[793],"While":[798],"changes":[799],"rat":[804],"reversible,":[807],"ischaemia":[809,891],"human":[811],"irreversible":[814],"1986).":[818],"microenvironment,":[822],"hypoxia,":[828,890],"create":[830],"disproportionate":[832],"reliance":[833],"anaerobic":[835],"metabolism":[836],"energy":[839,909],"supply.":[840],"Notably,":[841],"most":[844,1060],"susceptible":[845,881,929,946],"hyperglycaemia,":[850],"could":[854],"peripheral":[863],"poor":[866],"autoregulation":[869],"compared":[870],"brain":[872],"(Low":[873],"Tuck,":[875],"1984),":[876],"milieu":[883],"changes.":[884],"Arguably,":[885],"microenvironment":[887],"perhaps":[893],"could,":[896],"subject":[898,1025],"glucose,":[905],"result":[906],"crisis.":[910],"Unmyelinated":[911],"surface":[918],"area":[919],"ratio":[922],"myelinated":[924],"unduly":[928],"sudden":[932],"ATP,":[937],"avoided.":[942],"Beyond":[943],"identifying":[944],"population,":[948],"mechanism(s)":[950],"remain":[956],"few":[961],"pathological":[962],"physiological":[964],"studies":[965,1312],"affected":[968],"conclusion":[972],"related":[976],"type":[979,1236,1250],"rate":[983,1288],"degeneration":[985,993],"1976)":[989],"fibres":[1000],"Llewelyn":[1014],"al.":[1016],"(1988)":[1017],"sural":[1020],"biopsy":[1022],"they":[1030],"found":[1031],"regenerating":[1033],"clusters":[1034],"suggests":[1038],"additional":[1040],"regeneration":[1044],"spontaneous":[1046],"firing":[1047],"painfulness.":[1052],"So":[1053],"what":[1054],"take-home":[1057],"message?":[1058],"important":[1061],"relatively":[1069],"common,":[1070],"particularly":[1080],"association":[1088],"vigorous":[1090],"treatment":[1091,1318],"hyperglycaemia.":[1094],"serious":[1099],"complication,":[1100],"causing":[1101],"failure,":[1106],"might":[1108,1169,1212,1262],"irreversible.":[1110],"Damage":[1111],"extends":[1112],"beyond":[1113],"nerves;":[1114],"worsens":[1117],"nephropathy.":[1120,1174],"What":[1121],"advice":[1122,1163],"gleaned":[1125],"regarding":[1126],"management":[1128],"severely":[1130],"hyperglycaemic":[1131],"subjects?":[1132],"obvious":[1134],"suggestion":[1135],"reduce":[1138,1152],"more":[1140],"gradually.":[1141],"sensibly":[1144],"goal":[1148],"<2%":[1155],"months.":[1158],"good":[1162],"graduated":[1167],"plan":[1168],"worsening":[1171,1258],"Important":[1175],"is,":[1180],"still":[1183],"discovery":[1185],"cohort.":[1186],"A":[1187],"prospective":[1188],"comparing":[1190],"two":[1191,1219],"different":[1192,1220],"rates":[1193],"great":[1200],"interest.":[1201],"Some":[1202],"clues":[1203],"outcomes":[1207,1284],"such":[1209,1311],"comparison":[1217],"time":[1221,1276],"periods.":[1222],"Tight":[1223],"gained":[1226],"significant":[1227],"momentum":[1228],"following":[1229],"publication":[1230],"DCCT":[1233],"I":[1237],"(Anonymous,":[1239],"1998);":[1240],"however,":[1241],"beneficial":[1243],"effects":[1244],"replicated":[1248],"II":[1251],"diabetes,":[1252],"concerns":[1254],"raised":[1255],"instead":[1256],"ischaemic":[1259],"interesting":[1264],"compare":[1266],"set":[1270],"earlier":[1275],"point":[1277],"assess":[1279],"extent":[1281],"depend":[1285],"upon":[1286],"How":[1292],"protection":[1294],"offered":[1296],"6":[1301],"versus":[1303],"months,":[1305],"example?":[1307],"results":[1309],"help":[1314],"inform":[1316],"view":[1327],"reducing":[1329]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
