{"id":"https://openalex.org/W2044120237","doi":"https://doi.org/10.1021/jf901278u","title":"Effects of Coffee on Inflammatory Cytokine Gene Expression in Mice Fed High-Fat Diets","display_name":"Effects of Coffee on Inflammatory Cytokine Gene Expression in Mice Fed High-Fat Diets","publication_year":2009,"publication_date":"2009-11-09","ids":{"openalex":"https://openalex.org/W2044120237","doi":"https://doi.org/10.1021/jf901278u","mag":"2044120237","pmid":"https://pubmed.ncbi.nlm.nih.gov/19899759"},"language":"en","primary_location":{"id":"doi:10.1021/jf901278u","doi":"https://doi.org/10.1021/jf901278u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf901278u","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084320114","display_name":"Yoichi Fukushima","orcid":"https://orcid.org/0000-0002-9259-3207","observed_orcids":["https://orcid.org/0000-0002-9259-3207"]},"institutions":[{"id":"https://openalex.org/I4405262739","display_name":"All Japan Coffee Association","ror":"https://ror.org/04ypwve02","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405262739"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoichi Fukushima","raw_affiliation_strings":["All Japan Coffee Association, Tokyo, Japan. qzc04363@nifty.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All Japan Coffee Association, Tokyo, Japan. qzc04363@nifty.com","institution_ids":["https://openalex.org/I4405262739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091408750","display_name":"Masato Kasuga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Kasuga","raw_affiliation_strings":["Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105832217","display_name":"Kazuwa Nakao","orcid":"https://orcid.org/0000-0003-3483-4196","observed_orcids":["https://orcid.org/0000-0003-3483-4196"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuwa Nakao","raw_affiliation_strings":["Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037246488","display_name":"Iichiro Shimomura","orcid":"https://orcid.org/0000-0002-0851-9603","observed_orcids":["https://orcid.org/0000-0002-0851-9603"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iichiro Shimomura","raw_affiliation_strings":["Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109934217","display_name":"Y\u016bji Matsuzawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117281","display_name":"Sumitomo Hospital","ror":"https://ror.org/02m9ewz37","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210117281"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Matsuzawa","raw_affiliation_strings":["Sumitomo Hospital, Professor Emeritus Osaka University, 5-3-20 Nakanoshima, Kita-Ku, Osaka 530-0005, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sumitomo Hospital, Professor Emeritus Osaka University, 5-3-20 Nakanoshima, Kita-Ku, Osaka 530-0005, Japan","institution_ids":["https://openalex.org/I4210117281","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084320114"],"corresponding_institution_ids":["https://openalex.org/I4405262739"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0998,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.85276979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"57","issue":"23","first_page":"11100","last_page":"11105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coffee","display_name":"coffee","score":0.9670000076293945},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.6859999895095825},{"id":"https://openalex.org/keywords/decaffeinated-coffee","display_name":"decaffeinated coffee","score":0.9739999771118164},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9330000281333923},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.953000009059906},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9670000076293945},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8370000123977661},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7540000081062317},{"id":"https://openalex.org/keywords/mesenteric-fat","display_name":"mesenteric fat","score":0.7799999713897705},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.7889999747276306},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6973787546157837},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5898430347442627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5525861382484436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4841485619544983},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.463714599609375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33606523275375366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22631573677062988}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003069","descriptor_name":"Coffee","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jf901278u","doi":"https://doi.org/10.1021/jf901278u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf901278u","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:19899759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19899759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970557707","https://openalex.org/W4361212183","https://openalex.org/W2019065328","https://openalex.org/W2041045280","https://openalex.org/W2520283566","https://openalex.org/W3207347307","https://openalex.org/W1997073064","https://openalex.org/W3134938264","https://openalex.org/W1972723860","https://openalex.org/W2030628693"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,127,221],"investigate":[3],"the":[4,79,88,100,114,119,131,136,152,159,176,183,204,223],"risk-reducing":[5],"effects":[6],"of":[7,76,102,212,225],"coffee":[8,24,70,217],"in":[9,16,29,78,99,105,113,118,130,135,151,158,171,175,182,195,203],"metabolic":[10,226],"syndrome,":[11],"we":[12],"performed":[13],"a":[14,19,47,52,58],"study":[15],"mice":[17,39,77],"fed":[18],"high-fat":[20,53,59],"diet":[21,49,54,60,103],"with":[22,61],"added":[23],"and":[25,31,81,90,125,143,154,179,185],"analyzed":[26],"gene":[27,169,193],"expression":[28,170,194],"liver":[30,172],"adipose":[32,197],"tissues":[33],"using":[34],"cDNA":[35],"microarray.":[36],"Male":[37],"C57BL/6J":[38],"were":[40,84,96,148],"raised":[41],"for":[42],"8":[43],"weeks":[44],"on":[45],"either":[46],"normal":[48],"(N":[50],"group),":[51,56],"(HF":[55],"or":[57,66],"1.1%":[62,67],"decaffeinated":[63],"(HF+DC":[64],"group)":[65],"caffeine-containing":[68],"instant":[69],"(HF+CC":[71],"group).":[72],"The":[73,210],"body":[74],"weights":[75],"HF+DC":[80,115,153,184,205],"HF+CC":[82,132,155,186],"groups":[83,156,187],"mostly":[85],"intermediate":[86],"between":[87],"N":[89],"HF":[91,120,137,160,177],"groups,":[92],"even":[93],"if":[94],"there":[95],"no":[97],"difference":[98],"amount":[101],"consumption":[104,218],"each":[106],"group.":[107,138],"Mesenteric":[108],"fat":[109],"weight":[110],"was":[111,173,199],"lower":[112,129,150],"group":[116,121,133,161,178,206],"than":[117,134,157],"(p":[122,162,188,207],"<":[123,163,189,208],"0.05)":[124],"tended":[126],"become":[128],"Serum":[139],"aspartate":[140],"aminotransferase":[141,145],"(AST)":[142],"alanine":[144],"(ALT)":[146],"levels":[147],"significantly":[149,180,201],"0.05).":[164],"Inflammatory":[165],"cytokine":[166],"interleukin":[167],"(IL)-1beta":[168],"up-regulated":[174],"down-regulated":[181],"0.01),":[190],"while":[191],"MCP-1":[192],"white":[196],"tissue":[198],"also":[200],"suppressed":[202],"0.01).":[209],"induction":[211],"these":[213],"anti-inflammatory":[214],"responses":[215],"by":[216],"may":[219],"contribute":[220],"reducing":[222],"risks":[224],"syndrome.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
