{"id":"https://openalex.org/W2043980528","doi":"https://doi.org/10.1074/jbc.m114.599662","title":"Crystal Structure of a Lipoxygenase in Complex with Substrate","display_name":"Crystal Structure of a Lipoxygenase in Complex with Substrate","publication_year":2014,"publication_date":"2014-09-18","ids":{"openalex":"https://openalex.org/W2043980528","doi":"https://doi.org/10.1074/jbc.m114.599662","mag":"2043980528","pmid":"https://pubmed.ncbi.nlm.nih.gov/25231982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4231669"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m114.599662","doi":"https://doi.org/10.1074/jbc.m114.599662","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.599662","pdf_url":"http://www.jbc.org/article/S0021925820332798/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820332798/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012938115","display_name":"David B. Neau","orcid":"https://orcid.org/0000-0002-6318-0876","observed_orcids":["https://orcid.org/0000-0002-6318-0876"]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Neau","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Cornell University, Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, Illinois 60439, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Cornell University, Northeastern Collaborative Access Team, Argonne National Laboratory, Argonne, Illinois 60439, and","institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054438126","display_name":"G\u00fcne\u015f Bender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunes Bender","raw_affiliation_strings":["Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075104884","display_name":"William E. Boeglin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Boeglin","raw_affiliation_strings":["Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072486705","display_name":"Sue G. Bartlett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue G. Bartlett","raw_affiliation_strings":["Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037990142","display_name":"ALAN R. BRASH","orcid":"https://orcid.org/0009-0003-2639-5848","observed_orcids":["https://orcid.org/0009-0003-2639-5848"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Brash","raw_affiliation_strings":["Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044618877","display_name":"Marcia E. Newcomer","orcid":"https://orcid.org/0000-0003-1219-9515","observed_orcids":["https://orcid.org/0000-0003-1219-9515"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcia E. Newcomer","raw_affiliation_strings":["Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803,. Electronic address: newcomer@lsu.edu","Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, 70803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803,. Electronic address: newcomer@lsu.edu","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, 70803","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044618877"],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.7778,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.9427773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"289","issue":"46","first_page":"31905","last_page":"31913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.10760000348091125,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0632999986410141,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"lipoxygenase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/enzyme-substrate-complex","display_name":"enzyme-substrate complex","score":0.9829999804496765},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.4819999933242798},{"id":"https://openalex.org/keywords/lipid-mediators","display_name":"lipid mediators","score":0.6539999842643738},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/isoform-selective-inhibitors","display_name":"isoform-selective inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cavity-depth","display_name":"cavity depth","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.7046862840652466},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6932563781738281},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.6785120964050293},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6512796878814697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5814762115478516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5537541508674622},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5046578645706177},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3711335062980652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23818954825401306},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001091","descriptor_name":"Arachidonate Lipoxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1074/jbc.m114.599662","doi":"https://doi.org/10.1074/jbc.m114.599662","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.599662","pdf_url":"http://www.jbc.org/article/S0021925820332798/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3615352","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4231669","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4231669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4231669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:25231982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25231982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.lsu.edu:biosci_pubs-3691","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/biosci_pubs/2692","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lsu.edu:chemistry_pubs-4430","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/chemistry_pubs/3419","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:biosci_pubs-3691","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/biosci_pubs/2692","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:chemistry_pubs-4430","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/chemistry_pubs/3419","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m114.599662","doi":"https://doi.org/10.1074/jbc.m114.599662","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.599662","pdf_url":"http://www.jbc.org/article/S0021925820332798/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1509819248","display_name":null,"funder_award_id":"GM 15431","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2053011652","display_name":null,"funder_award_id":"HL R01 107887","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2440397094","display_name":"Research Center for Pharmacology and Drug Toxicology","funder_award_id":"P50GM015431","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4455488328","display_name":"Research Center for Pharmacology & Drug Toxicology","funder_award_id":"P01GM015431","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7063165859","display_name":null,"funder_award_id":"HL R01 107887","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8647709140","display_name":"The Structural Basis for Control of 5-Lipoxgenease Activity","funder_award_id":"R01HL107887","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8813180579","display_name":"NE-CAT Center for Advanced Macromolecular Crystallography","funder_award_id":"P41GM103403","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000137775","display_name":null,"funder_award_id":"GM 15431","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043980528.pdf","grobid_xml":"https://content.openalex.org/works/W2043980528.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1145598662","https://openalex.org/W1531198291","https://openalex.org/W1532774873","https://openalex.org/W1546818135","https://openalex.org/W1975207791","https://openalex.org/W1979892619","https://openalex.org/W1986325227","https://openalex.org/W1992967202","https://openalex.org/W1993670933","https://openalex.org/W1994701129","https://openalex.org/W1998894809","https://openalex.org/W2001325096","https://openalex.org/W2010050353","https://openalex.org/W2011710650","https://openalex.org/W2016239417","https://openalex.org/W2030724193","https://openalex.org/W2031312398","https://openalex.org/W2032174759","https://openalex.org/W2041706446","https://openalex.org/W2043460275","https://openalex.org/W2045221081","https://openalex.org/W2052624151","https://openalex.org/W2054979333","https://openalex.org/W2056342195","https://openalex.org/W2059290956","https://openalex.org/W2061240784","https://openalex.org/W2065940005","https://openalex.org/W2074203890","https://openalex.org/W2076699828","https://openalex.org/W2082973874","https://openalex.org/W2083700811","https://openalex.org/W2096064309","https://openalex.org/W2097504850","https://openalex.org/W2104512614","https://openalex.org/W2108959691","https://openalex.org/W2110808180","https://openalex.org/W2129280925","https://openalex.org/W2144081223","https://openalex.org/W2147874841","https://openalex.org/W2157677688","https://openalex.org/W2163782474","https://openalex.org/W2170434288","https://openalex.org/W2171968520","https://openalex.org/W2180229411","https://openalex.org/W2580372907","https://openalex.org/W2786774014"],"related_works":["https://openalex.org/W2140616220","https://openalex.org/W2065940005","https://openalex.org/W4390146299","https://openalex.org/W1985006172","https://openalex.org/W1998894809","https://openalex.org/W1980519642","https://openalex.org/W2059445538","https://openalex.org/W2068758134","https://openalex.org/W2048310961","https://openalex.org/W2043429821"],"abstract_inverted_index":{"Lipoxygenases":[0],"(LOX)":[1],"play":[2],"critical":[3],"roles":[4],"in":[5,8,45,100,112,125,136],"mammalian":[6],"biology":[7],"the":[9,16,24,34,41,48,54,67,77,93,113,147,151],"generation":[10],"of":[11,15,26,33,36,47,53,70,76,98,116,122],"potent":[12],"lipid":[13],"mediators":[14],"inflammatory":[17],"response;":[18],"consequently,":[19],"they":[20],"are":[21,64],"targets":[22],"for":[23],"development":[25],"isoform-specific":[27],"inhibitors.":[28],"The":[29],"regio-":[30],"and":[31,85,141],"stereo-specificity":[32],"oxygenation":[35,69],"polyunsaturated":[37],"fatty":[38],"acids":[39],"by":[40],"enzymes":[42],"is":[43,57],"understood":[44],"terms":[46],"chemistry,":[49],"but":[50],"structural":[51,86],"observation":[52],"enzyme-substrate":[55,78],"interactions":[56],"lacking.":[58],"Although":[59],"several":[60],"LOX":[61],"crystal":[62],"structures":[63],"available,":[65],"heretofore":[66],"rapid":[68],"bound":[71],"substrate":[72,139],"has":[73],"precluded":[74],"capture":[75],"complex,":[79],"leaving":[80],"a":[81,126,134],"gap":[82],"between":[83],"chemical":[84],"insights.":[87],"In":[88],"this":[89],"report,":[90],"we":[91],"describe":[92],"2.0":[94],"\u00c5":[95],"resolution":[96],"structure":[97],"8R-LOX":[99],"complex":[101],"with":[102],"arachidonic":[103,123],"acid":[104,124],"obtained":[105],"under":[106],"anaerobic":[107],"conditions.":[108],"Subtle":[109],"rearrangements,":[110],"primarily":[111],"side":[114],"chains":[115],"three":[117],"amino":[118],"acids,":[119],"allow":[120],"binding":[121],"catalytically":[127],"competent":[128],"conformation.":[129],"Accompanying":[130],"experimental":[131],"work":[132],"supports":[133],"model":[135],"which":[137],"both":[138],"tethering":[140],"cavity":[142],"depth":[143],"contribute":[144],"to":[145],"positioning":[146],"appropriate":[148],"carbon":[149],"at":[150],"catalytic":[152],"machinery.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}