{"id":"https://openalex.org/W2043970785","doi":"https://doi.org/10.1016/s0168-3659(97)00187-9","title":"Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system","display_name":"Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2043970785","doi":"https://doi.org/10.1016/s0168-3659(97)00187-9","mag":"2043970785","pmid":"https://pubmed.ncbi.nlm.nih.gov/9685932"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-3659(97)00187-9","doi":"https://doi.org/10.1016/s0168-3659(97)00187-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-3659(97)00187-9","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011145110","display_name":"S.R. Jameela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800373951","display_name":"Sree Chitra Thirunal Institute for Medical Sciences and Technology","ror":"https://ror.org/05757k612","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2800373951"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S.R Jameela","raw_affiliation_strings":["Division of Polymer Chemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India","Division of Polymer Chemistry, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelnond Palace Campus, Trivandrum 695 012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Polymer Chemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India","institution_ids":["https://openalex.org/I2800373951"]},{"raw_affiliation_string":"Division of Polymer Chemistry, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelnond Palace Campus, Trivandrum 695 012, India","institution_ids":["https://openalex.org/I2800373951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111663316","display_name":"T. V. Kumary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800373951","display_name":"Sree Chitra Thirunal Institute for Medical Sciences and Technology","ror":"https://ror.org/05757k612","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2800373951"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"T.V. Kumary","raw_affiliation_strings":["Division of Pathophysiology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum 695 012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathophysiology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum 695 012, India","institution_ids":["https://openalex.org/I2800373951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067694139","display_name":"Arthur Vijayan Lal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800373951","display_name":"Sree Chitra Thirunal Institute for Medical Sciences and Technology","ror":"https://ror.org/05757k612","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2800373951"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A.V. Lal","raw_affiliation_strings":["Division of Vivarium, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum 695 012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vivarium, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum 695 012, India","institution_ids":["https://openalex.org/I2800373951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059239787","display_name":"A. Jayakrishnan","orcid":"https://orcid.org/0000-0003-2738-6161","observed_orcids":["https://orcid.org/0000-0003-2738-6161"]},"institutions":[{"id":"https://openalex.org/I2800373951","display_name":"Sree Chitra Thirunal Institute for Medical Sciences and Technology","ror":"https://ror.org/05757k612","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2800373951"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"A. Jayakrishnan","raw_affiliation_strings":["Division of Polymer Chemistry, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelnond Palace Campus, Trivandrum 695 012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Polymer Chemistry, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelnond Palace Campus, Trivandrum 695 012, India","institution_ids":["https://openalex.org/I2800373951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059239787"],"corresponding_institution_ids":["https://openalex.org/I2800373951"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":3.3748,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.92275862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"52","issue":"1-2","first_page":"17","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chitosan-microparticles","display_name":"chitosan microspheres","score":1.0},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.8999999761581421},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.7549999952316284},{"id":"https://openalex.org/keywords/crosslink-density","display_name":"crosslink density","score":0.9559999704360962},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.7149999737739563},{"id":"https://openalex.org/keywords/in-vivo-bioavailability","display_name":"in vivo bioavailability","score":0.6940000057220459},{"id":"https://openalex.org/keywords/biodegradable-microspheres","display_name":"biodegradable microspheres","score":0.7929999828338623},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/burst-release","display_name":"burst release","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.8186283707618713},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7985926866531372},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5828441977500916},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5198022127151489},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5153226256370544},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5081393718719482},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4397393763065338},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.42502668499946594},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.409252405166626},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.35493403673171997},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.35296565294265747},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1498589813709259},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10031571984291077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001673","descriptor_name":"Biodegradation, Environmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0168-3659(97)00187-9","doi":"https://doi.org/10.1016/s0168-3659(97)00187-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-3659(97)00187-9","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:9685932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9685932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W138577744","https://openalex.org/W653459322","https://openalex.org/W1486941384","https://openalex.org/W1492028072","https://openalex.org/W1546516026","https://openalex.org/W1549884146","https://openalex.org/W1595269793","https://openalex.org/W1609778927","https://openalex.org/W1809452114","https://openalex.org/W1966759483","https://openalex.org/W1967203266","https://openalex.org/W1979982507","https://openalex.org/W1996908608","https://openalex.org/W2021526189","https://openalex.org/W2027308511","https://openalex.org/W2053414134","https://openalex.org/W2057057376","https://openalex.org/W2061323050","https://openalex.org/W2061509259","https://openalex.org/W2086130473","https://openalex.org/W2086645341","https://openalex.org/W2087124372","https://openalex.org/W2160731263","https://openalex.org/W2285980872","https://openalex.org/W2482032947","https://openalex.org/W2503800206","https://openalex.org/W2904214728"],"related_works":["https://openalex.org/W2053577828","https://openalex.org/W1967203266","https://openalex.org/W2061374630","https://openalex.org/W2038794389","https://openalex.org/W1979982507","https://openalex.org/W2087124372","https://openalex.org/W2374884357","https://openalex.org/W1979221503","https://openalex.org/W1994200338","https://openalex.org/W2955481248"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}