{"id":"https://openalex.org/W2044053202","doi":"https://doi.org/10.1158/0008-5472.sabcs13-es04-1","title":"Abstract ES04-1: Basic science 101 \u2013 Targeting cell signaling in breast cancer","display_name":"Abstract ES04-1: Basic science 101 \u2013 Targeting cell signaling in breast cancer","publication_year":2013,"publication_date":"2013-12-15","ids":{"openalex":"https://openalex.org/W2044053202","doi":"https://doi.org/10.1158/0008-5472.sabcs13-es04-1","mag":"2044053202"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.sabcs13-es04-1","doi":"https://doi.org/10.1158/0008-5472.sabcs13-es04-1","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-es04-1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033966004","display_name":"Douglas Yee","orcid":"https://orcid.org/0000-0002-3387-4009","observed_orcids":["https://orcid.org/0000-0002-3387-4009"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D Yee","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033966004"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"24_Supplement","first_page":"ES04","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5752000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5752000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.21480000019073486,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.07360000163316727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":1.0},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.9129999876022339},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.8949999809265137},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6102491021156311},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5933709144592285},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5651035308837891},{"id":"https://openalex.org/C2781164504","wikidata":"https://www.wikidata.org/wiki/Q1998021","display_name":"Pertuzumab","level":5,"score":0.5529987215995789},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5438012480735779},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.47638219594955444},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.46490681171417236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4633294939994812},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4548398554325104},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45347076654434204},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.4343544542789459},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.42884135246276855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3929167687892914},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33168649673461914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28817787766456604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21171528100967407}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.sabcs13-es04-1","doi":"https://doi.org/10.1158/0008-5472.sabcs13-es04-1","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-es04-1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086117273","https://openalex.org/W1967055906","https://openalex.org/W2054165300","https://openalex.org/W2966461092","https://openalex.org/W2490996614","https://openalex.org/W7099490033","https://openalex.org/W1975041336","https://openalex.org/W2001033586","https://openalex.org/W2504015701","https://openalex.org/W2017441789"],"abstract_inverted_index":{"Abstract":[0,253],"Since":[1],"normal":[2,37,135],"cells":[3,17],"require":[4],"extracellular":[5],"signals":[6,113],"to":[7,21,147],"proliferate,":[8],"it":[9],"seems":[10],"likely":[11],"that":[12,110,160,179],"some":[13],"transformed":[14],"breast":[15],"cancer":[16],"can":[18],"still":[19],"respond":[20],"these":[22,60,149],"signals.":[23],"This":[24],"premise":[25],"is":[26,114,157],"now":[27],"well":[28],"established;":[29],"disruption":[30,69],"of":[31,58,70,93,95,101,119,162,196,242],"estrogen":[32,42,51,180,243],"receptor":[33,52,181,244],"function,":[34],"important":[35],"in":[36,153,204],"mammary":[38],"gland":[39],"biology,":[40],"by":[41,78,207],"deprivation":[43],"(ovarian":[44],"suppression":[45],"or":[46,49,164],"aromatase":[47],"inhibition)":[48],"selective":[50],"modulators":[53],"demonstrated":[54],"the":[55,68,71,99,120,125,177,191,194,239],"clinical":[56,154,187,213],"value":[57,188,216],"interrupting":[59],"key":[61],"signaling":[62,97,108,225],"pathways.":[63,198],"Further":[64],"advances":[65,200],"have":[66,86,144,168,201,215],"included":[67],"human":[72],"epidermal":[73],"growth":[74],"factor":[75],"2":[76],"(HER2)":[77],"monoclonal":[79],"antibodies":[80],"and":[81,124,136,142,151,183,210,232,245],"tyrosine":[82],"kinases.":[83],"These":[84,212],"successes":[85],"generated":[87],"greater":[88],"enthusiasm":[89],"for":[90,134,193],"identifying":[91,102],"mechanism":[92],"action":[94],"cell":[96,138,224],"with":[98],"hope":[100],"new":[103,163],"therapeutic":[104],"targets.":[105],"The":[106],"intracellular":[107],"pathways":[109,131,150,166],"transduce":[111],"proliferative":[112],"becoming":[115],"better":[116],"understood.":[117],"Activation":[118],"phosphatidyl":[121],"3-kinase":[122],"(PI3K)":[123],"mitogen":[126],"activated":[127],"protein":[128],"kinase":[129],"(MAPK)":[130],"are":[132,152],"required":[133],"malignant":[137],"growth.":[139],"Multiple":[140],"strategies":[141,214,233],"drugs":[143],"been":[145,202],"developed":[146],"target":[148],"trial.":[155],"It":[156],"also":[158,167],"evident":[159],"co-targeting":[161],"established":[165,240],"utility":[169],"over":[170],"targeting":[171,182,205],"only":[172],"one":[173],"molecule.":[174],"For":[175],"example,":[176],"demonstration":[178],"mTOR":[184],"inhibition":[185,195],"has":[186,189],"revealed":[190],"potential":[192],"multiple":[197],"Similar":[199],"made":[203],"HER2":[206],"both":[208],"trastuzumab":[209],"pertuzumab.":[211],"as":[217],"combination":[218],"therapy":[219],"may":[220],"more":[221],"fully":[222],"suppress":[223],"than":[226],"single":[227],"agent":[228],"therapy.":[229],"Additional":[230],"concepts":[231],"will":[234],"be":[235],"discussed":[236],"based":[237],"on":[238],"targets":[241],"HER2.":[246],"Citation":[247],"Information:":[248],"Cancer":[249],"Res":[250],"2013;73(24":[251],"Suppl):":[252],"nr":[254],"ES04-1.":[255]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
