{"id":"https://openalex.org/W2044517409","doi":"https://doi.org/10.1177/0748730411411570","title":"Effects of the Duper Mutation on Circadian Responses to Light","display_name":"Effects of the Duper Mutation on Circadian Responses to Light","publication_year":2011,"publication_date":"2011-07-19","ids":{"openalex":"https://openalex.org/W2044517409","doi":"https://doi.org/10.1177/0748730411411570","mag":"2044517409","pmid":"https://pubmed.ncbi.nlm.nih.gov/21775288"},"language":"en","primary_location":{"id":"doi:10.1177/0748730411411570","doi":"https://doi.org/10.1177/0748730411411570","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748730411411570","pdf_url":null,"source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090181363","display_name":"Stefanie Krug","orcid":"https://orcid.org/0000-0001-6390-3184","observed_orcids":["https://orcid.org/0000-0001-6390-3184"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefanie Krug","raw_affiliation_strings":["Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA","Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111737253","display_name":"Judy McKinley Brewer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy McKinley Brewer","raw_affiliation_strings":["Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056756790","display_name":"Alexandre S. Bois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre S. Bois","raw_affiliation_strings":["Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023886055","display_name":"Eric L. Bittman","orcid":"https://orcid.org/0000-0001-6968-7590","observed_orcids":["https://orcid.org/0000-0001-6968-7590"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric L. Bittman","raw_affiliation_strings":["Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023886055"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.4427,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.60337727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"4","first_page":"293","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.6110000014305115},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tau-mutations","display_name":"tau mutations","score":0.6179999709129333},{"id":"https://openalex.org/keywords/phase-response-curve","display_name":"phase response curve","score":0.7080000042915344},{"id":"https://openalex.org/keywords/entrainment","display_name":"entrainment","score":0.8100000023841858},{"id":"https://openalex.org/keywords/free-running-period","display_name":"free-running period","score":0.7559999823570251},{"id":"https://openalex.org/keywords/per1","display_name":"Per1","score":0.5619999766349792},{"id":"https://openalex.org/keywords/period2","display_name":"Period2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dbp","display_name":"DBP","score":0.6620000004768372},{"id":"https://openalex.org/keywords/suprachiasmatic-nucleus","display_name":"suprachiasmatic nucleus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/recessive-alleles","display_name":"recessive alleles","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C139992725","wikidata":"https://www.wikidata.org/wiki/Q5380656","display_name":"Entrainment (biomusicology)","level":3,"score":0.8540772199630737},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7682304382324219},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5606067180633545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5596670508384705},{"id":"https://openalex.org/C63531555","wikidata":"https://www.wikidata.org/wiki/Q7180960","display_name":"Phase response curve","level":4,"score":0.5516541600227356},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5189963579177856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5034772753715515},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4878387749195099},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.4482552707195282},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.4189044237136841},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2759321331977844},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.22453859448432922},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.19774189591407776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15081098675727844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07852160930633545},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07478460669517517},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013493","descriptor_name":"Suprachiasmatic Nucleus","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/0748730411411570","doi":"https://doi.org/10.1177/0748730411411570","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748730411411570","pdf_url":null,"source":{"id":"https://openalex.org/S192515372","display_name":"Journal of Biological Rhythms","issn_l":"0748-7304","issn":["0748-7304","1552-4531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Rhythms","raw_type":"journal-article"},{"id":"pmid:21775288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21775288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological rhythms","raw_type":"Journal Article"},{"id":"pmh:oai:works.bepress.com:eric_bittman-1007","doi":null,"is_oa":false,"landing_page_url":"https://works.bepress.com/eric_bittman/4","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eric L. Bittman","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5330302665","display_name":"Suprachiasmatic Control of Peripheral Circadian Rhythms","funder_award_id":"R01MH070019","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332749","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1515558301","https://openalex.org/W1974667652","https://openalex.org/W1985474802","https://openalex.org/W1989025975","https://openalex.org/W2009415249","https://openalex.org/W2020244230","https://openalex.org/W2022123095","https://openalex.org/W2035809873","https://openalex.org/W2043209953","https://openalex.org/W2048129206","https://openalex.org/W2048466060","https://openalex.org/W2056846329","https://openalex.org/W2057438898","https://openalex.org/W2057522076","https://openalex.org/W2060242667","https://openalex.org/W2062228310","https://openalex.org/W2065041177","https://openalex.org/W2076593032","https://openalex.org/W2088678566","https://openalex.org/W2096819583","https://openalex.org/W2102639428","https://openalex.org/W2103758039","https://openalex.org/W2113336371","https://openalex.org/W2121075147","https://openalex.org/W2121771625","https://openalex.org/W2123064936","https://openalex.org/W2127447141","https://openalex.org/W2130179391","https://openalex.org/W2141765816","https://openalex.org/W2144479739","https://openalex.org/W2144598715","https://openalex.org/W2153890706","https://openalex.org/W2158252135","https://openalex.org/W2160091872","https://openalex.org/W2160510036","https://openalex.org/W2165208585","https://openalex.org/W2167165956","https://openalex.org/W3112761749","https://openalex.org/W3217417991","https://openalex.org/W4233811478","https://openalex.org/W4323238454"],"related_works":["https://openalex.org/W1981429775","https://openalex.org/W2094971018","https://openalex.org/W2513760033","https://openalex.org/W7065785552","https://openalex.org/W2896493576","https://openalex.org/W7098490200","https://openalex.org/W4291677156","https://openalex.org/W4225003385","https://openalex.org/W4391968292","https://openalex.org/W7168508122"],"abstract_inverted_index":{"The":[0],"circadian":[1,10,321],"mutation":[2,39,170,315],"duper":[3,51,62,65,117,129,134,187,218,220,242,275,304,314],"in":[4,101,151,158,240,250,258,262,267,299],"Syrian":[5],"hamsters":[6,52,63,96,118,132,221,278],"shortens":[7],"the":[8,35,128,166,169,205,229,235,238,244,251,268,300,313,317,320,328],"free-running":[9,203],"period":[11],"(\u03c4(DD))":[12],"by":[13,25,253],"2":[14],"hours":[15],"when":[16],"expressed":[17],"on":[18,28,40,66,135,171],"a":[19,29,57,67,136,211],"tau":[20,329],"mutant":[21,206],"(\u03c4(ss))":[22],"background":[23,138],"and":[24,44,94,149,219,276,295,323],"1":[26],"hour":[27],"wild-type":[30,93,137,263,277,307],"background.":[31],"We":[32],"have":[33],"examined":[34],"effects":[36],"of":[37,87,168,178,202,232,237,246,302,319],"this":[38,197],"phase":[41,59,142,224],"response":[42,102,159],"curves":[43],"entrainment.":[45],"In":[46,114,210],"contrast":[47],"to":[48,54,79,103,112,127,160,180,280,306],"wild":[49],"types,":[50],"entrained":[53],"14L:10D":[55],"with":[56,85],"positive":[58],"angle.":[60],"Super":[61],"(expressing":[64],"\u03c4(ss)":[68,74,95],"background)":[69],"showed":[70,82,154,291],"weak":[71],"entrainment,":[72],"while":[73],"animals":[75],"either":[76],"completely":[77],"failed":[78],"entrain":[80],"or":[81],"sporadic":[83],"entrainment":[84,179],"episodes":[86],"relative":[88],"coordination.":[89],"As":[90],"previously":[91],"reported,":[92],"show":[97,119,140,190,222],"low":[98],"amplitude":[99,121,156,173,318],"resetting":[100,157,192],"15-minute":[104,161],"light":[105,162,254,281,297],"pulses":[106],"after":[107],"short-term":[108],"(10":[109],"days)":[110],"exposure":[111],"DD.":[113,233],"contrast,":[115],"super":[116,217,241,274,303],"high":[120,155],"resetting.":[122],"This":[123],"effect":[124,167],"is":[125,174,208,255],"attributable":[126],"allele,":[130],"as":[131,199,226,228],"carrying":[133],"also":[139,153],"large":[141,223],"shifts.":[143],"Duper":[144],"mutants":[145,260],"that":[146,165,183,195,312],"were":[147],"born":[148],"raised":[150],"DD":[152],"pulses,":[163],"indicating":[164,194],"PRC":[172,239],"not":[175,189,271],"an":[176],"aftereffect":[177],"14L:10D.":[181],"Hamsters":[182],"are":[184],"heterozygous":[185],"for":[186,196,200],"do":[188],"amplified":[191],"curves,":[193],"property,":[198],"determination":[201],"period,":[204],"allele":[207],"recessive.":[209],"modified":[212],"Aschoff":[213],"type":[214],"II":[215],"protocol,":[216],"shifts":[225],"soon":[227],"second":[230],"day":[231],"Despite":[234],"amplification":[236],"hamsters,":[243],"induction":[245,298],"Period1":[247],"gene":[248],"expression":[249,266],"SCN":[252,269,301],"no":[256],"greater":[257,296],"these":[259],"than":[261],"animals.":[264,308],"Period2":[265],"did":[270],"differ":[272],"between":[273],"exposed":[279],"at":[282],"CT15,":[283],"but":[284],"albumin":[285],"site":[286],"D-binding":[287],"protein":[288],"(Dbp)":[289],"mRNA":[290],"higher":[292],"basal":[293],"levels":[294],"compared":[305],"These":[309],"results":[310],"indicate":[311],"alters":[316],"oscillator":[322],"further":[324],"distinguish":[325],"it":[326],"from":[327],"mutation.":[330]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}