{"id":"https://openalex.org/W2043945323","doi":"https://doi.org/10.1111/j.1365-2141.1982.tb02780.x","title":"Busulphan aplasia in rabbits: a model for human aplastic anaemia","display_name":"Busulphan aplasia in rabbits: a model for human aplastic anaemia","publication_year":1982,"publication_date":"1982-06-01","ids":{"openalex":"https://openalex.org/W2043945323","doi":"https://doi.org/10.1111/j.1365-2141.1982.tb02780.x","mag":"2043945323","pmid":"https://pubmed.ncbi.nlm.nih.gov/7082585"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.1982.tb02780.x","doi":"https://doi.org/10.1111/j.1365-2141.1982.tb02780.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1982.tb02780.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109881795","display_name":"Gerard J. Den Ottolander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Gerard J. den Ottolander","raw_affiliation_strings":["Department of Haematology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800245","display_name":"J. te Velde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan te Velde","raw_affiliation_strings":["Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110082975","display_name":"Wil Veenhof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wil Veenhof","raw_affiliation_strings":["J. A. Cohen Institute for Radiopathology and Radiation Protection, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. A. Cohen Institute for Radiopathology and Radiation Protection, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108497080","display_name":"Karin Kleiverda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Karin Kleiverda","raw_affiliation_strings":["Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047459192","display_name":"Hans L. Haak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hans L. Haak","raw_affiliation_strings":["J. A. Cohen Institute for Radiopathology and Radiation Protection, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. A. Cohen Institute for Radiopathology and Radiation Protection, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012615420","display_name":"Piet Jan Spaander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Piet Jan Spaander","raw_affiliation_strings":["Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands","J. A. Cohen Institute for Radiopathology and Radiation Protection, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"J. A. Cohen Institute for Radiopathology and Radiation Protection, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109881795"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.3057,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.58708563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"51","issue":"2","first_page":"265","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.23319999873638153,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/busulfan","display_name":"busulfan","score":0.9070000052452087},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bone-marrow-histology","display_name":"bone marrow histology","score":0.8949999809265137},{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"granulopoiesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.906000018119812},{"id":"https://openalex.org/keywords/dyserythropoiesis","display_name":"dyserythropoiesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bone-marrow-fibrosis","display_name":"bone marrow fibrosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mean-corpuscular-volume","display_name":"mean corpuscular volume","score":0.8579999804496765},{"id":"https://openalex.org/keywords/stem-cell-defect","display_name":"stem cell defect","score":0.8240000009536743},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2778368355","wikidata":"https://www.wikidata.org/wiki/Q5488","display_name":"Aplasia","level":2,"score":0.7322959303855896},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.686482310295105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6544232368469238},{"id":"https://openalex.org/C2911114841","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Bone Marrow Aplasia","level":3,"score":0.5982546806335449},{"id":"https://openalex.org/C2775895862","wikidata":"https://www.wikidata.org/wiki/Q356405","display_name":"Bloodletting","level":3,"score":0.4436712861061096},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33837300539016724},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2746425271034241},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1648988127708435},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.11988481879234314},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004909","descriptor_name":"Erythrocyte Indices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010198","descriptor_name":"Pancytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2141.1982.tb02780.x","doi":"https://doi.org/10.1111/j.1365-2141.1982.tb02780.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1982.tb02780.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"doi:10.1111/j.1365-2141.1982.tb08484.x","doi":"https://doi.org/10.1111/j.1365-2141.1982.tb08484.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1982.tb08484.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:7082585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7082585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W43183315","https://openalex.org/W1990839168","https://openalex.org/W2042361996","https://openalex.org/W2043228542","https://openalex.org/W2046972260","https://openalex.org/W2048898405","https://openalex.org/W2054653558","https://openalex.org/W2083863239","https://openalex.org/W2140872897","https://openalex.org/W2148891141","https://openalex.org/W2161543971","https://openalex.org/W2201651856","https://openalex.org/W2259051286","https://openalex.org/W2396615601","https://openalex.org/W2400385801","https://openalex.org/W2401865969","https://openalex.org/W2418606075","https://openalex.org/W2431159622","https://openalex.org/W2463382164","https://openalex.org/W3111857462","https://openalex.org/W4229968966","https://openalex.org/W4247556390","https://openalex.org/W4250176799","https://openalex.org/W4253058882","https://openalex.org/W4255635114"],"related_works":["https://openalex.org/W1598447182","https://openalex.org/W1823902728","https://openalex.org/W2275017360","https://openalex.org/W3017804818","https://openalex.org/W43183315","https://openalex.org/W2302926567","https://openalex.org/W2562421604","https://openalex.org/W2471001396","https://openalex.org/W2372415419","https://openalex.org/W2007632705"],"abstract_inverted_index":{"Bone":[0],"marrow":[1,70],"histology":[2],"plays":[3],"a":[4,123,165,195],"crucial":[5],"role":[6],"in":[7,31,51,109,115,147,151,167,181,190],"the":[8,17,26,32,36,68,77,116,119,126,161,199],"clinical":[9],"diagnosis":[10],"of":[11,16,35,38,67,90,97,118,125,160,177,201],"aplastic":[12,202],"anaemia.":[13],"The":[14],"nature":[15],"disease":[18],"means":[19],"that":[20,107],"few":[21],"studies":[22],"are":[23],"available":[24],"on":[25],"histological":[27,65],"changes":[28],"which":[29,46,99,149,169,183],"occur":[30],"early":[33,85],"stages":[34],"development":[37],"aplasia.":[39,63,81],"We":[40],"describe":[41],"here":[42],"an":[43,84],"animal":[44],"model":[45,197],"may":[47],"have":[48],"some":[49],"relevance":[50],"this":[52],"respect.":[53],"Rabbits":[54],"were":[55],"chronically":[56],"exposed":[57],"to":[58,61,73,205],"busulphan":[59],"(BU)":[60],"induce":[62],"Sequential":[64],"monitoring":[66],"bone":[69],"was":[71,83,145,164,170],"performed":[72],"obtain":[74],"information":[75],"about":[76],"events":[78],"preceding":[79],"full-blown":[80],"There":[82],"decrease":[86,124],"and":[87,92,132,139],"ultimate":[88],"disappearance":[89],"granulo-":[91],"megakaryopoiesis":[93],"with":[94,122,153,173],"relative":[95],"sparing":[96],"erythropoiesis":[98],"showed":[100],"severe":[101],"displasia.":[102],"Increasing":[103],"lymphoplasmacytoid":[104],"infiltrate":[105],"resembling":[106],"seen":[108],"human":[110,154,188],"aplasia":[111,155,180,189],"could":[112],"be":[113,194],"observed":[114,146],"majority":[117],"animals,":[120],"together":[121],"peripheral":[127],"lymphocyte":[128,137],"number.":[129],"Lymph":[130],"nodes":[131],"spleen":[133],"did":[134],"not":[135,171],"show":[136],"depletion":[138],"serum":[140],"gamma-globulin":[141],"remained":[142],"stable.":[143],"Fibrosis":[144],"50%":[148],"is":[150],"contrast":[152],"at":[156],"diagnosis.":[157],"In":[158],"half":[159],"animals":[162],"there":[163],"rise":[166],"MCV,":[168],"correlated":[172],"reticulocytosis":[174],"or":[175],"degree":[176],"dyserythropoiesis.":[178],"BU-induced":[179],"rabbits,":[182],"resembles":[184],"long-standing":[185],"grade":[186],"II":[187],"many":[191],"respects,":[192],"might":[193],"suitable":[196],"for":[198],"study":[200],"anaemia":[203],"due":[204],"stem":[206],"cell":[207],"defects.":[208]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
