{"id":"https://openalex.org/W2044454459","doi":"https://doi.org/10.1212/wnl.38.7.1060","title":"Prolonged survival and partial recovery in AIDS\u2010associated progressive multifocal leukoencephalopathy","display_name":"Prolonged survival and partial recovery in AIDS\u2010associated progressive multifocal leukoencephalopathy","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W2044454459","doi":"https://doi.org/10.1212/wnl.38.7.1060","mag":"2044454459","pmid":"https://pubmed.ncbi.nlm.nih.gov/3386823"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.38.7.1060","doi":"https://doi.org/10.1212/wnl.38.7.1060","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.38.7.1060","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066505115","display_name":"Joseph R. Berger","orcid":"https://orcid.org/0000-0002-1540-496X","observed_orcids":["https://orcid.org/0000-0002-1540-496X","https://orcid.org/0000-0002-3821-1749","https://orcid.org/0000-0002-0260-2430"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Berger","raw_affiliation_strings":["From the Departments of Neurology and Internal Medicine (Dr. Berger), University of Miami School of Medicine, Miami, FL, and the Department of Neurology (Dr. Mucke), Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology and Internal Medicine (Dr. Berger), University of Miami School of Medicine, Miami, FL, and the Department of Neurology (Dr. Mucke), Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I145608581","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065986296","display_name":"Lennart Mucke","orcid":"https://orcid.org/0000-0001-6256-9559","observed_orcids":["https://orcid.org/0000-0001-6256-9559"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lennart Mucke","raw_affiliation_strings":["From the Departments of Neurology and Internal Medicine (Dr. Berger), University of Miami School of Medicine, Miami, FL, and the Department of Neurology (Dr. Mucke), Massachusetts General Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology and Internal Medicine (Dr. Berger), University of Miami School of Medicine, Miami, FL, and the Department of Neurology (Dr. Mucke), Massachusetts General Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I145608581","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3817,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.83864143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"38","issue":"7","first_page":"1060","last_page":"1060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.6779999732971191},{"id":"https://openalex.org/keywords/neurological-recovery","display_name":"neurological recovery","score":0.871999979019165},{"id":"https://openalex.org/keywords/prolonged-survival","display_name":"survival prolongation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.7950000166893005},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/stereotactic-biopsy","display_name":"stereotactic biopsy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.9529228210449219},{"id":"https://openalex.org/C2779150272","wikidata":"https://www.wikidata.org/wiki/Q1676563","display_name":"JC virus","level":4,"score":0.7828817367553711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7545783519744873},{"id":"https://openalex.org/C2778583010","wikidata":"https://www.wikidata.org/wiki/Q3237081","display_name":"Leukoencephalopathy","level":3,"score":0.7341105937957764},{"id":"https://openalex.org/C2776429142","wikidata":"https://www.wikidata.org/wiki/Q1620189","display_name":"Brain biopsy","level":3,"score":0.6088961362838745},{"id":"https://openalex.org/C2779196057","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic infection","level":4,"score":0.47062042355537415},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.46973833441734314},{"id":"https://openalex.org/C148632171","wikidata":"https://www.wikidata.org/wiki/Q7542129","display_name":"Slow virus","level":4,"score":0.4184880256652832},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.38283005356788635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.335000216960907},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33220335841178894},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3276359736919403},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.24974074959754944},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24918365478515625},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07372328639030457}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.38.7.1060","doi":"https://doi.org/10.1212/wnl.38.7.1060","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.38.7.1060","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:3386823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3386823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2120286213","https://openalex.org/W2316744245","https://openalex.org/W2027608570","https://openalex.org/W2142898560","https://openalex.org/W1910202434","https://openalex.org/W2425740281","https://openalex.org/W2111862028","https://openalex.org/W2091851142","https://openalex.org/W1987298388","https://openalex.org/W2120054836"],"abstract_inverted_index":{"Two":[0],"human":[1],"immunodeficiency":[2],"virus":[3],"seropositive":[4],"patients":[5,61],"with":[6,89,119],"progressive":[7],"multifocal":[8],"leukoencephalopathy":[9],"(PML)":[10],"exhibited":[11],"a":[12],"dramatic":[13],"though":[14,48],"incomplete":[15],"recovery":[16,103],"of":[17,31,38,70,94,107],"neurologic":[18,102],"function":[19],"and":[20],"have":[21,52],"survived":[22],"for":[23],"more":[24],"than":[25],"30":[26],"months":[27],"since":[28],"the":[29,35,39,67,105],"onset":[30],"symptoms.":[32],"PML":[33,113],"was":[34,73],"initial":[36],"manifestation":[37],"acquired":[40],"immune":[41],"deficiency":[42],"syndrome":[43],"(AIDS)":[44],"in":[45,55,114],"both":[46,60],"patients,":[47],"other":[49,108],"opportunistic":[50,109],"infections":[51],"subsequently":[53],"supervened":[54],"one.":[56],"Brain":[57],"tissue":[58],"from":[59],"obtained":[62],"by":[63,76],"stereotactic":[64],"biopsy":[65],"showed":[66],"typical":[68],"features":[69],"PML,":[71],"but":[72],"also":[74],"characterized":[75],"an":[77],"unusually":[78],"prominent":[79],"inflammatory":[80],"response.":[81],"Neurologic":[82],"improvement":[83],"did":[84],"not":[85],"appear":[86],"to":[87,100],"correlate":[88],"clinical":[90],"or":[91],"laboratory":[92],"measurements":[93],"immunologic":[95],"improvement.":[96],"One":[97],"patient":[98],"continued":[99],"display":[101],"despite":[104],"development":[106],"infections.":[110],"Though":[111],"atypical,":[112],"AIDS":[115],"may":[116],"be":[117],"associated":[118],"prolonged":[120],"survival.":[121]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
