{"id":"https://openalex.org/W2044623920","doi":"https://doi.org/10.1007/s10637-014-0088-3","title":"Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer","display_name":"Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer","publication_year":2014,"publication_date":"2014-04-02","ids":{"openalex":"https://openalex.org/W2044623920","doi":"https://doi.org/10.1007/s10637-014-0088-3","mag":"2044623920","pmid":"https://pubmed.ncbi.nlm.nih.gov/24691674"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-014-0088-3","doi":"https://doi.org/10.1007/s10637-014-0088-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-014-0088-3","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028472820","display_name":"Johanna C. Bendell","orcid":"https://orcid.org/0000-0001-9426-5891","observed_orcids":["https://orcid.org/0000-0001-9426-5891"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johanna C. Bendell","raw_affiliation_strings":["Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Suite 110, 250 25th Avenue North, Nashville, TN, 37203, USA, jbendell@tnonc.com","Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Suite 110, 250 25th Avenue North, Nashville, TN, 37203, USA, jbendell@tnonc.com","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]},{"raw_affiliation_string":"Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, USA","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045441776","display_name":"Heinz\u2010Josef Lenz","orcid":"https://orcid.org/0000-0003-2178-9568","observed_orcids":["https://orcid.org/0000-0003-2178-9568"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heinz-Josef Lenz","raw_affiliation_strings":["Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","Norris Comprehensive Cancer Center - University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"Norris Comprehensive Cancer Center - University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103764612","display_name":"Theresa M. Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Ryan","raw_affiliation_strings":["Langone Medical Center, New York University, New York, NY, USA","Langone Medical Center New York University New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Langone Medical Center, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Langone Medical Center New York University New York USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057176768","display_name":"Bassel F. El\u2010Rayes","orcid":"https://orcid.org/0000-0002-2661-5746","observed_orcids":["https://orcid.org/0000-0002-2661-5746"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bassel F. El-Rayes","raw_affiliation_strings":["Winship Cancer Institute, Emory University, Atlanta, GA, USA","Winship Cancer Institute, Emory University, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061373605","display_name":"John Lindsay Marshall","orcid":"https://orcid.org/0000-0002-3449-2344","observed_orcids":["https://orcid.org/0000-0002-3449-2344"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Marshall","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA","Lombardi Comprehensive Cancer Center; Georgetown University; Washington USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center; Georgetown University; Washington USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111880602","display_name":"Manuel Modiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162453","display_name":"Arizona Oncology","ror":"https://ror.org/05c1xy536","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manuel R. Modiano","raw_affiliation_strings":["ACRC/Arizona Clinical Research Center and Arizona Oncology, Tucson, AZ, USA","ACRC/Arizona Clinical Research Center and Arizona Oncology, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRC/Arizona Clinical Research Center and Arizona Oncology, Tucson, AZ, USA","institution_ids":["https://openalex.org/I4210162453"]},{"raw_affiliation_string":"ACRC/Arizona Clinical Research Center and Arizona Oncology, Tucson, USA","institution_ids":["https://openalex.org/I4210162453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111656761","display_name":"Lowell L. Hart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lowell L. Hart","raw_affiliation_strings":["Florida Cancer Specialists/Sarah Cannon Research Institute, Fort Myers, FL, USA","Florida Cancer Specialists/Sarah Cannon Research Institute, Fort Myers, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Cancer Specialists/Sarah Cannon Research Institute, Fort Myers, FL, USA","institution_ids":["https://openalex.org/I4210100810"]},{"raw_affiliation_string":"Florida Cancer Specialists/Sarah Cannon Research Institute, Fort Myers, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030858806","display_name":"C. Daniel Kingsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118515","display_name":"Clearview Cancer Institute","ror":"https://ror.org/020cs7q41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clint D. Kingsley","raw_affiliation_strings":["Clearview Cancer Institute, Huntsville, AL, USA","Clearview Cancer Institute, Huntsville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clearview Cancer Institute, Huntsville, AL, USA","institution_ids":["https://openalex.org/I4210118515"]},{"raw_affiliation_string":"Clearview Cancer Institute, Huntsville, USA","institution_ids":["https://openalex.org/I4210118515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020154592","display_name":"Thomas J. George","orcid":"https://orcid.org/0000-0002-6249-9180","observed_orcids":["https://orcid.org/0000-0002-6249-9180"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. George","raw_affiliation_strings":["University of Florida, Gainesville, FL, USA","University of Florida, Gainesville USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053889199","display_name":"Daisuke Nakashima","orcid":"https://orcid.org/0000-0003-1105-2669","observed_orcids":["https://orcid.org/0000-0003-1105-2669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Nakashima","raw_affiliation_strings":["Kyowa Hakko Kirin Pharma, Inc., Princeton, NJ, USA","Kyowa Hakko Kirin Pharma Inc., Princeton, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyowa Hakko Kirin Pharma, Inc., Princeton, NJ, USA","institution_ids":[]},{"raw_affiliation_string":"Kyowa Hakko Kirin Pharma Inc., Princeton, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039492614","display_name":"Jordan D. Berlin","orcid":"https://orcid.org/0000-0001-7571-2385","observed_orcids":["https://orcid.org/0000-0001-7571-2385"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan D. Berlin","raw_affiliation_strings":["Vanderbilt-Ingram Cancer Center, Vanderbilt University, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232, USA","Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5028472820"],"corresponding_institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.6028,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.68371098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"4","first_page":"682","last_page":"690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9259999990463257},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7699999809265137},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.9546597599983215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9016408920288086},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7726080417633057},{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.7182449698448181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6906187534332275},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6535919308662415},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5426668524742126},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5214406847953796},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.4766322374343872},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46158650517463684},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45760679244995117},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3716825842857361},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35695022344589233},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32164767384529114},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.2941752076148987},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10637-014-0088-3","doi":"https://doi.org/10.1007/s10637-014-0088-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-014-0088-3","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:24691674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24691674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322359","display_name":"Kyowa Hakko Kirin","ror":"https://ror.org/0586k5242"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1500239805","https://openalex.org/W1554757194","https://openalex.org/W1905956901","https://openalex.org/W1967479446","https://openalex.org/W1968481237","https://openalex.org/W1988839148","https://openalex.org/W1992510232","https://openalex.org/W2011684762","https://openalex.org/W2029409133","https://openalex.org/W2033258778","https://openalex.org/W2061142243","https://openalex.org/W2107019084","https://openalex.org/W2115518353","https://openalex.org/W2128923437","https://openalex.org/W2130930654","https://openalex.org/W2137152330","https://openalex.org/W2139248078","https://openalex.org/W2156700619","https://openalex.org/W2160974436","https://openalex.org/W2162612721","https://openalex.org/W2166501356","https://openalex.org/W2166552565","https://openalex.org/W2254396289","https://openalex.org/W2266000670","https://openalex.org/W2275334344","https://openalex.org/W2414639108","https://openalex.org/W2431492348","https://openalex.org/W2589139005","https://openalex.org/W4239084925"],"related_works":["https://openalex.org/W2590742131","https://openalex.org/W2011684762","https://openalex.org/W2589139005","https://openalex.org/W3179889202","https://openalex.org/W2603152661","https://openalex.org/W2155889992","https://openalex.org/W7098783798","https://openalex.org/W3029364619","https://openalex.org/W2312316952","https://openalex.org/W2038033632"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}