{"id":"https://openalex.org/W2044453689","doi":"https://doi.org/10.1089/sur.2011.062","title":"Linezolid and Vancomycin in Treatment of Lower-Extremity Complicated Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus in Patients with and without Vascular Disease","display_name":"Linezolid and Vancomycin in Treatment of Lower-Extremity Complicated Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus in Patients with and without Vascular Disease","publication_year":2012,"publication_date":"2012-05-08","ids":{"openalex":"https://openalex.org/W2044453689","doi":"https://doi.org/10.1089/sur.2011.062","mag":"2044453689","pmid":"https://pubmed.ncbi.nlm.nih.gov/22568921"},"language":"en","primary_location":{"id":"doi:10.1089/sur.2011.062","doi":"https://doi.org/10.1089/sur.2011.062","is_oa":false,"landing_page_url":"https://doi.org/10.1089/sur.2011.062","pdf_url":null,"source":{"id":"https://openalex.org/S182167790","display_name":"Surgical Infections","issn_l":"1096-2964","issn":["1096-2964","1557-8674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Infections","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109382813","display_name":"Ther\u00e8se M. Duane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ther\u00e8se M. Duane","raw_affiliation_strings":["Department of Surgery, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112900164","display_name":"John A. Weigelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Weigelt","raw_affiliation_strings":["Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009305511","display_name":"Laura Puzniak","orcid":"https://orcid.org/0000-0001-8697-9683","observed_orcids":["https://orcid.org/0000-0001-8697-9683"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A. Puzniak","raw_affiliation_strings":["Pfizer Inc, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016570350","display_name":"David B. Huang","orcid":"https://orcid.org/0000-0001-8228-7911","observed_orcids":["https://orcid.org/0000-0001-8228-7911","https://orcid.org/0000-0002-8342-3193"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Huang","raw_affiliation_strings":["Formerly of Pfizer Inc, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formerly of Pfizer Inc, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109382813"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"],"apc_list":null,"apc_paid":null,"fwci":2.0626,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.85892857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"3","first_page":"147","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":1.0},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9399999976158142},{"id":"https://openalex.org/keywords/complicated-skin-and-skin-structure-infections","display_name":"complicated skin and skin structure infections","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lower-limb-infection","display_name":"lower limb infection","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/antibiotic-efficacy","display_name":"antibiotic efficacy","score":0.49900001287460327},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7870000004768372},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.9463942050933838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9422693252563477},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.8747528195381165},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6156756281852722},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.5192782878875732},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4974532425403595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4328606426715851},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069349","descriptor_name":"Linezolid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013207","descriptor_name":"Staphylococcal Skin Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/sur.2011.062","doi":"https://doi.org/10.1089/sur.2011.062","is_oa":false,"landing_page_url":"https://doi.org/10.1089/sur.2011.062","pdf_url":null,"source":{"id":"https://openalex.org/S182167790","display_name":"Surgical Infections","issn_l":"1096-2964","issn":["1096-2964","1557-8674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Infections","raw_type":"journal-article"},{"id":"pmid:22568921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22568921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical infections","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1991721421","https://openalex.org/W2002188750","https://openalex.org/W2010317311","https://openalex.org/W2012746689","https://openalex.org/W2019123006","https://openalex.org/W2019324782","https://openalex.org/W2019351961","https://openalex.org/W2031446763","https://openalex.org/W2083299338","https://openalex.org/W2084025044","https://openalex.org/W2089946259","https://openalex.org/W2090874066","https://openalex.org/W2099008206","https://openalex.org/W2100049802","https://openalex.org/W2105206884","https://openalex.org/W2106462772","https://openalex.org/W2117409056","https://openalex.org/W2121423505","https://openalex.org/W2137631111","https://openalex.org/W2144985796","https://openalex.org/W2167558599","https://openalex.org/W2315193427"],"related_works":["https://openalex.org/W2019351961","https://openalex.org/W1987653198","https://openalex.org/W2006555196","https://openalex.org/W2149993789","https://openalex.org/W2050281616","https://openalex.org/W2163396611","https://openalex.org/W2345698662","https://openalex.org/W2189091662","https://openalex.org/W2100886773","https://openalex.org/W3136451045"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,38],"evaluated":[2],"drug":[3],"efficacy":[4,48],"and":[5,10,26,49,62,104,112,130,141,172,196],"safety":[6,50,185,192],"among":[7],"patients":[8,86,90,108,116,135,170],"with":[9,17,91,110,171,189],"without":[11,117,173],"vascular":[12,92,118,161,174],"disease":[13,93,119,175],"who":[14,151,176],"were":[15,84,187],"treated":[16,109],"linezolid":[18,52,111,195],"or":[19,57,66,158],"vancomycin":[20,63,96,122,197],"for":[21,73,87,107,169,199],"a":[22,178],"lower-extremity":[23,179],"complicated":[24],"skin":[25,27],"structure":[28],"infection":[29],"(cSSSI)":[30],"caused":[31,78,181],"by":[32,79,182],"methicillin-resistant":[33],"Staphylococcus":[34],"aureus":[35],"(MRSA).":[36],"METHODS:":[37],"pooled":[39],"data":[40,186],"from":[41],"two":[42],"randomized":[43],"clinical":[44,99,125],"trials":[45],"evaluating":[46],"the":[47,74,98,124,156,190],"of":[51,76,155,160,194],"600":[53],"mg":[54],"intravenously":[55],"(IV)":[56],"orally":[58],"every":[59,70],"12":[60,71],"h":[61,72],"15":[64],"mg/kg":[65],"1":[67],"g":[68],"IV":[69,138],"treatment":[75,168],"cSSSI":[77,180],"culture-proved":[80],"MRSA.":[81,183],"RESULTS:":[82],"There":[83],"477":[85],"analysis.":[88],"Among":[89,115],"(linezolid":[94,120],"n=139,":[95],"n=135),":[97],"success":[100,126],"rate":[101,127],"was":[102,128],"80.4%":[103],"66.7%":[105],"(p=0.02)":[106],"vancomycin,":[113,153],"respectively.":[114],"n=91,":[121],"n=112),":[123],"94.5%":[129],"89.4%,":[131],"respectively":[132],"(p=0.24).":[133],"Linezolid-treated":[134],"had":[136],"fewer":[137],"catheter-site":[139],"complications":[140],"less":[142],"kidney":[143],"impairment":[144],"but":[145],"more":[146],"frequent":[147],"thrombocytopenia":[148],"than":[149],"those":[150],"received":[152],"regardless":[154],"presence":[157],"absence":[159],"disease.":[162],"CONCLUSION:":[163],"Linezolid":[164],"is":[165],"an":[166],"effective":[167],"have":[177],"The":[184],"consistent":[188],"known":[191],"profiles":[193],"given":[198],"this":[200],"indication.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}