{"id":"https://openalex.org/W2043966868","doi":"https://doi.org/10.1002/ana.410260215","title":"Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome","display_name":"Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2043966868","doi":"https://doi.org/10.1002/ana.410260215","mag":"2043966868","pmid":"https://pubmed.ncbi.nlm.nih.gov/2528321"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410260215","doi":"https://doi.org/10.1002/ana.410260215","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410260215","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083815377","display_name":"Melvyn P. Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melvyn P. Hayes","raw_affiliation_strings":["Laboratory of Neurophysiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD","Section on Analytical Biochemistry, Laboratory of Clinical Science, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurophysiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Section on Analytical Biochemistry, Laboratory of Clinical Science, Bethesda, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000280765","display_name":"David R. Rubinow","orcid":"https://orcid.org/0000-0003-0815-2263","observed_orcids":["https://orcid.org/0000-0003-0815-2263"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rubinow","raw_affiliation_strings":["Biological Psychiatgry Branch, National Institute of Mental Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Psychiatgry Branch, National Institute of Mental Health, Bethesda, MD","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110094609","display_name":"Clifford Lane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford Lane","raw_affiliation_strings":["Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD","institution_ids":["https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111562890","display_name":"Sanford P. Markey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanford P. Markey","raw_affiliation_strings":["Section on Analytical Biochemistry, Laboratory of Clinical Science, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Analytical Biochemistry, Laboratory of Clinical Science, Bethesda, MD","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083815377"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":3.8652,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.93461538,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"2","first_page":"275","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinolinic-acid","display_name":"quinolinic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.828000009059906},{"id":"https://openalex.org/keywords/hiv-associated-dementia","display_name":"HIV-associated dementia","score":0.8080000281333923},{"id":"https://openalex.org/keywords/brain-atrophy","display_name":"brain atrophy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neurotoxins","display_name":"neurotoxins","score":0.8569999933242798},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2777896816","wikidata":"https://www.wikidata.org/wiki/Q411945","display_name":"Quinolinic acid","level":4,"score":0.9134210348129272},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8350971341133118},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5916981101036072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49732235074043274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4624405801296234},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28167957067489624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22490963339805603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10055378079414368},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.06299141049385071},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D011805","descriptor_name":"Quinolinic Acids","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017378","descriptor_name":"Quinolinic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410260215","doi":"https://doi.org/10.1002/ana.410260215","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410260215","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:2528321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2528321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1605075022","https://openalex.org/W1971946958","https://openalex.org/W1974060304","https://openalex.org/W1983414504","https://openalex.org/W2000248133","https://openalex.org/W2014660024","https://openalex.org/W2026332699","https://openalex.org/W2030692398","https://openalex.org/W2042043007","https://openalex.org/W2051353156","https://openalex.org/W2053124968","https://openalex.org/W2055623573","https://openalex.org/W2072450578","https://openalex.org/W2134970117","https://openalex.org/W2137343499","https://openalex.org/W2169211575","https://openalex.org/W2185557506"],"related_works":["https://openalex.org/W2018073475","https://openalex.org/W1995202463","https://openalex.org/W2001819303","https://openalex.org/W2084990956","https://openalex.org/W2123853156","https://openalex.org/W2042965601","https://openalex.org/W2000762235","https://openalex.org/W2018987864","https://openalex.org/W1602495434","https://openalex.org/W1975904624"],"abstract_inverted_index":{"Dementia":[0],"and":[1,47],"brain":[2,83],"atrophy":[3,25],"are":[4,87],"established":[5],"features":[6],"of":[7,11,32,42,92,95],"a":[8,21],"large":[9],"proportion":[10],"patients":[12,44],"with":[13,45],"acquired":[14],"immune":[15],"deficiency":[16],"syndrome":[17],"(AIDS).":[18],"To":[19],"investigate":[20],"potential":[22],"mechanism":[23],"for":[24],"in":[26,38,89],"AIDS,":[27],"we":[28],"measured":[29],"the":[30,33,39,90,93],"concentration":[31],"endogenous":[34],"neurotoxin":[35],"quinolinic":[36,54,84],"acid":[37,55,85],"cerebrospinal":[40],"fluid":[41],"10":[43],"AIDS":[46],"found":[48],"that":[49],"they":[50],"had":[51],"3-fold":[52],"higher":[53],"concentrations":[56,86],"than":[57,74],"9":[58],"age-matched":[59],"control":[60],"subjects:":[61],"53.8":[62],"+/-":[63,68],"10.7":[64],"pmol/ml":[65],"versus":[66],"18.4":[67],"3.4":[69],"pmol/ml,":[70],"respectively":[71],"(p":[72],"less":[73],"0.005).":[75],"It":[76],"remains":[77],"to":[78],"be":[79],"determined":[80],"whether":[81],"increased":[82],"involved":[88],"pathogenesis":[91],"neuropathology":[94],"AIDS.":[96]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
