{"id":"https://openalex.org/W2044638006","doi":"https://doi.org/10.1371/journal.pntd.0002839","title":"A Genome-Wide Analysis of Genetic Diversity in Trypanosoma cruzi Intergenic Regions","display_name":"A Genome-Wide Analysis of Genetic Diversity in Trypanosoma cruzi Intergenic Regions","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W2044638006","doi":"https://doi.org/10.1371/journal.pntd.0002839","mag":"2044638006","pmid":"https://pubmed.ncbi.nlm.nih.gov/24784238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4006747"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0002839","doi":"https://doi.org/10.1371/journal.pntd.0002839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002839","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002839&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002839&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077024273","display_name":"Leonardo G. Panunzi","orcid":"https://orcid.org/0000-0002-5770-7037","observed_orcids":["https://orcid.org/0000-0002-5770-7037"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210159438","display_name":"Instituto Tecnol\u00f3gico de Chascom\u00fas","ror":"https://ror.org/04qzr9r50","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I228664971","https://openalex.org/I4210123736","https://openalex.org/I4210159438","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Leonardo G. Panunzi","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas - Instituto Tecnol\u00f3gico de Chascom\u00fas, Universidad de San Mart\u00edn - CONICET, Sede San Mar\u00edtn, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas - Instituto Tecnol\u00f3gico de Chascom\u00fas, Universidad de San Mart\u00edn - CONICET, Sede San Mar\u00edtn, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210159438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077801542","display_name":"Fern\u00e1n Ag\u00fcero","orcid":"https://orcid.org/0000-0003-1331-5741","observed_orcids":["https://orcid.org/0000-0003-1331-5741"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210159438","display_name":"Instituto Tecnol\u00f3gico de Chascom\u00fas","ror":"https://ror.org/04qzr9r50","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I228664971","https://openalex.org/I4210123736","https://openalex.org/I4210159438","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Fern\u00e1n Ag\u00fcero","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas - Instituto Tecnol\u00f3gico de Chascom\u00fas, Universidad de San Mart\u00edn - CONICET, Sede San Mar\u00edtn, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas - Instituto Tecnol\u00f3gico de Chascom\u00fas, Universidad de San Mart\u00edn - CONICET, Sede San Mar\u00edtn, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210159438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077801542"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210159438"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":1.2584,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79669404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"5","first_page":"e2839","last_page":"e2839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":1.0},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.8450000286102295},{"id":"https://openalex.org/keywords/intergenic-regions","display_name":"intergenic regions","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/regulatory-elements","display_name":"regulatory elements","score":0.8690000176429749},{"id":"https://openalex.org/keywords/indels","display_name":"indels","score":0.5950000286102295},{"id":"https://openalex.org/keywords/sequence-motifs","display_name":"sequence motifs","score":0.7940000295639038},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"genome evolution","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C195139083","wikidata":"https://www.wikidata.org/wiki/Q3463539","display_name":"Intergenic region","level":4,"score":0.9348485469818115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7983506917953491},{"id":"https://openalex.org/C119054055","wikidata":"https://www.wikidata.org/wiki/Q1576681","display_name":"Indel","level":5,"score":0.7572688460350037},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7377052903175354},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.685823917388916},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.5032982230186462},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4995899200439453},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.493857204914093},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.4491802752017975},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.34436118602752686},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2012251913547516},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.16670706868171692},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.11078926920890808},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08372297883033752},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021901","descriptor_name":"DNA, Intergenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pntd.0002839","doi":"https://doi.org/10.1371/journal.pntd.0002839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002839","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002839&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2992399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4006747","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4006747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4006747","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmid:24784238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24784238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.815.7531","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.815.7531","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/44/67/pntd.0002839.PMC4006747.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:3837392","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3837392","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:c10f9a4b4f2242e69f69d8564116c3b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c10f9a4b4f2242e69f69d8564116c3b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2839 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1012973","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Genome_Wide_Analysis_of_Genetic_Diversity_in_Trypanosoma_cruzi_Intergenic_Regions/1012973","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/32321","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/32321","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"doi:10.60692/4eyk3-g6v57","doi":"https://doi.org/10.60692/4eyk3-g6v57","is_oa":true,"landing_page_url":"https://doi.org/10.60692/4eyk3-g6v57","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/pm6hr-zjv23","doi":"https://doi.org/10.60692/pm6hr-zjv23","is_oa":true,"landing_page_url":"https://doi.org/10.60692/pm6hr-zjv23","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0002839","doi":"https://doi.org/10.1371/journal.pntd.0002839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002839","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002839&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5207424189","display_name":"Parasitic Diseased Research at the IIB","funder_award_id":"D43TW007888","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G612586902","display_name":"Identificaci\u00f3n computacional y validaci\u00f3n experimental de blancos para desarrollo de drogas en Trypanosomas","funder_award_id":"PICT-2010-1479","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G7378882120","display_name":null,"funder_award_id":"CONICET","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044638006.pdf","grobid_xml":"https://content.openalex.org/works/W2044638006.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W157664703","https://openalex.org/W842237599","https://openalex.org/W1499500424","https://openalex.org/W1519266993","https://openalex.org/W1564217760","https://openalex.org/W1584129042","https://openalex.org/W1840360079","https://openalex.org/W1882986874","https://openalex.org/W1966171257","https://openalex.org/W1975518001","https://openalex.org/W1988014151","https://openalex.org/W1991857465","https://openalex.org/W1992379594","https://openalex.org/W1993624857","https://openalex.org/W1994296232","https://openalex.org/W1996065618","https://openalex.org/W1996518652","https://openalex.org/W2006717294","https://openalex.org/W2015252183","https://openalex.org/W2019922915","https://openalex.org/W2020152727","https://openalex.org/W2023663826","https://openalex.org/W2027023374","https://openalex.org/W2038605324","https://openalex.org/W2040083865","https://openalex.org/W2041383012","https://openalex.org/W2044388526","https://openalex.org/W2044924606","https://openalex.org/W2045346667","https://openalex.org/W2059823654","https://openalex.org/W2060245318","https://openalex.org/W2061246349","https://openalex.org/W2063524276","https://openalex.org/W2066194297","https://openalex.org/W2066198055","https://openalex.org/W2070309039","https://openalex.org/W2071501400","https://openalex.org/W2073424121","https://openalex.org/W2078447977","https://openalex.org/W2081148619","https://openalex.org/W2085434874","https://openalex.org/W2088156779","https://openalex.org/W2089306260","https://openalex.org/W2091306702","https://openalex.org/W2091360362","https://openalex.org/W2093413487","https://openalex.org/W2102034886","https://openalex.org/W2102606027","https://openalex.org/W2104349810","https://openalex.org/W2104891144","https://openalex.org/W2105219600","https://openalex.org/W2114091126","https://openalex.org/W2114803986","https://openalex.org/W2115219137","https://openalex.org/W2118767738","https://openalex.org/W2120194124","https://openalex.org/W2121991815","https://openalex.org/W2124769246","https://openalex.org/W2125310048","https://openalex.org/W2131887570","https://openalex.org/W2132926880","https://openalex.org/W2134124217","https://openalex.org/W2134314200","https://openalex.org/W2136145671","https://openalex.org/W2136711098","https://openalex.org/W2137360605","https://openalex.org/W2145772607","https://openalex.org/W2145958666","https://openalex.org/W2152219881","https://openalex.org/W2154109129","https://openalex.org/W2155011204","https://openalex.org/W2155159495","https://openalex.org/W2160265473","https://openalex.org/W2162649331","https://openalex.org/W2166706771","https://openalex.org/W2168967723","https://openalex.org/W2169307994","https://openalex.org/W2170045349","https://openalex.org/W2175504778","https://openalex.org/W2292320336","https://openalex.org/W2337638786","https://openalex.org/W2346486326","https://openalex.org/W2410102128","https://openalex.org/W2438190185","https://openalex.org/W4210980497","https://openalex.org/W4211252435","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7120351343","https://openalex.org/W2089306260","https://openalex.org/W2006717294","https://openalex.org/W2005676966","https://openalex.org/W2003262161","https://openalex.org/W4220680072","https://openalex.org/W2016342806","https://openalex.org/W2901792282","https://openalex.org/W4411076577","https://openalex.org/W1533017879"],"abstract_inverted_index":{"BACKGROUND:":[0],"Trypanosoma":[1],"cruzi":[2],"is":[3,39],"the":[4,11,24,45,67,76,107,122,137,210,217],"causal":[5],"agent":[6],"of":[7,13,26,44,51,57,121,136,139,156,178,191,201,207,212,219],"Chagas":[8],"Disease.":[9],"Recently,":[10],"genomes":[12,74],"representative":[14],"strains":[15],"from":[16,66],"two":[17,120],"major":[18],"evolutionary":[19,59,92],"lineages":[20],"were":[21,116],"sequenced,":[22],"allowing":[23],"construction":[25],"a":[27,48,90,154,189,199],"detailed":[28],"genetic":[29,127],"diversity":[30,128,175],"map":[31,38],"for":[32],"this":[33,37,148],"important":[34],"parasite.":[35],"However":[36],"focused":[40],"on":[41,147],"coding":[42,186],"regions":[43,53,87,114,131,171,215],"genome,":[46],"leaving":[47],"vast":[49],"space":[50],"regulatory":[52],"uncharacterized":[54],"in":[55,97,106,118,129,134,165,176],"terms":[56,135],"their":[58,181],"conservation":[60],"and/or":[61],"divergence.":[62],"METHODOLOGY:":[63],"Using":[64],"data":[65],"hybrid":[68],"CL":[69,99],"Brener":[70,100],"and":[71,78,94,103,105,141,184],"Sylvio":[72],"X10":[73],"(from":[75],"TcVI":[77],"TcI":[79,108],"Discrete":[80],"Typing":[81],"Units,":[82],"respectively),":[83],"we":[84,150],"identified":[85,152],"intergenic":[86,113,159,170,203,214],"that":[88,115,172,195],"share":[89],"common":[91],"ancestry,":[93],"are":[95,196],"present":[96],"both":[98],"haplotypes":[101],"(TcII-like":[102],"TcIII-like)":[104],"genome;":[109],"as":[110,112],"well":[111],"conserved":[117,158],"only":[119],"three":[123],"genomes/haplotypes":[124],"analyzed.":[125],"The":[126],"these":[130],"was":[132],"characterized":[133],"accumulation":[138],"indels":[140,208],"nucleotide":[142],"changes.":[143],"PRINCIPAL":[144],"FINDINGS:":[145],"Based":[146],"analysis":[149],"have":[151],"i)":[153],"core":[155],"highly":[157],"regions,":[160],"which":[161],"remained":[162],"essentially":[163],"unchanged":[164],"independently":[166],"evolving":[167],"lineages;":[168],"ii)":[169],"show":[173],"high":[174],"spite":[177],"still":[179],"retaining":[180],"corresponding":[182],"upstream":[183],"downstream":[185],"sequences;":[187],"iii)":[188],"number":[190,200],"defined":[192],"sequence":[193],"motifs":[194],"shared":[197],"by":[198,216],"unrelated":[202],"regions.":[204],"A":[205],"fraction":[206],"explains":[209],"diversification":[211],"some":[213],"expansion/contraction":[218],"microsatellite-like":[220],"repeats.":[221]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
