{"id":"https://openalex.org/W2044575720","doi":"https://doi.org/10.1117/12.811768","title":"Association between lung function and airway wall density","display_name":"Association between lung function and airway wall density","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W2044575720","doi":"https://doi.org/10.1117/12.811768","mag":"2044575720"},"language":"en","primary_location":{"id":"doi:10.1117/12.811768","doi":"https://doi.org/10.1117/12.811768","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.811768","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065866225","display_name":"Joseph Ken Leader","orcid":"https://orcid.org/0000-0002-9612-6884","observed_orcids":["https://orcid.org/0000-0002-9612-6884"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Ken Leader","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045998635","display_name":"Bin Zheng","orcid":"https://orcid.org/0000-0002-7682-6648","observed_orcids":["https://orcid.org/0000-0002-7682-6648"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zheng","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111837602","display_name":"Carl R. Fuhrman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl R. Fuhrman","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027286465","display_name":"John R Tedrow","orcid":"https://orcid.org/0000-0002-4236-4430","observed_orcids":["https://orcid.org/0000-0002-4236-4430"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Tedrow","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112773899","display_name":"Sang C. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang C. Park","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100770593","display_name":"Jun Tan","orcid":"https://orcid.org/0000-0001-5827-4694","observed_orcids":["https://orcid.org/0000-0001-5827-4694","https://orcid.org/0000-0002-2281-5599"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Tan","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041650010","display_name":"Jiantao Pu","orcid":"https://orcid.org/0000-0003-2127-5313","observed_orcids":["https://orcid.org/0000-0003-2127-5313"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiantao Pu","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076410333","display_name":"John M. Drescher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Drescher","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076868240","display_name":"David Gur","orcid":"https://orcid.org/0000-0002-9067-2497","observed_orcids":["https://orcid.org/0000-0002-9067-2497"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gur","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042031961","display_name":"Frank C. Sciurba","orcid":"https://orcid.org/0000-0001-7468-2225","observed_orcids":["https://orcid.org/0000-0001-7468-2225"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank C. Sciurba","raw_affiliation_strings":["Univ. of Pittsburgh (United States)","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Pittsburgh (United States)","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":3.4465,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90223124,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"7262","issue":null,"first_page":"72622J","last_page":"72622J"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.9890000224113464},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"quantitative computed tomography","score":0.7480000257492065},{"id":"https://openalex.org/keywords/airway-morphometry","display_name":"airway morphometry","score":0.847000002861023},{"id":"https://openalex.org/keywords/airway-wall-area","display_name":"airway wall area","score":0.6589999794960022},{"id":"https://openalex.org/keywords/lung-density","display_name":"lung density","score":0.3779999911785126},{"id":"https://openalex.org/keywords/fev1-fvc-ratio","display_name":"FEV1/FVC ratio","score":0.8679999709129333},{"id":"https://openalex.org/keywords/copd-screening","display_name":"COPD screening","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.80608069896698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7218675017356873},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6294876933097839},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.5698227286338806},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.564186155796051},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5355901718139648},{"id":"https://openalex.org/C98503990","wikidata":"https://www.wikidata.org/wiki/Q28474","display_name":"Perimeter","level":2,"score":0.48455992341041565},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.4308469295501709},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.4240632653236389},{"id":"https://openalex.org/C2780314925","wikidata":"https://www.wikidata.org/wiki/Q181602","display_name":"Bronchus","level":4,"score":0.4146062731742859},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3751002550125122},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3323478698730469},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32286447286605835},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3057321310043335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3049222230911255},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.2793446183204651},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.20386549830436707},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1826479136943817},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14480850100517273}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.811768","doi":"https://doi.org/10.1117/12.811768","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.811768","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2382842200","https://openalex.org/W2114964437","https://openalex.org/W2382885148","https://openalex.org/W2007843141","https://openalex.org/W4233761918","https://openalex.org/W2385365614","https://openalex.org/W2048285687","https://openalex.org/W1974412059","https://openalex.org/W2043974404","https://openalex.org/W2152530209"],"abstract_inverted_index":{"Computed":[0],"tomography":[1],"(CT)":[2],"examination":[3],"is":[4,209],"often":[5],"used":[6],"to":[7,58,179,231],"quantify":[8],"the":[9,29,54,71,98,119,171,215],"relation":[10],"between":[11,31,134,167],"lung":[12,32,168,212],"function":[13,33,169],"and":[14,34,53,92,107,121,137,139,150,170,196],"airway":[15,35,84,100,172,180,193,206,226],"remodeling":[16],"in":[17,40,118,217,236],"chronic":[18],"obstructive":[19],"pulmonary":[20],"disease":[21],"(COPD).":[22],"In":[23],"this":[24],"preliminary":[25,202],"study,":[26,225],"we":[27],"examined":[28],"association":[30],"wall":[36,88,93,120,181,188,197,207,227],"computed":[37,113],"attenuation":[38],"(\"density\")":[39],"200":[41],"COPD":[42],"screening":[43],"subjects.":[44],"Percent":[45],"predicted":[46,50],"FVC":[47,59],"(FVC%),":[48],"percent":[49,199],"FEV1":[51,57],"(FEV1%),":[52],"ratio":[55],"of":[56,70,97,240],"as":[60,95],"a":[61,123,223],"percentage":[62],"(FEV1/FVC%)":[63],"were":[64,102,112,141,160,175,220],"measured":[65],"post-bronchodilator.":[66],"The":[67,129,156,165],"apical":[68],"bronchus":[69],"right":[72],"upper":[73],"lobe":[74],"was":[75,184],"manually":[76],"selected":[77],"from":[78],"CT":[79,238],"examinations":[80],"for":[81,158,163],"evaluation.":[82],"Total":[83],"area,":[85,87,89],"lumen":[86,90],"perimeter":[91],"area":[94,101,189,194,198],"fraction":[96],"total":[99],"computed.":[103],"Mean":[104],"HU":[105,109,124],"(meanHU)":[106],"maximum":[108],"(maxHU)":[110],"values":[111],"across":[114],"pixels":[115],"assigned":[116],"membership":[117],"with":[122,187,211],"value":[125],"greater":[126],"than":[127,222],"-550.":[128],"Pearson":[130],"correlation":[131],"coefficients":[132],"(PCC)":[133],"FVC%,":[135],"FEV1%,":[136],"FEV1/FVC%":[138],"meanHU":[140],"-0.221":[142],"(p":[143,147,152],"=":[144,148,153,191],"0.002),":[145],"-0.175":[146],"0.014),":[149],"-0.110":[151],"0.123),":[154],"respectively.":[155],"PCCs":[157],"maxHU":[159],"only":[161],"significant":[162],"FVC%.":[164],"correlations":[166,216],"morphometry":[173],"parameters":[174],"slightly":[176],"stronger":[177],"compared":[178],"density.":[182],"MeanHU":[183],"significantly":[185],"correlated":[186],"(PCC":[190],"0.720),":[192],"(0.498)":[195],"(0.611).":[200],"This":[201],"work":[203],"demonstrates":[204],"that":[205],"density":[208,228],"associated":[210],"function.":[213],"Although":[214],"our":[218],"study":[219],"weaker":[221],"recent":[224],"initially":[229],"appears":[230],"be":[232],"an":[233],"important":[234],"parameter":[235],"quantitative":[237],"analysis":[239],"COPD.":[241]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
