{"id":"https://openalex.org/W2044595084","doi":"https://doi.org/10.1016/j.jalz.2010.08.184","title":"P4\u2010125: APP Antisense Reverses Learning and Memory Deficits in Two Mouse Strains of Alzheimer's","display_name":"P4\u2010125: APP Antisense Reverses Learning and Memory Deficits in Two Mouse Strains of Alzheimer's","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2044595084","doi":"https://doi.org/10.1016/j.jalz.2010.08.184","mag":"2044595084"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2010.08.184","doi":"https://doi.org/10.1016/j.jalz.2010.08.184","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.08.184","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2010.08.184","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2010.08.184","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037000230","display_name":"Susan A. Farr","orcid":"https://orcid.org/0000-0002-0481-2570","observed_orcids":["https://orcid.org/0000-0002-0481-2570"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan A. Farr","raw_affiliation_strings":["St. Louis University/VA, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Louis University/VA, St Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Banks","raw_affiliation_strings":["St. Louis University/VA, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Louis University/VA, St Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111459666","display_name":"Vijaya B. Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijaya B. Kumar","raw_affiliation_strings":["St. Louis University/VA, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Louis University/VA, St Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102748794","display_name":"John Edward Morley","orcid":"https://orcid.org/0000-0003-1104-0393","observed_orcids":["https://orcid.org/0000-0003-1104-0393"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Morley","raw_affiliation_strings":["St. Louis University/VA, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Louis University/VA, St Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":{"value":4200,"currency":"USD","value_usd":4200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17552921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4S_Part_21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6781119108200073},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5048981308937073},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4962983727455139},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48983022570610046},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.4417303800582886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4413875341415405},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.43639662861824036},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40454167127609253},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39006441831588745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3836045563220978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3664134740829468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3168221712112427},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.2659711539745331},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.22819748520851135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18294143676757812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18081626296043396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15771102905273438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2010.08.184","doi":"https://doi.org/10.1016/j.jalz.2010.08.184","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.08.184","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2010.08.184","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2010.08.184","doi":"https://doi.org/10.1016/j.jalz.2010.08.184","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2010.08.184","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2010.08.184","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044595084.pdf","grobid_xml":"https://content.openalex.org/works/W2044595084.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165798698","https://openalex.org/W1838526658","https://openalex.org/W7095776735","https://openalex.org/W2057346271","https://openalex.org/W1759837577","https://openalex.org/W2136097257","https://openalex.org/W2069603353","https://openalex.org/W1972445309","https://openalex.org/W1578812414","https://openalex.org/W2290270064"],"abstract_inverted_index":{"Alzheimer's":[0,22,134],"disease":[1,135],"(AD)":[2],"is":[3,73,106],"a":[4,32,60,114,150,218],"progressive":[5],"neurodegenerative":[6],"disorder":[7],"of":[8,21,41,82,85,96,112,133,184,224,239,349],"the":[9,19,48,94,164,168,191,206,225,228,232,240,243,262,283,288,306,318],"central":[10,140],"nervous":[11],"system":[12],"(CNS).":[13],"Learning":[14],"and":[15,53,70,100,119,128,139,172,179,186,317,340],"memory":[16,54,71,341],"deficits":[17],"are":[18,89],"hallmark":[20],"disease.":[23],"Studies":[24],"have":[25,173],"revealed":[26],"that":[27,63,72,105,166,216,309,334],"beta":[28],"amyloid":[29],"(A\u00df)":[30],"plays":[31],"key":[33],"role":[34],"in":[35,47,51,68,79,125,146,163,177,190,208,302,346],"these":[36,86],"deficits.":[37,55],"Elevated":[38],"brain":[39,49,80,95,182],"levels":[40,81,183],"A\u00df":[42,99],"lead":[43],"to":[44,98,198,257,297,327],"oxidative":[45,188],"damage":[46,189],"resulting":[50],"learning":[52,69,178,339],"The":[56,213,246,273,330],"SAMP8":[57,126,142,214],"mouse":[58],"has":[59],"natural":[61],"mutation":[62],"produces":[64],"an":[65,76,174,259],"age-related":[66,77,175],"impairment":[67,176,342],"driven":[74],"by":[75,91,344],"increase":[78],"A\u00df.":[83],"All":[84],"AD-like":[87],"characteristics":[88],"reversed":[90],"administration":[92],"into":[93],"antibody":[97],"antisense":[101,221,268,312,335],"oligonucleotide,":[102],"termed":[103],"mOL-1":[104,124,162,251,289],"directed":[107],"at":[108],"amino":[109],"acids":[110],"17-30":[111],"A\u00df1-42,":[113],"region":[115],"homologous":[116],"between":[117],"human":[118,169],"mouse.":[120],"Here,":[121],"we":[122],"tested":[123,145,160,205],"mice":[127,130,143,207,215,233,248,264,292,308],"Tg2576":[129,202,247,263,291,307],"two":[131],"models":[132],"using":[136],"both":[137,347],"peripheral":[138],"injections.":[141],"were":[144],"object":[147,230],"recognition":[148],"with":[149,250,266],"24":[151],"hour":[152],"delay":[153],"after":[154],"tail":[155],"vein":[156],"injection.":[157],"We":[158,193,204],"also":[159],"our":[161],"Tg2576,":[165],"overexpresses":[167],"APP":[170],"gene":[171],"memory,":[180],"elevated":[181],"A\u03b2,":[185],"increased":[187],"hippocampus.":[192],"administered":[194],"mOL-1,":[195],"intracerebroventricularly":[196],"(ICV)":[197],"13":[199],"month":[200],"old":[201],"mice.":[203,350],"T-maze":[209],"foot":[210],"shock":[211],"avoidance.":[212],"received":[217,235,310],"random":[219,267,311],"control":[220],"spent":[222,237],"39.67%":[223],"time":[226,241],"investigating":[227],"novel":[229,244],"whereas":[231,261],"which":[234],"OL-1":[236],"59.9%":[238],"exploring":[242],"object.":[245],"treated":[249,265,290],"took":[252,269,278,293,313,322],"9.00":[253,323],"\u00b1":[254,271,280,295,315,324],"0.72":[255],"trials":[256,326],"make":[258],"avoidance":[260],"14.50":[270],"1.73.":[272],"age-matched":[274],"wild":[275,319],"type":[276,320],"controls":[277,321],"10.09":[279],"0.66.":[281],"On":[282],"one":[284],"week":[285],"retention":[286],"test":[287],"8.73":[294],"0.63":[296],"reach":[298,328],"criterion":[299],"5":[300],"avoidances":[301],"6":[303],"consecutive":[304],"trials,":[305],"16.20":[314],"2.58":[316],"0.58":[325],"criterion.":[329],"current":[331],"findings":[332],"indicate":[333],"oligonucleotide":[336],"can":[337],"reverse":[338],"produced":[343],"A\u03b2":[345],"strains":[348]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}