{"id":"https://openalex.org/W2044041971","doi":"https://doi.org/10.1089/dna.1.1982.1.259","title":"Methylation of Mouse Ribosomal RNA Genes","display_name":"Methylation of Mouse Ribosomal RNA Genes","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2044041971","doi":"https://doi.org/10.1089/dna.1.1982.1.259","mag":"2044041971","pmid":"https://pubmed.ncbi.nlm.nih.gov/6301785"},"language":"en","primary_location":{"id":"doi:10.1089/dna.1.1982.1.259","doi":"https://doi.org/10.1089/dna.1.1982.1.259","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.1.1982.1.259","pdf_url":null,"source":{"id":"https://openalex.org/S4210174578","display_name":"DNA","issn_l":"0198-0238","issn":["0198-0238","2331-4672"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. GARRETT REILLY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. GARRETT REILLY","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109861002","display_name":"Charles A. Thomas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHARLES A. THOMAS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016683307","display_name":"Martha J. Lundell","orcid":"https://orcid.org/0000-0002-7239-9116","observed_orcids":["https://orcid.org/0000-0002-7239-9116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARTHA J. LUNDELL","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7003,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83702231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"3","first_page":"259","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-strains","display_name":"mouse strains","score":0.5770000219345093},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.7990000247955322},{"id":"https://openalex.org/keywords/akr-j-mice","display_name":"AKR/J mice","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypomethylation","display_name":"hypomethylation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/rdna-copy-number","display_name":"rDNA copy number","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tissue-specific-dna-methylation","display_name":"tissue-specific methylation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/f1-hybrids","display_name":"F1 hybrids","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.8332357406616211},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7314555048942566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7276181578636169},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7204558849334717},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.6181701421737671},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6058926582336426},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.578404426574707},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5368663668632507},{"id":"https://openalex.org/C207812311","wikidata":"https://www.wikidata.org/wiki/Q426560","display_name":"Ribosomal DNA","level":4,"score":0.5368025898933411},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39452189207077026},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25675010681152344},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.06432989239692688}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/dna.1.1982.1.259","doi":"https://doi.org/10.1089/dna.1.1982.1.259","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.1.1982.1.259","pdf_url":null,"source":{"id":"https://openalex.org/S4210174578","display_name":"DNA","issn_l":"0198-0238","issn":["0198-0238","2331-4672"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA","raw_type":"journal-article"},{"id":"pmid:6301785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6301785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA (Mary Ann Liebert, Inc.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W71597126","https://openalex.org/W1483688385","https://openalex.org/W1519629411","https://openalex.org/W1859788221","https://openalex.org/W1915926467","https://openalex.org/W1964628455","https://openalex.org/W1966468838","https://openalex.org/W1968542395","https://openalex.org/W1968793650","https://openalex.org/W1980451107","https://openalex.org/W1980612516","https://openalex.org/W1982786331","https://openalex.org/W1995777124","https://openalex.org/W2001019121","https://openalex.org/W2013639360","https://openalex.org/W2013902074","https://openalex.org/W2016197401","https://openalex.org/W2025450812","https://openalex.org/W2029987769","https://openalex.org/W2032799016","https://openalex.org/W2033328319","https://openalex.org/W2038305047","https://openalex.org/W2047254025","https://openalex.org/W2051406511","https://openalex.org/W2056169143","https://openalex.org/W2063252904","https://openalex.org/W2063450941","https://openalex.org/W2064390407","https://openalex.org/W2064815536","https://openalex.org/W2065603906","https://openalex.org/W2080488670","https://openalex.org/W2084754659","https://openalex.org/W2084863325","https://openalex.org/W2086955288","https://openalex.org/W2091602444","https://openalex.org/W2092177846","https://openalex.org/W2093896423","https://openalex.org/W2096006811","https://openalex.org/W2115399760","https://openalex.org/W2120890729","https://openalex.org/W2135005590","https://openalex.org/W2165008771","https://openalex.org/W2288319580"],"related_works":["https://openalex.org/W2047254025","https://openalex.org/W2076467621","https://openalex.org/W1996296207","https://openalex.org/W1999217617","https://openalex.org/W7100849098","https://openalex.org/W2290619300","https://openalex.org/W2033328319","https://openalex.org/W1970919179","https://openalex.org/W4213142639","https://openalex.org/W2116017139"],"abstract_inverted_index":{"Ribosomal":[0],"DNA":[1,75],"(rDNA)":[2],"methylation":[3,19,168,200],"was":[4],"studied":[5],"in":[6,101,117],"various":[7],"strains":[8],"of":[9,30,48,59,72,82,151,178,183],"mice.":[10],"We":[11],"used":[12],"restriction":[13],"enzymes":[14],"that":[15,77,158],"are":[16,79,97,107,123,127,134],"sensitive":[17],"to":[18,43,67],"and":[20,28,33,39,63,93,142,145,191,198],"a":[21,147,187],"cloned":[22],"probe":[23],"containing":[24],"the":[25,31,49,60,73,86,90,102,118,176],"transcribed":[26],"spacer":[27],"part":[29],"18S":[32],"28S":[34],"gene.":[35],"Strains":[36],"C3H/He3,":[37],"C57/B6-3,":[38],"AKR/J":[40,152,159,192],"were":[41],"found":[42],"have":[44],"less":[45],"than":[46,111],"9%":[47],"rDNA":[50,83,164,167,179],"methylated.":[51,69],"In":[52,85],"sharp":[53],"contrast,":[54],"Balb/c":[55,74,154,190],"mice":[56,185],"showed":[57,76,157,193],"30-50%":[58],"Hpa":[61,91,140],"II":[62,92,141],"Hha":[64,94,143],"I":[65,95,144],"sites":[66,96,106,113,122,137],"be":[68,172],"Further":[70],"study":[71],"there":[78,126],"three":[80],"groups":[81],"sequences.":[84],"first":[87],"group,":[88],"all":[89,108],"almost":[98],"completely":[99],"unmethylated;":[100],"second":[103],"group":[104,120],"these":[105],"methylated":[109],"(greater":[110],"30":[112],"for":[114,138],"each":[115],"enzyme);":[116],"third":[119],"most":[121],"methylated,":[124],"but":[125],"discrete":[128],"hypomethylation":[129,132],"sites.":[130],"These":[131],"positions":[133],"at":[135],"similar":[136],"both":[139,194],"show":[146],"tissue-specific":[148],"pattern.":[149],"Comparison":[150],"with":[153,175],"copy":[155,196],"level":[156,169],"had":[160],"about":[161],"60%":[162],"fewer":[163],"genes.":[165,180],"The":[166],"might":[170],"thus":[171],"correlated":[173],"directly":[174],"number":[177,197],"Finally,":[181],"analysis":[182],"F1":[184],"from":[186],"cross":[188],"between":[189],"low":[195,199],"levels.":[201]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}