{"id":"https://openalex.org/W2043946174","doi":"https://doi.org/10.1016/j.cytogfr.2013.05.004","title":"The role of IL-15 in gastrointestinal diseases: A bridge between innate and adaptive immune response","display_name":"The role of IL-15 in gastrointestinal diseases: A bridge between innate and adaptive immune response","publication_year":2013,"publication_date":"2013-06-21","ids":{"openalex":"https://openalex.org/W2043946174","doi":"https://doi.org/10.1016/j.cytogfr.2013.05.004","mag":"2043946174","pmid":"https://pubmed.ncbi.nlm.nih.gov/23791986"},"language":"en","primary_location":{"id":"doi:10.1016/j.cytogfr.2013.05.004","doi":"https://doi.org/10.1016/j.cytogfr.2013.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cytogfr.2013.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S194552188","display_name":"Cytokine & Growth Factor Reviews","issn_l":"1359-6101","issn":["1359-6101","1879-0305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine &amp; Growth Factor Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046180812","display_name":"Danilo Pagliari","orcid":"https://orcid.org/0000-0003-1235-2276","observed_orcids":["https://orcid.org/0000-0003-1235-2276"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Danilo Pagliari","raw_affiliation_strings":["Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072093447","display_name":"Rossella Cianci","orcid":"https://orcid.org/0000-0001-5378-8442","observed_orcids":["https://orcid.org/0000-0001-5378-8442"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Cianci","raw_affiliation_strings":["Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047017647","display_name":"Simona Frosali","orcid":"https://orcid.org/0000-0002-8026-0675","observed_orcids":["https://orcid.org/0000-0002-8026-0675"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Frosali","raw_affiliation_strings":["Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059461810","display_name":"Raffaele Landolfi","orcid":"https://orcid.org/0000-0002-7913-8576","observed_orcids":["https://orcid.org/0000-0002-7913-8576"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Landolfi","raw_affiliation_strings":["Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085399427","display_name":"Giovanni Cammarota","orcid":"https://orcid.org/0000-0002-3626-6148","observed_orcids":["https://orcid.org/0000-0002-3626-6148"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Cammarota","raw_affiliation_strings":["Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078554490","display_name":"Estelle E. Newton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111023","display_name":"CytoCure (United States)","ror":"https://ror.org/026prsd04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111023"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Estelle E. Newton","raw_affiliation_strings":["CytoCure LLC, Beverly, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CytoCure LLC, Beverly, MA, USA","institution_ids":["https://openalex.org/I4210111023"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106571602","display_name":"Franco Pandolfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Franco Pandolfi","raw_affiliation_strings":["Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5106571602"],"corresponding_institution_ids":["https://openalex.org/I103320735"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":1.0762,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.70810313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"24","issue":"5","first_page":"455","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.16040000319480896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.9750000238418579},{"id":"https://openalex.org/keywords/il-15-receptor","display_name":"IL-15 receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.6819999814033508},{"id":"https://openalex.org/keywords/intestinal-homeostasis","display_name":"intestinal homeostasis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":1.0},{"id":"https://openalex.org/keywords/innate-and-adaptive-immunity","display_name":"innate and adaptive immunity","score":0.6389999985694885},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.768164873123169},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.6847671270370483},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5940635800361633},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.5704255104064941},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.5617562532424927},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.5610781311988831},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5223509073257446},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4235905110836029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38119256496429443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08645156025886536}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002446","descriptor_name":"Celiac Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002446","descriptor_name":"Celiac Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019409","descriptor_name":"Interleukin-15","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053647","descriptor_name":"Receptors, Interleukin-15","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cytogfr.2013.05.004","doi":"https://doi.org/10.1016/j.cytogfr.2013.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cytogfr.2013.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S194552188","display_name":"Cytokine & Growth Factor Reviews","issn_l":"1359-6101","issn":["1359-6101","1879-0305"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine &amp; Growth Factor Reviews","raw_type":"journal-article"},{"id":"pmid:23791986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23791986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine & growth factor reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W134677238","https://openalex.org/W210616668","https://openalex.org/W278617097","https://openalex.org/W349771030","https://openalex.org/W1487210663","https://openalex.org/W1504114827","https://openalex.org/W1504841734","https://openalex.org/W1535243328","https://openalex.org/W1539591812","https://openalex.org/W1551599923","https://openalex.org/W1564622887","https://openalex.org/W1570245632","https://openalex.org/W1605568018","https://openalex.org/W1631804487","https://openalex.org/W1642448589","https://openalex.org/W1653117510","https://openalex.org/W1787550163","https://openalex.org/W1829424702","https://openalex.org/W1832052391","https://openalex.org/W1834807331","https://openalex.org/W1879871130","https://openalex.org/W1891734594","https://openalex.org/W1931387024","https://openalex.org/W1946093640","https://openalex.org/W1956135695","https://openalex.org/W1963861776","https://openalex.org/W1965590674","https://openalex.org/W1968321644","https://openalex.org/W1970080316","https://openalex.org/W1970563382","https://openalex.org/W1972810072","https://openalex.org/W1977306840","https://openalex.org/W1978176752","https://openalex.org/W1979122524","https://openalex.org/W1984849109","https://openalex.org/W1985673014","https://openalex.org/W1988008906","https://openalex.org/W1988881559","https://openalex.org/W1989613591","https://openalex.org/W1991473719","https://openalex.org/W1992279591","https://openalex.org/W1994808474","https://openalex.org/W2001677047","https://openalex.org/W2004068338","https://openalex.org/W2007490062","https://openalex.org/W2008732348","https://openalex.org/W2009316592","https://openalex.org/W2011992917","https://openalex.org/W2013928717","https://openalex.org/W2024225734","https://openalex.org/W2033367896","https://openalex.org/W2033969684","https://openalex.org/W2035118608","https://openalex.org/W2037070751","https://openalex.org/W2038586201","https://openalex.org/W2042578023","https://openalex.org/W2045762926","https://openalex.org/W2047102094","https://openalex.org/W2054458496","https://openalex.org/W2057331818","https://openalex.org/W2058779450","https://openalex.org/W2059412913","https://openalex.org/W2059426479","https://openalex.org/W2059542392","https://openalex.org/W2059761425","https://openalex.org/W2061840611","https://openalex.org/W2068234766","https://openalex.org/W2069423665","https://openalex.org/W2069558108","https://openalex.org/W2076010157","https://openalex.org/W2078508483","https://openalex.org/W2078710292","https://openalex.org/W2079577154","https://openalex.org/W2079683856","https://openalex.org/W2080480755","https://openalex.org/W2081078967","https://openalex.org/W2084105573","https://openalex.org/W2084159240","https://openalex.org/W2084599508","https://openalex.org/W2086217304","https://openalex.org/W2092555075","https://openalex.org/W2095138364","https://openalex.org/W2095404856","https://openalex.org/W2095433065","https://openalex.org/W2097400398","https://openalex.org/W2097892467","https://openalex.org/W2099601900","https://openalex.org/W2102288448","https://openalex.org/W2110846887","https://openalex.org/W2111829151","https://openalex.org/W2111945592","https://openalex.org/W2114408584","https://openalex.org/W2114530568","https://openalex.org/W2115348669","https://openalex.org/W2116731111","https://openalex.org/W2119080021","https://openalex.org/W2119546454","https://openalex.org/W2122939321","https://openalex.org/W2126078533","https://openalex.org/W2126182332","https://openalex.org/W2126355296","https://openalex.org/W2127402954","https://openalex.org/W2130898753","https://openalex.org/W2132226366","https://openalex.org/W2132285384","https://openalex.org/W2133029921","https://openalex.org/W2133644846","https://openalex.org/W2134470782","https://openalex.org/W2139056292","https://openalex.org/W2142285575","https://openalex.org/W2147436604","https://openalex.org/W2147543156","https://openalex.org/W2149897151","https://openalex.org/W2151272317","https://openalex.org/W2154740756","https://openalex.org/W2165428460","https://openalex.org/W2169044901","https://openalex.org/W2169770330","https://openalex.org/W2187830163","https://openalex.org/W2270208951","https://openalex.org/W2396201006","https://openalex.org/W4235912108","https://openalex.org/W6611693821","https://openalex.org/W6640654560","https://openalex.org/W6678574078","https://openalex.org/W6680014360","https://openalex.org/W6686521043","https://openalex.org/W6686596983","https://openalex.org/W6712300296"],"related_works":["https://openalex.org/W2318785030","https://openalex.org/W2033969684","https://openalex.org/W7201928182","https://openalex.org/W3084246765","https://openalex.org/W4391340073","https://openalex.org/W4415283750","https://openalex.org/W7028255765","https://openalex.org/W1993075572","https://openalex.org/W2078508483","https://openalex.org/W7117690188"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
