{"id":"https://openalex.org/W2043957435","doi":"https://doi.org/10.1016/j.molcel.2005.05.022","title":"Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation","display_name":"Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2043957435","doi":"https://doi.org/10.1016/j.molcel.2005.05.022","mag":"2043957435","pmid":"https://pubmed.ncbi.nlm.nih.gov/15989971"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2005.05.022","doi":"https://doi.org/10.1016/j.molcel.2005.05.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2005.05.022","pdf_url":"http://www.cell.com/article/S1097276505013468/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1097276505013468/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006031220","display_name":"Ingo H. Gorr","orcid":"https://orcid.org/0000-0003-0046-6452","observed_orcids":["https://orcid.org/0000-0003-0046-6452"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo H. Gorr","raw_affiliation_strings":["Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany","Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012706479","display_name":"Dominik Boos","orcid":"https://orcid.org/0000-0003-0018-4375","observed_orcids":["https://orcid.org/0000-0003-0018-4375"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Boos","raw_affiliation_strings":["Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019334692","display_name":"Olaf Stemmann","orcid":"https://orcid.org/0000-0003-3044-2515","observed_orcids":["https://orcid.org/0000-0003-3044-2515"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Olaf Stemmann","raw_affiliation_strings":["Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany","Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019334692"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":4.9449,"has_fulltext":false,"cited_by_count":207,"citation_normalized_percentile":{"value":0.95720462,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"135","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/separase","display_name":"separase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/securin","display_name":"securin","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/anaphase-onset","display_name":"anaphase onset","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cohesin-cleavage","display_name":"cohesin cleavage","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sister-chromatid-separation","display_name":"sister chromatid separation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/protein-protein-complex-formation","display_name":"protein-protein complex formation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/protease-inhibition","display_name":"protease inhibition","score":0.7770000100135803},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.375}],"concepts":[{"id":"https://openalex.org/C136322937","wikidata":"https://www.wikidata.org/wiki/Q22676914","display_name":"Separase","level":5,"score":0.9984801411628723},{"id":"https://openalex.org/C63378162","wikidata":"https://www.wikidata.org/wiki/Q6740686","display_name":"Securin","level":5,"score":0.9504367113113403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6855595707893372},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.6621963977813721},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6467275619506836},{"id":"https://openalex.org/C53420372","wikidata":"https://www.wikidata.org/wiki/Q22299157","display_name":"Anaphase","level":4,"score":0.5695770382881165},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.4369284510612488},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23690050840377808},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.10972273349761963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08430373668670654}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064247","descriptor_name":"Separase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.molcel.2005.05.022","doi":"https://doi.org/10.1016/j.molcel.2005.05.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2005.05.022","pdf_url":"http://www.cell.com/article/S1097276505013468/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"pmid:15989971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15989971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Comparative Study"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00119312","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/15989971","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:261732","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/261732","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cell, v.19, 135-141 (2005)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2005.05.022","doi":"https://doi.org/10.1016/j.molcel.2005.05.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2005.05.022","pdf_url":"http://www.cell.com/article/S1097276505013468/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2043957435.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1983412918","https://openalex.org/W1986822039","https://openalex.org/W1999360313","https://openalex.org/W2004598829","https://openalex.org/W2005411204","https://openalex.org/W2006390282","https://openalex.org/W2016846235","https://openalex.org/W2027307439","https://openalex.org/W2031768526","https://openalex.org/W2039691661","https://openalex.org/W2063450668","https://openalex.org/W2091547495","https://openalex.org/W2105026768","https://openalex.org/W2116045064","https://openalex.org/W2132102069","https://openalex.org/W2132531571","https://openalex.org/W2142790777","https://openalex.org/W2158064045","https://openalex.org/W3029303231","https://openalex.org/W4230713695"],"related_works":["https://openalex.org/W2065600276","https://openalex.org/W3183755809","https://openalex.org/W1986164938","https://openalex.org/W2036607675","https://openalex.org/W3202982989","https://openalex.org/W1968304924","https://openalex.org/W2001507329","https://openalex.org/W2791023274","https://openalex.org/W4230713695","https://openalex.org/W4368356688"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}