{"id":"https://openalex.org/W2043957332","doi":"https://doi.org/10.1002/sim.3981","title":"Planning and analysis of cross\u2010over trials in infertility","display_name":"Planning and analysis of cross\u2010over trials in infertility","publication_year":2010,"publication_date":"2010-12-16","ids":{"openalex":"https://openalex.org/W2043957332","doi":"https://doi.org/10.1002/sim.3981","mag":"2043957332","pmid":"https://pubmed.ncbi.nlm.nih.gov/21170914"},"language":"en","primary_location":{"id":"doi:10.1002/sim.3981","doi":"https://doi.org/10.1002/sim.3981","is_oa":false,"landing_page_url":"https://doi.org/10.1002/sim.3981","pdf_url":null,"source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062802919","display_name":"Boikanyo Makubate","orcid":"https://orcid.org/0000-0002-1581-3165","observed_orcids":["https://orcid.org/0000-0002-1581-3165"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Boikanyo Makubate","raw_affiliation_strings":["College of Medicine, Dentistry and Nursing, University of Dundee DD2 4BF, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Dentistry and Nursing, University of Dundee DD2 4BF, U.K","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006700282","display_name":"Stephen John Senn","orcid":"https://orcid.org/0000-0002-7558-8473","observed_orcids":["https://orcid.org/0000-0002-7558-8473"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen Senn","raw_affiliation_strings":["Department of Statistics, University of Glasgow, Glasgow G12 9LL, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Glasgow, Glasgow G12 9LL, U.K","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006700282"],"corresponding_institution_ids":["https://openalex.org/I7882870"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.6954,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71489046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"30","first_page":"3203","last_page":"3210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crossover-trial","display_name":"crossover trial","score":0.9769999980926514},{"id":"https://openalex.org/keywords/infertility-treatment","display_name":"infertility treatment","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mantel-haenszel-test","display_name":"Mantel-Haenszel procedure","score":0.968999981880188},{"id":"https://openalex.org/keywords/trial-design-comparison","display_name":"trial design comparison","score":0.5839999914169312},{"id":"https://openalex.org/keywords/simulation-study","display_name":"simulation study","score":0.5370000004768372},{"id":"https://openalex.org/keywords/statistical-analysis-of-clinical-trials","display_name":"statistical analysis of clinical trials","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.7490047216415405},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6409971714019775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.54094398021698},{"id":"https://openalex.org/C41054675","wikidata":"https://www.wikidata.org/wiki/Q185547","display_name":"Binomial distribution","level":2,"score":0.5312647223472595},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.4459889829158783},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.35372158885002136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33507925271987915},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22069832682609558},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1671231985092163},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1159113347530365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06353038549423218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003075","descriptor_name":"Coitus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007315","descriptor_name":"Insemination, Artificial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010062","descriptor_name":"Ovulation Induction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/sim.3981","doi":"https://doi.org/10.1002/sim.3981","is_oa":false,"landing_page_url":"https://doi.org/10.1002/sim.3981","pdf_url":null,"source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},{"id":"pmid:21170914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21170914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:eprints.gla.ac.uk:47891","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/47891/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W987144911","https://openalex.org/W1135625598","https://openalex.org/W1968699244","https://openalex.org/W1976290551","https://openalex.org/W1991424745","https://openalex.org/W2010376111","https://openalex.org/W2010379916","https://openalex.org/W2093844289","https://openalex.org/W2102100691","https://openalex.org/W2128747706","https://openalex.org/W2129440717","https://openalex.org/W2150000105","https://openalex.org/W2152527116","https://openalex.org/W2168193552","https://openalex.org/W2170001615","https://openalex.org/W2269974365","https://openalex.org/W2479929249","https://openalex.org/W4229753260","https://openalex.org/W4251550306"],"related_works":["https://openalex.org/W2062191152","https://openalex.org/W2128747706","https://openalex.org/W62078659","https://openalex.org/W2143379509","https://openalex.org/W2161318994","https://openalex.org/W2093844289","https://openalex.org/W2171971147","https://openalex.org/W2049996584","https://openalex.org/W2088034653","https://openalex.org/W2093793200"],"abstract_inverted_index":{"The":[0],"use":[1,107],"of":[2,36,61],"cross-over":[3,85,101],"trials":[4,19,62,86,94,102],"in":[5,50,63,87],"investigating":[6],"treatments":[7],"for":[8],"infertility":[9,88],"is":[10,24,40,43,76,80],"discussed.":[11],"A":[12,26],"simple":[13],"possible":[14],"approach":[15,29,66],"to":[16,57,71],"analyzing":[17],"such":[18],"using":[20],"the":[21,32],"Mantel-Haenszel":[22],"procedure":[23],"explained.":[25],"more":[27,110],"flexible":[28],"based":[30],"on":[31],"normal-binomial":[33],"mixture":[34],"model":[35],"Ezzet":[37],"and":[38],"Whitehead":[39],"examined.":[41],"It":[42,79],"shown":[44],"how":[45],"this":[46],"may":[47,68,108],"be":[48,69,109],"implemented":[49],"various":[51],"statistical":[52],"packages":[53],"by":[54],"applying":[55],"it":[56],"two":[58],"real":[59],"examples":[60],"infertility.":[64],"An":[65],"that":[67,82,84,113],"used":[70],"compare":[72],"designs":[73],"via":[74],"simulation":[75],"explained":[77],"briefly.":[78],"concluded":[81],"provided":[83],"are":[89],"regarded":[90],"as":[91,100],"parallel":[92],"group":[93],"with":[95,103],"extra":[96],"information":[97],"rather":[98],"than":[99,112],"missing":[104],"information,":[105],"their":[106],"promising":[111],"has":[114],"previously":[115],"been":[116],"concluded.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}