{"id":"https://openalex.org/W2043955249","doi":"https://doi.org/10.1161/strokeaha.114.007489","title":"Fibroblast Growth Factor 23 and Risk of Incident Stroke in Community-Living Adults","display_name":"Fibroblast Growth Factor 23 and Risk of Incident Stroke in Community-Living Adults","publication_year":2015,"publication_date":"2015-01-07","ids":{"openalex":"https://openalex.org/W2043955249","doi":"https://doi.org/10.1161/strokeaha.114.007489","mag":"2043955249","pmid":"https://pubmed.ncbi.nlm.nih.gov/25563643","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308535"},"language":"en","primary_location":{"id":"doi:10.1161/strokeaha.114.007489","doi":"https://doi.org/10.1161/strokeaha.114.007489","is_oa":false,"landing_page_url":"https://doi.org/10.1161/strokeaha.114.007489","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308535","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009398299","display_name":"Bhupesh Panwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhupesh Panwar","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017302499","display_name":"Nancy S. Jenny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy S. Jenny","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082076462","display_name":"Virginia J. Howard","orcid":"https://orcid.org/0000-0003-4912-9975","observed_orcids":["https://orcid.org/0000-0003-4912-9975"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia J. Howard","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084454712","display_name":"Virginia G. Wadley","orcid":"https://orcid.org/0000-0003-4524-8395","observed_orcids":["https://orcid.org/0000-0003-4524-8395"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia G. Wadley","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079959622","display_name":"Paul Muntner","orcid":"https://orcid.org/0000-0002-4711-5492","observed_orcids":["https://orcid.org/0000-0002-4711-5492"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Muntner","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075585875","display_name":"Brett M. Kissela M. D","orcid":"https://orcid.org/0000-0002-9773-4013","observed_orcids":["https://orcid.org/0000-0002-9773-4013","https://orcid.org/0000-0002-4839-3814"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett M. Kissela","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076115498","display_name":"Suzanne E. Judd","orcid":"https://orcid.org/0000-0001-7594-6587","observed_orcids":["https://orcid.org/0000-0001-7594-6587"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne E. Judd","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Pathology, University of Vermont, Burlington (N.S.J.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pathology, University of Vermont, Burlington (N.S.J.)","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041495874","display_name":"Orlando M. Guti\u00e9rrez","orcid":"https://orcid.org/0000-0001-6593-3571","observed_orcids":["https://orcid.org/0000-0001-6593-3571"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orlando M. Guti\u00e9rrez","raw_affiliation_strings":["From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","Department of Neurology, University of Cincinnati, OH (B.M.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I32389192","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Neurology, University of Cincinnati, OH (B.M.K.)","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.4919,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.97330035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"46","issue":"2","first_page":"322","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9990000128746033},{"id":"https://openalex.org/keywords/incident-stroke","display_name":"incident stroke","score":0.859000027179718},{"id":"https://openalex.org/keywords/cardioembolic-stroke","display_name":"cardioembolic stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/ischemic-stroke-subtypes","display_name":"ischemic stroke subtypes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hemorrhagic-stroke","display_name":"hemorrhagic stroke","score":0.9120000004768372},{"id":"https://openalex.org/keywords/phosphorus-metabolism","display_name":"phosphorus metabolism","score":0.6119999885559082},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.8980000019073486},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.5109999775886536},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/urinary-albumin-excretion","display_name":"urinary albumin excretion","score":0.847000002861023},{"id":"https://openalex.org/keywords/regards-study","display_name":"REGARDS study","score":0.7639999985694885},{"id":"https://openalex.org/keywords/community-dwelling-adults","display_name":"community-dwelling adults","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.89638352394104},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.8203338384628296},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.7457104921340942},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7387480735778809},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.687207043170929},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.6628382205963135},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6105838418006897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5814987421035767},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.504473090171814},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5042604207992554},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4499720335006714},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.06842514872550964},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011159","descriptor_name":"Population Surveillance","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/strokeaha.114.007489","doi":"https://doi.org/10.1161/strokeaha.114.007489","is_oa":false,"landing_page_url":"https://doi.org/10.1161/strokeaha.114.007489","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:25563643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25563643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4308535","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stroke","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4308535","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4308535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stroke","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1429240514","display_name":"VCID and Stroke in a Bi-racial National Cohort","funder_award_id":"U01NS041588","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5264540014","display_name":"Center for Clinical and Translational Science and Training","funder_award_id":"UL1TR001425","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6763906084","display_name":"Etiology of Geographic and Racial Differences in Stroke","funder_award_id":"R01NS041588","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7936262925","display_name":"Impact of disordered mineral metabolism on stroke and cognitive impairment","funder_award_id":"R01NS080850","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8119036761","display_name":"Phosphorus-based Food Additives, Mineral Metabolism and Cardiovascular Health","funder_award_id":"R03DK095005","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8701320340","display_name":"Cincinnati Center for Clinical and Translational Sciences and Training","funder_award_id":"UL1TR000077","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1803609188","https://openalex.org/W1971658255","https://openalex.org/W1972317569","https://openalex.org/W1977645780","https://openalex.org/W1979020186","https://openalex.org/W2004659889","https://openalex.org/W2010377220","https://openalex.org/W2015668150","https://openalex.org/W2018549325","https://openalex.org/W2019243843","https://openalex.org/W2030506909","https://openalex.org/W2034578148","https://openalex.org/W2047925859","https://openalex.org/W2051186854","https://openalex.org/W2067395123","https://openalex.org/W2078382957","https://openalex.org/W2079331899","https://openalex.org/W2082108703","https://openalex.org/W2086951936","https://openalex.org/W2100168006","https://openalex.org/W2107420262","https://openalex.org/W2111614075","https://openalex.org/W2113697904","https://openalex.org/W2114238925","https://openalex.org/W2125079553","https://openalex.org/W2125383113","https://openalex.org/W2131843552","https://openalex.org/W2138595885","https://openalex.org/W2140575711","https://openalex.org/W2152330606","https://openalex.org/W2155965977","https://openalex.org/W2157448600","https://openalex.org/W2168111494","https://openalex.org/W2170815984","https://openalex.org/W2475261460","https://openalex.org/W2527550773","https://openalex.org/W2560549015","https://openalex.org/W2607031541"],"related_works":["https://openalex.org/W1560362580","https://openalex.org/W2272644681","https://openalex.org/W2082108703","https://openalex.org/W2887346571","https://openalex.org/W2171947017","https://openalex.org/W4392097533","https://openalex.org/W1993784854","https://openalex.org/W3113645429","https://openalex.org/W2033576591","https://openalex.org/W4405394270"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Fibroblast":[3],"growth":[4],"factor":[5],"23":[6],"(FGF23)":[7],"is":[8],"a":[9,40,68,172],"hormone":[10],"that":[11],"regulates":[12],"phosphorus":[13,108],"and":[14,61,72,89,107,115,146],"vitamin":[15],"D":[16],"metabolism.":[17],"Elevated":[18],"FGF23":[19,31,51,78,133,176,223,235],"concentrations":[20,52,236],"are":[21,35],"associated":[22,122,238],"with":[23,32,53,123,134,155,177,224,230,239,246],"excess":[24],"risk":[25,135,149,178,241],"of":[26,30,48,70,132,136,175,179,222,242],"cardiovascular":[27],"disease.":[28],"Associations":[29],"stroke":[33,55,87,138,148,168,181,227,248],"outcomes":[34],"less":[36],"clear.":[37],"METHODS:":[38],"Using":[39],"case-cohort":[41],"study":[42],"design,":[43],"we":[44],"examined":[45],"the":[46,57,96],"association":[47,131,174],"baseline":[49],"plasma":[50],"incident":[54,86],"in":[56,64,81,90,139,182,250],"Reasons":[58],"for":[59,143,258],"Geographic":[60],"Racial":[62],"Differences":[63],"Stroke":[65],"(REGARDS)":[66],"study,":[67],"cohort":[69,98],"black":[71],"white":[73],"adults":[74],"aged":[75],"\u226545":[76],"years.":[77],"was":[79,127,171],"measured":[80],"615":[82],"participants":[83,92],"who":[84],"developed":[85],"(cases)":[88],"936":[91],"randomly":[93],"selected":[94],"from":[95],"REGARDS":[97],"(comparison":[99],"subcohort).":[100],"RESULTS:":[101],"In":[102,163],"multivariable-adjusted":[103],"models,":[104],"higher":[105,116,124,240],"calcium":[106],"concentrations,":[109],"lower":[110],"estimated":[111],"glomerular":[112],"filtration":[113],"rate":[114],"urine":[117],"albumin":[118],"excretion":[119],"were":[120,217,237],"independently":[121],"FGF23.":[125],"There":[126,216],"no":[128,218],"statistically":[129,219],"significant":[130,220],"all-cause":[137],"Cox":[140],"models":[141,165,185],"adjusted":[142,184],"demographic":[144],"factors":[145,150],"established":[147],"(hazard":[151],"ratio":[152],"comparing":[153],"fourth":[154],"first":[156],"quartile":[157,189,198,207],"1.19;":[158],"95%":[159,194,203,212],"confidence":[160,195,204,213],"interval,":[161,196,205,214],"0.78-1.82).":[162],"prespecified":[164],"stratified":[166],"by":[167],"subtypes,":[169],"there":[170],"graded":[173],"cardioembolic":[180,243],"fully":[183],"(quartile":[186],"1,":[187],"reference;":[188],"2":[190],"hazard":[191,200,209],"ratio,":[192,201,210],"1.48;":[193],"0.63-3.47;":[197],"3":[199],"1.99;":[202],"0.89-4.44;":[206],"4":[208],"2.52;":[211],"1.08-5.91).":[215],"associations":[221],"other":[225,247],"ischemic":[226],"subtypes":[228,249],"or":[229],"hemorrhagic":[231],"strokes.":[232],"CONCLUSIONS:":[233],"Higher":[234],"but":[244],"not":[245],"community-dwelling":[251],"adults.":[252],"Additional":[253],"studies":[254],"should":[255],"delineate":[256],"reasons":[257],"these":[259],"findings.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
