{"id":"https://openalex.org/W2043939417","doi":"https://doi.org/10.1074/jbc.m111.262485","title":"Impact of Self-association on Function of Apolipoprotein A-I","display_name":"Impact of Self-association on Function of Apolipoprotein A-I","publication_year":2011,"publication_date":"2011-08-11","ids":{"openalex":"https://openalex.org/W2043939417","doi":"https://doi.org/10.1074/jbc.m111.262485","mag":"2043939417","pmid":"https://pubmed.ncbi.nlm.nih.gov/21835924","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195568"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.262485","doi":"https://doi.org/10.1074/jbc.m111.262485","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.262485","pdf_url":"http://www.jbc.org/article/S0021925820737671/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820737671/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102822094","display_name":"Shobini Jayaraman","orcid":"https://orcid.org/0000-0003-1616-5347","observed_orcids":["https://orcid.org/0000-0003-1616-5347"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobini Jayaraman","raw_affiliation_strings":["Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066697896","display_name":"Sumiko Abe-Dohmae","orcid":"https://orcid.org/0009-0003-8207-8775","observed_orcids":["https://orcid.org/0009-0003-8207-8775"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumiko Abe-Dohmae","raw_affiliation_strings":["Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101897882","display_name":"Shinji Yokoyama","orcid":"https://orcid.org/0000-0003-0552-9168","observed_orcids":["https://orcid.org/0000-0003-0552-9168"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Yokoyama","raw_affiliation_strings":["Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055223538","display_name":"Giorgio Cavigiolio","orcid":"https://orcid.org/0000-0002-1622-0628","observed_orcids":["https://orcid.org/0000-0002-1622-0628"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giorgio Cavigiolio","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, Oakland, California 94609. Electronic address: gcavigiolio@chori.org","Children's Hospital Oakland Research Institute Oakland California, 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, Oakland, California 94609. Electronic address: gcavigiolio@chori.org","institution_ids":[]},{"raw_affiliation_string":"Children's Hospital Oakland Research Institute Oakland California, 94609","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055223538"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.9419,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.90287559,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"286","issue":"41","first_page":"35610","last_page":"35623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9990000128746033},{"id":"https://openalex.org/keywords/self-association","display_name":"self-association","score":0.9100000262260437},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.7630000114440918},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.43799999356269836},{"id":"https://openalex.org/keywords/lipid-binding","display_name":"lipid binding","score":0.5289999842643738},{"id":"https://openalex.org/keywords/anti-atherogenic-activity","display_name":"anti-atherogenic activity","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.6336965560913086},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5656228065490723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4165528118610382},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.41518735885620117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3395187556743622},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33691757917404175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33377164602279663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2733275294303894},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24284875392913818},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24229368567466736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2323133945465088},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.17002040147781372},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.262485","doi":"https://doi.org/10.1074/jbc.m111.262485","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.262485","pdf_url":"http://www.jbc.org/article/S0021925820737671/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2461085","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195568","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3195568","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3195568","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21835924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21835924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.262485","doi":"https://doi.org/10.1074/jbc.m111.262485","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.262485","pdf_url":"http://www.jbc.org/article/S0021925820737671/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2592200337","display_name":null,"funder_award_id":"HL026355","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G334484090","display_name":"Apolipoprotein conformation in amyloid and cardiovascular diseases","funder_award_id":"R01GM067260","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3878493874","display_name":null,"funder_award_id":"GM067260","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G623057916","display_name":"Roles of ABC transporters in cellular cholesterol transport and inflammatory response","funder_award_id":"21591164","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6991771339","display_name":"Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine","funder_award_id":"21390188","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8280953071","display_name":null,"funder_award_id":"HL026355","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308294","display_name":"Tobacco-Related Disease Research Program","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043939417.pdf","grobid_xml":"https://content.openalex.org/works/W2043939417.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W419441076","https://openalex.org/W1486725534","https://openalex.org/W1506445145","https://openalex.org/W1522309562","https://openalex.org/W1549731635","https://openalex.org/W1573915513","https://openalex.org/W1585699199","https://openalex.org/W1598788587","https://openalex.org/W1606615180","https://openalex.org/W1963603983","https://openalex.org/W1966690032","https://openalex.org/W1968196140","https://openalex.org/W1969232152","https://openalex.org/W1971791009","https://openalex.org/W1972378411","https://openalex.org/W1973241402","https://openalex.org/W1974864595","https://openalex.org/W1977323867","https://openalex.org/W1977353914","https://openalex.org/W1978194142","https://openalex.org/W1985404425","https://openalex.org/W1986524045","https://openalex.org/W1986838916","https://openalex.org/W1987870033","https://openalex.org/W1991376375","https://openalex.org/W1994543234","https://openalex.org/W1994837493","https://openalex.org/W1998445536","https://openalex.org/W2003889403","https://openalex.org/W2003949553","https://openalex.org/W2004137387","https://openalex.org/W2005423891","https://openalex.org/W2006324786","https://openalex.org/W2007155340","https://openalex.org/W2007340378","https://openalex.org/W2014945371","https://openalex.org/W2020581548","https://openalex.org/W2021141680","https://openalex.org/W2023919356","https://openalex.org/W2024653871","https://openalex.org/W2028612087","https://openalex.org/W2029902514","https://openalex.org/W2033299688","https://openalex.org/W2034021245","https://openalex.org/W2035467780","https://openalex.org/W2036362108","https://openalex.org/W2038401448","https://openalex.org/W2039682183","https://openalex.org/W2041670522","https://openalex.org/W2042411476","https://openalex.org/W2044465436","https://openalex.org/W2045474288","https://openalex.org/W2049825478","https://openalex.org/W2050178956","https://openalex.org/W2050846920","https://openalex.org/W2052288531","https://openalex.org/W2055067929","https://openalex.org/W2055823448","https://openalex.org/W2062344966","https://openalex.org/W2063246145","https://openalex.org/W2066894739","https://openalex.org/W2073072310","https://openalex.org/W2073276199","https://openalex.org/W2075400864","https://openalex.org/W2076021360","https://openalex.org/W2076775566","https://openalex.org/W2077556715","https://openalex.org/W2081113495","https://openalex.org/W2082705747","https://openalex.org/W2088357437","https://openalex.org/W2090399507","https://openalex.org/W2092266405","https://openalex.org/W2094768566","https://openalex.org/W2102867738","https://openalex.org/W2107117207","https://openalex.org/W2107768042","https://openalex.org/W2117383170","https://openalex.org/W2119092533","https://openalex.org/W2125448572","https://openalex.org/W2127055642","https://openalex.org/W2128583836","https://openalex.org/W2134551277","https://openalex.org/W2134969640","https://openalex.org/W2135774757","https://openalex.org/W2139564185","https://openalex.org/W2141016353","https://openalex.org/W2155406689","https://openalex.org/W2159282739","https://openalex.org/W2163483547","https://openalex.org/W2186767169","https://openalex.org/W2310592009"],"related_works":["https://openalex.org/W4413010509","https://openalex.org/W767057125","https://openalex.org/W2791106127","https://openalex.org/W1953094574","https://openalex.org/W1558786268","https://openalex.org/W4393138862","https://openalex.org/W4311989628","https://openalex.org/W3120562007","https://openalex.org/W1564061572","https://openalex.org/W1887901770"],"abstract_inverted_index":{"Self-association":[0],"is":[1,34,175,192],"an":[2,27,53,215],"inherent":[3],"property":[4,88],"of":[5,9,21,56,65,68,84,89,95,104,137,149,160,173,179,187,201,207,234],"the":[6,17,38,66,93,99,135,158,176,224,240],"lipid-free":[7,32],"forms":[8],"several":[10],"exchangeable":[11],"apolipoproteins,":[12],"including":[13],"apolipoprotein":[14],"A-I":[15],"(apoA-I),":[16],"main":[18,177],"protein":[19],"component":[20],"high":[22,138],"density":[23],"lipoproteins":[24],"(HDL)":[25],"and":[26,77,101,123,165,227,244],"established":[28],"antiatherogenic":[29],"factor.":[30],"Monomeric":[31,121],"apoA-I":[33,62,69,105,125,174,211,247],"believed":[35],"to":[36,61,74,91,144,246],"be":[37],"biologically":[39],"active":[40],"species,":[41],"but":[42],"abnormal":[43],"conditions,":[44],"such":[45],"as":[46,106,108,230],"specific":[47,150],"natural":[48],"mutations":[49],"or":[50],"oxidation,":[51],"produce":[52],"altered":[54],"state":[55,243],"self-association":[57,96,229,242],"that":[58,154],"may":[59,238],"contribute":[60,245],"dysfunction.":[63,248],"Replacement":[64],"tryptophans":[67],"with":[70,131],"phenylalanines":[71],"(\u0394W-apoA-I)":[72],"leads":[73],"unusually":[75],"large":[76],"stable":[78,202],"self-associated":[79,140,151,208],"species.":[80],"We":[81],"took":[82],"advantage":[83],"this":[85],"unique":[86],"solution":[87],"\u0394W-apoA-I":[90,122],"analyze":[92],"role":[94],"in":[97,119,163,180],"determining":[98],"structure":[100],"lipid-binding":[102],"properties":[103],"well":[107],"ATP-binding":[109],"cassette":[110],"A1":[111],"(ABCA1)-mediated":[112],"cellular":[113,128,188],"lipid":[114,129,167,182,189],"release,":[115],"a":[116,231],"relevant":[117],"pathway":[118],"atherosclerosis.":[120],"wild-type":[124],"activated":[126],"ABCA1-mediated":[127,166,216],"release":[130,168,190],"similar":[132],"efficiencies,":[133],"whereas":[134,185],"efficiency":[136,191],"order":[139],"species":[141,209],"was":[142],"reduced":[143,196],"less":[145],"than":[146],"50%.":[147],"Analysis":[148],"subclasses":[152],"revealed":[153],"different":[155],"factors":[156],"influence":[157],"rate":[159],"HDL":[161],"formation":[162,200],"vitro":[164,181],"efficiency.":[169],"The":[170],"\u03b1-helix-forming":[171],"ability":[172],"determinant":[178],"solubilization":[183],"rates,":[184],"loss":[186],"mainly":[193],"caused":[194],"by":[195,199],"structural":[197],"flexibility":[198],"quaternary":[203],"interactions.":[204],"Thus,":[205],"stabilization":[206],"impairs":[210],"biological":[212],"activity":[213],"through":[214],"mechanism.":[217],"These":[218],"results":[219],"afford":[220],"mechanistic":[221],"insights":[222],"into":[223],"ABCA1":[225],"reaction":[226],"suggest":[228],"functional":[232],"feature":[233],"apoA-I.":[235],"Physiologic":[236],"mechanisms":[237],"alter":[239],"native":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}