{"id":"https://openalex.org/W2043968848","doi":"https://doi.org/10.1016/0014-2999(84)90284-x","title":"Mechanism(s) of the hypotensive effect of synthetic 1-O-octadecyl-2-O-acetyl-glycero-3-phosphorylcholine","display_name":"Mechanism(s) of the hypotensive effect of synthetic 1-O-octadecyl-2-O-acetyl-glycero-3-phosphorylcholine","publication_year":1984,"publication_date":"1984-03-01","ids":{"openalex":"https://openalex.org/W2043968848","doi":"https://doi.org/10.1016/0014-2999(84)90284-x","mag":"2043968848","pmid":"https://pubmed.ncbi.nlm.nih.gov/6144557"},"language":"en","primary_location":{"id":"doi:10.1016/0014-2999(84)90284-x","doi":"https://doi.org/10.1016/0014-2999(84)90284-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2999(84)90284-x","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103937066","display_name":"Toshiharu Kamitani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Toshiharu Kamitani","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066552294","display_name":"Michiyo Katamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michiyo Katamoto","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mitsuyoshi Tatsumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuyoshi Tatsumi","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018059342","display_name":"Kiyotaka Katsuta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiyotaka Katsuta","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780584","display_name":"Takaharu Ono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takaharu Ono","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056880788","display_name":"Hiroyuki Kikuchi","orcid":"https://orcid.org/0000-0003-0510-1030","observed_orcids":["https://orcid.org/0000-0003-0510-1030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Kikuchi","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016078528","display_name":"Shigenobu Kumada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigenobu Kumada","raw_affiliation_strings":["Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Yodogawa-ku, Osaka 532, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103937066"],"corresponding_institution_ids":[],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":4.0509,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94056707,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"3-4","first_page":"357","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.18369999527931213,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.7720000147819519},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/renin-inhibitors","display_name":"renin inhibitors","score":0.6370000243186951},{"id":"https://openalex.org/keywords/doca-induced-hypertension","display_name":"DOCA-induced hypertension","score":0.6430000066757202},{"id":"https://openalex.org/keywords/pithed-rat","display_name":"pithed rat","score":0.675000011920929},{"id":"https://openalex.org/keywords/noradrenaline-pressor-response","display_name":"noradrenaline pressor response","score":0.8109999895095825},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9380000233650208},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/positive-inotropic-effect","display_name":"positive inotropic effect","score":0.8140000104904175},{"id":"https://openalex.org/keywords/phosphatidylcholine-analog","display_name":"phosphatidylcholine analog","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6396487951278687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6068934798240662},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5917695164680481},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.567402720451355},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5501782894134521},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5482485890388489},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.49977564811706543},{"id":"https://openalex.org/C2776833585","wikidata":"https://www.wikidata.org/wiki/Q7187582","display_name":"Phosphorylcholine","level":2,"score":0.4846370816230774},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4811888337135315},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.4637499451637268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4621238708496094},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.437019944190979},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.42147111892700195},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4149743318557739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32043200731277466},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07683134078979492},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003655","descriptor_name":"Decerebrate State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016275","descriptor_name":"Atrial Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-2999(84)90284-x","doi":"https://doi.org/10.1016/0014-2999(84)90284-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2999(84)90284-x","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:6144557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6144557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1893528652","https://openalex.org/W1927253437","https://openalex.org/W1963601281","https://openalex.org/W1972399329","https://openalex.org/W1976345463","https://openalex.org/W1978178959","https://openalex.org/W1978977859","https://openalex.org/W1988811896","https://openalex.org/W1991327356","https://openalex.org/W2018601554","https://openalex.org/W2022668542","https://openalex.org/W2030522109","https://openalex.org/W2059619922","https://openalex.org/W2061382578","https://openalex.org/W2063703111","https://openalex.org/W2067225278","https://openalex.org/W2068572428","https://openalex.org/W2076170575","https://openalex.org/W2099534187","https://openalex.org/W2134674910","https://openalex.org/W2146411543","https://openalex.org/W2166376385","https://openalex.org/W2402768053","https://openalex.org/W2434819415","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2094526532","https://openalex.org/W1978471655","https://openalex.org/W1963601281","https://openalex.org/W1972399329","https://openalex.org/W2408919469","https://openalex.org/W2012552353","https://openalex.org/W2297959303","https://openalex.org/W2061382578","https://openalex.org/W2188983073","https://openalex.org/W2033794533"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}