{"id":"https://openalex.org/W2044219252","doi":"https://doi.org/10.1074/jbc.273.46.30218","title":"Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells","display_name":"Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2044219252","doi":"https://doi.org/10.1074/jbc.273.46.30218","mag":"2044219252","pmid":"https://pubmed.ncbi.nlm.nih.gov/9804779"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.46.30218","doi":"https://doi.org/10.1074/jbc.273.46.30218","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.46.30218","pdf_url":"http://www.jbc.org/article/S0021925819592250/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819592250/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009237974","display_name":"Hiroko Yamashita","orcid":"https://orcid.org/0000-0003-4281-8727","observed_orcids":["https://orcid.org/0000-0003-4281-8727"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroko Yamashita","raw_affiliation_strings":["Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053797937","display_name":"Jun Xu","orcid":"https://orcid.org/0000-0002-7140-7823","observed_orcids":["https://orcid.org/0000-0002-7140-7823"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Xu","raw_affiliation_strings":["Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011949596","display_name":"Rebecca A. Erwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Erwin","raw_affiliation_strings":["Department of Integrative Biology, Pharmacology, and Physiology, University of Texas at Houston, Houston, Texas 77030","Intramural Research Support Program, Science Applications International Corp.-Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, Pharmacology, and Physiology, University of Texas at Houston, Houston, Texas 77030","institution_ids":[]},{"raw_affiliation_string":"Intramural Research Support Program, Science Applications International Corp.-Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012494061","display_name":"William L. Farrar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William L. Farrar","raw_affiliation_strings":["Division of Basic Sciences, Laboratory of Molecular Immunoregulation, NCI-Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Laboratory of Molecular Immunoregulation, NCI-Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027085103","display_name":"Robert Arthur Kirken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Kirken","raw_affiliation_strings":["Department of Integrative Biology, Pharmacology, and Physiology, University of Texas at Houston, Houston, Texas 77030","Intramural Research Support Program, Science Applications International Corp.-Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, Pharmacology, and Physiology, University of Texas at Houston, Houston, Texas 77030","institution_ids":[]},{"raw_affiliation_string":"Intramural Research Support Program, Science Applications International Corp.-Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065798455","display_name":"Hallgeir Rui","orcid":"https://orcid.org/0000-0002-8778-261X","observed_orcids":["https://orcid.org/0000-0002-8778-261X"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hallgeir Rui","raw_affiliation_strings":["Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5065798455"],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.8066,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.96604215,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"273","issue":"46","first_page":"30218","last_page":"30224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat5a","display_name":"STAT5A","score":0.9290000200271606},{"id":"https://openalex.org/keywords/stat5b","display_name":"STAT5B","score":1.0},{"id":"https://openalex.org/keywords/serine-phosphorylation","display_name":"serine phosphorylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prolactin-signaling","display_name":"prolactin signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.8389999866485596},{"id":"https://openalex.org/keywords/map-kinase-inhibition","display_name":"MAP kinase inhibition","score":0.6019999980926514},{"id":"https://openalex.org/keywords/constitutive-phosphorylation","display_name":"constitutive phosphorylation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/transcription-factor-regulation","display_name":"transcription factor regulation","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8744170665740967},{"id":"https://openalex.org/C104551158","wikidata":"https://www.wikidata.org/wiki/Q7187581","display_name":"Phosphorylation cascade","level":5,"score":0.7022824287414551},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.6743780970573425},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.5245119333267212},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5088260769844055},{"id":"https://openalex.org/C2780307904","wikidata":"https://www.wikidata.org/wiki/Q2701649","display_name":"Phosphoserine","level":4,"score":0.5082868933677673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.502249002456665},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4305289089679718},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4195525050163269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38953498005867004},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.38016754388809204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3375932574272156}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019606","descriptor_name":"Phosphoamino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.46.30218","doi":"https://doi.org/10.1074/jbc.273.46.30218","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.46.30218","pdf_url":"http://www.jbc.org/article/S0021925819592250/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9804779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9804779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.46.30218","doi":"https://doi.org/10.1074/jbc.273.46.30218","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.46.30218","pdf_url":"http://www.jbc.org/article/S0021925819592250/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G390088705","display_name":"Prolactin Induced Phosphoprotein Signal Transduction","funder_award_id":"R01DK052013","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8425065596","display_name":null,"funder_award_id":"R01 DK52013-01A1","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332504","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2044219252.pdf","grobid_xml":"https://content.openalex.org/works/W2044219252.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W4553897","https://openalex.org/W77986286","https://openalex.org/W326967406","https://openalex.org/W334134150","https://openalex.org/W1483871091","https://openalex.org/W1486018587","https://openalex.org/W1507957953","https://openalex.org/W1543158853","https://openalex.org/W1550156431","https://openalex.org/W1942718916","https://openalex.org/W1958363133","https://openalex.org/W1967301981","https://openalex.org/W1975687767","https://openalex.org/W1977164998","https://openalex.org/W1983823652","https://openalex.org/W1984459365","https://openalex.org/W1984486504","https://openalex.org/W1994479081","https://openalex.org/W1998051987","https://openalex.org/W2013691481","https://openalex.org/W2021927710","https://openalex.org/W2030865745","https://openalex.org/W2044671573","https://openalex.org/W2045427520","https://openalex.org/W2058554631","https://openalex.org/W2058706806","https://openalex.org/W2059938714","https://openalex.org/W2068724210","https://openalex.org/W2074133165","https://openalex.org/W2083802827","https://openalex.org/W2086715846","https://openalex.org/W2096245547","https://openalex.org/W2103858832","https://openalex.org/W2104485296","https://openalex.org/W2140786721","https://openalex.org/W2147028876","https://openalex.org/W2403474134","https://openalex.org/W2423833205","https://openalex.org/W4313379474"],"related_works":["https://openalex.org/W2089914453","https://openalex.org/W1967301981","https://openalex.org/W2314865317","https://openalex.org/W1866222370","https://openalex.org/W1992575609","https://openalex.org/W2100394814","https://openalex.org/W1974392769","https://openalex.org/W1969460408","https://openalex.org/W2074133165","https://openalex.org/W1987259882"],"abstract_inverted_index":{"Transcription":[0],"factors":[1],"of":[2,12,30,54,76,91,104,106,119,131,155,206,210,223,236,242],"the":[3,82,117,132,207],"Stat":[4,21],"family":[5],"are":[6],"controlled":[7],"by":[8,111,137,141],"protein":[9,151],"kinases.":[10,152],"Phosphorylation":[11],"a":[13,50,120,224],"positionally":[14],"conserved":[15,51],"tyrosine":[16],"residue":[17],"is":[18,188,195],"obligatory":[19],"for":[20,217],"dimerization,":[22],"nuclear":[23],"translocation,":[24],"and":[25,32,57,69,86,100,190,192,198,200,244],"specific":[26],"DNA":[27,218],"binding.":[28],"Studies":[29],"Stat1":[31,243],"Stat3":[33],"have":[34],"suggested":[35,116],"that":[36,179,187,194,232,241],"serine":[37,46,123,184,233],"phosphorylation":[38,62,74,103,124,130,205],"may":[39],"also":[40,115],"regulate":[41,182],"function.":[42],"We":[43,177],"now":[44],"identify":[45],"residues":[47],"located":[48],"in":[49,97,126,145,228],"PSP":[52,78,133,208],"motif":[53,79,134,209],"Stat5a":[55,85,92,167,211],"(Ser725)":[56],"Stat5b":[58,87,107,169,213],"(Ser730)":[59],"as":[60],"major":[61,122],"sites,":[63],"using":[64],"mutagenesis,":[65],"phosphoamino":[66],"acid":[67],"analysis,":[68],"site-specific":[70],"anti-Stat5-phosphoserine":[71],"antibodies.":[72],"Unexpectedly,":[73],"control":[75,235],"this":[77],"differed":[80],"between":[81],"highly":[83],"homologous":[84],"proteins.":[88],"Whereas":[89],"Ser725":[90],"was":[93,108,135,214],"constitutively":[94,196],"phosphorylated":[95],"both":[96,147],"COS-7":[98,229],"cells":[99,156],"Nb2":[101],"lymphocytes,":[102],"Ser730":[105],"markedly":[109],"stimulated":[110],"prolactin.":[112],"The":[113],"data":[114],"existence":[118],"second":[121],"site":[125],"Stat5a.":[127,203],"Interestingly,":[128],"constitutive":[129],"suppressed":[136],"PD98059":[138],"but":[139],"not":[140,164,215],"staurosporine":[142],"under":[143],"conditions":[144],"which":[146],"agents":[148],"inhibited":[149],"mitogen-activated":[150],"Furthermore,":[153],"pretreatment":[154],"with":[157],"staurosporine,":[158],"PD98059,":[159],"H7,":[160],"or":[161,168,212,220],"wortmannin":[162],"did":[163],"prevent":[165],"either":[166],"from":[170,240],"becoming":[171],"maximally":[172],"serine-phosphorylated":[173],"after":[174],"prolactin":[175],"exposure.":[176],"propose":[178],"two":[180],"pathways":[181],"Stat5":[183,237],"phosphorylation,":[185],"one":[186,193],"prolactin-activated":[189],"PD98059-resistant":[191],"active":[197],"PD98059-sensitive":[199],"preferentially":[201],"targets":[202],"Finally,":[204],"essential":[216],"binding":[219],"transcriptional":[221],"activation":[222],"beta-casein":[225],"reporter":[226],"gene":[227],"cells,":[230],"suggesting":[231],"kinase":[234],"activity":[238],"differs":[239],"Stat3.":[245]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
