{"id":"https://openalex.org/W2043943442","doi":"https://doi.org/10.1111/j.1365-2222.2008.02969.x","title":"IL\u201013 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells","display_name":"IL\u201013 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2043943442","doi":"https://doi.org/10.1111/j.1365-2222.2008.02969.x","mag":"2043943442","pmid":"https://pubmed.ncbi.nlm.nih.gov/18384429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11934259"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2222.2008.02969.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.02969.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.02969.x","pdf_url":null,"source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Allergy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2043943442"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11934259/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039891994","display_name":"Kazuyuki Chibana","orcid":"https://orcid.org/0000-0001-7415-5097","observed_orcids":["https://orcid.org/0000-0001-7415-5097"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Chibana","raw_affiliation_strings":["Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. chibanak@upmc.edu","Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. chibanak@upmc.edu","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057676970","display_name":"John B. Trudeau","orcid":"https://orcid.org/0000-0002-0473-2730","observed_orcids":["https://orcid.org/0000-0002-0473-2730"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. B. Trudeau","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005337909","display_name":"Anthony T. Mustovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. T. Mustovitch","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Hu","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103137021","display_name":"Jennifer Zhao","orcid":"https://orcid.org/0009-0000-6829-8315","observed_orcids":["https://orcid.org/0009-0000-6829-8315"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zhao","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051340407","display_name":"Silvana Balzar","orcid":"https://orcid.org/0000-0001-6100-6359","observed_orcids":["https://orcid.org/0000-0001-6100-6359"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Balzar","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. W. Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. W. Chu","raw_affiliation_strings":["National Jewish Medical and Research Center and University of Colorado Health Science Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Medical and Research Center and University of Colorado Health Science Center, Denver, CO","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062793362","display_name":"Sally E. Wenzel","orcid":"https://orcid.org/0000-0002-4242-0164","observed_orcids":["https://orcid.org/0000-0002-4242-0164"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. E. Wenzel","raw_affiliation_strings":["Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center; Pittsburgh, PA","institution_ids":["https://openalex.org/I4210134769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039891994"],"corresponding_institution_ids":["https://openalex.org/I4210134769"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":4.8784,"has_fulltext":false,"cited_by_count":222,"citation_normalized_percentile":{"value":0.94720469,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"38","issue":"6","first_page":"936","last_page":"946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.949999988079071},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/arginase-2","display_name":"arginase II","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.7870000004768372},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.8399999737739563},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.9309999942779541},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/air-liquid-interface-culture","display_name":"air-liquid interface culture","score":0.9419999718666077},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.9670121669769287},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7771679162979126},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6489652991294861},{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.5672915577888489},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5170220136642456},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4884277880191803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43114161491394043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3860844373703003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3581897020339966},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35303884744644165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.331815242767334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33016785979270935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23334702849388123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2222858965396881},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08667221665382385},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.059789955615997314},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2222.2008.02969.x","doi":"https://doi.org/10.1111/j.1365-2222.2008.02969.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2222.2008.02969.x","pdf_url":null,"source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Allergy","raw_type":"journal-article"},{"id":"pmid:18384429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18384429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11934259","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11934259/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Exp Allergy","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11934259","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11934259/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Exp Allergy","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2229886327","display_name":"Amplification of IL-4Ralpha signaling pathways in human airways through 15 LO1","funder_award_id":"R01AI040600","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5664278136","display_name":"University of Pittsburgh Clinical and Translational Science Institute","funder_award_id":"UL1TR000005","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6965085950","display_name":"Th2 effects on eicosanoid pathways: implications for altered innate responses in","funder_award_id":"R01AI067780","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332530","display_name":"Medical Center, University of Pittsburgh","ror":"https://ror.org/04ehecz88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W37419188","https://openalex.org/W1497986985","https://openalex.org/W1586801024","https://openalex.org/W1835748585","https://openalex.org/W1945942263","https://openalex.org/W1956895244","https://openalex.org/W1967398861","https://openalex.org/W1969948192","https://openalex.org/W1974698157","https://openalex.org/W1977678789","https://openalex.org/W1990802251","https://openalex.org/W1993997407","https://openalex.org/W1996058483","https://openalex.org/W2004725730","https://openalex.org/W2011115843","https://openalex.org/W2028505614","https://openalex.org/W2033249210","https://openalex.org/W2038777547","https://openalex.org/W2038992843","https://openalex.org/W2041283753","https://openalex.org/W2041989261","https://openalex.org/W2053000339","https://openalex.org/W2058403295","https://openalex.org/W2061276553","https://openalex.org/W2064398657","https://openalex.org/W2072742024","https://openalex.org/W2087185866","https://openalex.org/W2089122893","https://openalex.org/W2093366237","https://openalex.org/W2097491679","https://openalex.org/W2107207387","https://openalex.org/W2129431737","https://openalex.org/W2148954084","https://openalex.org/W2150849592","https://openalex.org/W2159495030","https://openalex.org/W2163580173","https://openalex.org/W2165694323","https://openalex.org/W2169199920","https://openalex.org/W2170012044","https://openalex.org/W2414151952","https://openalex.org/W2419604885"],"related_works":["https://openalex.org/W2093366237","https://openalex.org/W2064398657","https://openalex.org/W1980462938","https://openalex.org/W2100204806","https://openalex.org/W9022119","https://openalex.org/W2144971186","https://openalex.org/W2045168516","https://openalex.org/W1586801024","https://openalex.org/W4232744455","https://openalex.org/W1497986985"],"abstract_inverted_index":{"BACKGROUND:":[0],"Exhaled":[1],"nitric":[2,39],"oxide":[3,40],"is":[4],"increased":[5],"in":[6,73,86,97,128,154,176,183,229,241],"asthma,":[7],"but":[8,61],"the":[9,15,54,196],"mechanisms":[10],"controlling":[11],"its":[12],"production,":[13],"including":[14],"effects":[16],"of":[17,37,63,65,136,187],"T-helper":[18],"type":[19],"2":[20,169],"(Th2)":[21],"cytokines,":[22],"are":[23],"poorly":[24],"understood.":[25],"In":[26],"mouse":[27],"and":[28,95,107,112,117,138,159,185,201,222],"submerged":[29],"human":[30,75,82],"epithelial":[31,84,130,155],"cells,":[32],"Th2":[33,217],"cytokines":[34],"inhibit":[35],"expression":[36,62,94,114,165,170,221],"inducible":[38],"synthase":[41],"(iNOS).":[42],"Arginases":[43],"have":[44],"been":[45,70],"proposed":[46],"to":[47,49,58,99,214,231,236],"contribute":[48],"asthma":[50],"pathogenesis":[51],"by":[52],"limiting":[53],"arginine":[55],"substrate":[56],"available":[57],"NOS":[59],"enzymes,":[60],"any":[64],"these":[66],"enzymes":[67],"has":[68],"not":[69,172,193,204],"extensively":[71],"studied":[72],"primary":[74,81],"cells.":[76,156],"OBJECTIVES:":[77],"We":[78],"hypothesized":[79],"that":[80,216],"airway":[83],"cells":[85,131],"air-liquid":[87],"interface":[88],"(ALI)":[89],"culture":[90],"would":[91],"increase":[92],"iNOS":[93,106,122,147,157,177,199,220],"activity":[96,123,160],"response":[98,230],"IL-13,":[100,232],"while":[101,167],"decreasing":[102],"arginase":[103,108,168,188,225,234],"expression.":[104],"METHODS:":[105],"mRNA":[109,148,200],"(real-time":[110],"PCR)":[111],"protein":[113,158,164,178,202,227],"(Western":[115],"blot":[116],"immunofluorescence)":[118],"as":[119,121],"well":[120],"(nitrite":[124],"levels)":[125],"were":[126,203],"measured":[127],"ALI":[129],"cultured":[132],"from":[133],"bronchial":[134],"brushings":[135],"normal":[137],"asthmatic":[139],"subjects":[140],"following":[141],"IL-13":[142,145],"stimulation.":[143],"RESULTS:":[144],"up-regulated":[146],"primarily":[149],"at":[150],"a":[151],"transcriptional":[152],"level":[153],"also":[161],"increased,":[162],"arginase1":[163],"decreased":[166],"did":[171,192],"change.":[173],"The":[174],"changes":[175,182],"correlated":[179],"strongly":[180],"with":[181,210],"nitrites,":[184],"inclusion":[186],"(1":[189],"or":[190],"2)":[191],"substantially":[194,237],"change":[195],"relationship.":[197],"Interestingly,":[198],"correlated.":[205],"CONCLUSIONS:":[206],"These":[207],"results":[208,213],"contrast":[209],"many":[211],"previous":[212],"confirm":[215],"stimuli":[218],"enhance":[219],"activity.":[223],"While":[224],"1":[226],"decreases":[228],"neither":[233],"appears":[235],"impact":[238],"nitrite":[239],"levels":[240],"this":[242],"system.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}