{"id":"https://openalex.org/W2043987447","doi":"https://doi.org/10.1016/s1734-1140(11)70629-6","title":"Curcumin mediates presenilin-1 activity to reduce \u03b2-amyloid production in a model of Alzheimer\u2019s disease","display_name":"Curcumin mediates presenilin-1 activity to reduce \u03b2-amyloid production in a model of Alzheimer\u2019s disease","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2043987447","doi":"https://doi.org/10.1016/s1734-1140(11)70629-6","mag":"2043987447","pmid":"https://pubmed.ncbi.nlm.nih.gov/22180352"},"language":"en","primary_location":{"id":"doi:10.1016/s1734-1140(11)70629-6","doi":"https://doi.org/10.1016/s1734-1140(11)70629-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1734-1140(11)70629-6","pdf_url":null,"source":{"id":"https://openalex.org/S180401253","display_name":"Pharmacological Reports","issn_l":"1734-1140","issn":["1734-1140","2299-5684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048708975","display_name":"Xiong Zhang","orcid":"https://orcid.org/0000-0002-5957-7627","observed_orcids":["https://orcid.org/0000-0002-5957-7627"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Xiong","raw_affiliation_strings":["Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Chongqing Key Laboratory of Neurobiology","Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110375301","display_name":"Zhang Hongmei","orcid":"https://orcid.org/0000-0002-3991-3750","observed_orcids":["https://orcid.org/0000-0002-3991-3750"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Hongmei","raw_affiliation_strings":["Chongqing Key Laboratory of Neurobiology; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Chongqing Key Laboratory of Neurobiology","Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111782067","display_name":"Si Qi Lu","orcid":"https://orcid.org/0009-0005-9987-4019","observed_orcids":["https://orcid.org/0009-0005-9987-4019"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si Lu","raw_affiliation_strings":["Chongqing Key Laboratory of Neurobiology; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Chongqing Key Laboratory of Neurobiology","Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083429698","display_name":"Yu Li","orcid":"https://orcid.org/0000-0002-4844-3359","observed_orcids":["https://orcid.org/0000-0002-4844-3359"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Yu","raw_affiliation_strings":["Chongqing Key Laboratory of Neurobiology; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Chongqing Key Laboratory of Neurobiology","Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","Institute of Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Department of Pathology, Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience; Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Chongqing Key Laboratory of Neurobiology","institution_ids":[]},{"raw_affiliation_string":"Chongqing Medical University, Yuzhong District Yuanjiagang No. 1, 400016, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Institute of Neuroscience","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083429698"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":null,"fwci":4.1473,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.93638291,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"63","issue":"5","first_page":"1101","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6869999766349792},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8823573589324951},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.8328160047531128},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5532641410827637},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4823593497276306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4578569829463959},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.43223869800567627},{"id":"https://openalex.org/C3019216857","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"\u03b2 amyloid","level":4,"score":0.4246976375579834},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4119245409965515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3519635796546936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1905265748500824},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13194039463996887}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1734-1140(11)70629-6","doi":"https://doi.org/10.1016/s1734-1140(11)70629-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1734-1140(11)70629-6","pdf_url":null,"source":{"id":"https://openalex.org/S180401253","display_name":"Pharmacological Reports","issn_l":"1734-1140","issn":["1734-1140","2299-5684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reports","raw_type":"journal-article"},{"id":"pmid:22180352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22180352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological reports : PR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311041","display_name":"National Center for Theoretical Sciences","ror":"https://ror.org/02mfp0b67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W972110119","https://openalex.org/W1480987708","https://openalex.org/W1496316111","https://openalex.org/W1503968406","https://openalex.org/W1504655784","https://openalex.org/W1534001036","https://openalex.org/W1596069616","https://openalex.org/W1983924380","https://openalex.org/W1989630577","https://openalex.org/W1990411150","https://openalex.org/W2000902284","https://openalex.org/W2001380334","https://openalex.org/W2008376266","https://openalex.org/W2021871669","https://openalex.org/W2032920422","https://openalex.org/W2041082104","https://openalex.org/W2045243175","https://openalex.org/W2046209489","https://openalex.org/W2078064366","https://openalex.org/W2083633251","https://openalex.org/W2101230829","https://openalex.org/W2110662963","https://openalex.org/W4293242696"],"related_works":["https://openalex.org/W3200329470","https://openalex.org/W2387472504","https://openalex.org/W2565236170","https://openalex.org/W2370007060","https://openalex.org/W2371560949","https://openalex.org/W2148059849","https://openalex.org/W2001380334","https://openalex.org/W2979877769","https://openalex.org/W2043183526","https://openalex.org/W2060871029"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
