{"id":"https://openalex.org/W2043936345","doi":"https://doi.org/10.1093/carcin/5.12.1557","title":"Metabolism of 1-nitro[14C]pyrene in vivo in the rat and mutagenicity of urinary metabolites","display_name":"Metabolism of 1-nitro[14C]pyrene in vivo in the rat and mutagenicity of urinary metabolites","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2043936345","doi":"https://doi.org/10.1093/carcin/5.12.1557","mag":"2043936345","pmid":"https://pubmed.ncbi.nlm.nih.gov/6499108"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/5.12.1557","doi":"https://doi.org/10.1093/carcin/5.12.1557","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/5.12.1557","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012844543","display_name":"Louise M. Ball","orcid":"https://orcid.org/0000-0002-1758-3228","observed_orcids":["https://orcid.org/0000-0002-1758-3228"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.M. Ball","raw_affiliation_strings":["Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086031732","display_name":"Michael J. Kohan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. Kohan","raw_affiliation_strings":["Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110082955","display_name":"Jeff Inmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. Inmon","raw_affiliation_strings":["Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091863262","display_name":"Larry D. Claxton","orcid":"https://orcid.org/0000-0001-7455-1583","observed_orcids":["https://orcid.org/0000-0001-7455-1583"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.D. Claxton","raw_affiliation_strings":["Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park NC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089591239","display_name":"Joellen Lewtas Huisingh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lewtas","raw_affiliation_strings":["Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle ParkNC 27711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle ParkNC 27711, USA","institution_ids":["https://openalex.org/I1302368450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1302368450"],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":5.1221,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.96328158,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"12","first_page":"1557","last_page":"1564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-nitropyrene","display_name":"1-nitropyrene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fecal-metabolites","display_name":"fecal metabolites","score":0.8059999942779541},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ames-test","display_name":"Ames test","score":0.640999972820282},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta98","display_name":"Salmonella typhimurium TA98","score":0.8840000033378601},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.871999979019165},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.6729999780654907},{"id":"https://openalex.org/keywords/carcinogens","display_name":"carcinogens","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8122438788414001},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8033511638641357},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.6742072105407715},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6537014245986938},{"id":"https://openalex.org/C117632636","wikidata":"https://www.wikidata.org/wiki/Q30912","display_name":"Ames test","level":4,"score":0.6354787349700928},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6077966094017029},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5910000801086426},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.559486985206604},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5263125896453857},{"id":"https://openalex.org/C2776648616","wikidata":"https://www.wikidata.org/wiki/Q409216","display_name":"Glucuronic acid","level":3,"score":0.5238552093505859},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.5226961374282837},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.4791623651981354},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4577447772026062},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.43849191069602966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4229537844657898},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20124313235282898},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.18133768439292908},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11509078741073608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10642498731613159},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10202473402023315},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011721","descriptor_name":"Pyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/5.12.1557","doi":"https://doi.org/10.1093/carcin/5.12.1557","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/5.12.1557","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:6499108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6499108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080175528","https://openalex.org/W1514498928","https://openalex.org/W4256377948","https://openalex.org/W2045937169","https://openalex.org/W1658067342","https://openalex.org/W1492360045","https://openalex.org/W1964363705","https://openalex.org/W2004793476","https://openalex.org/W1999144686","https://openalex.org/W217047739"],"abstract_inverted_index":{"The":[0,60,204,220],"metabolic":[1,173],"fate":[2],"of":[3,22,28,35,38,54,65,95,130,146,159,168,196,199,206,217,223],"the":[4,18,39,46,55,96,114,133,147,157,183,194,207,224,236],"bacterial":[5],"mutagen,":[6],"environmental":[7],"pollutant":[8],"and":[9,43,62,69,82,121,132,138,181,189,216],"potential":[10],"carcinogen":[11],"1-nitropyrene":[12],"(NP)":[13],"has":[14],"been":[15,58],"investigated":[16],"in":[17,41,45,106,127,156,193,226,242,246],"rat.":[19],"Over":[20],"half":[21],"an":[23],"i.p.":[24],"dose":[25,40,56,97],"(10":[26],"mg/kg)":[27],"1-nitro[14C]pyrene":[29],"was":[30,98,142,176,228],"excreted":[31,99,105],"within":[32],"24":[33],"h":[34,50],"dosing,":[36],"15%":[37],"urine":[42,158],"40%":[44],"faeces.":[47],"After":[48],"96":[49],"greater":[51],"than":[52,93],"80%":[53],"had":[57],"recovered.":[59],"urinary":[61],"fecal":[63,238],"metabolites":[64,102,129,136,209,239],"NP":[66,169],"were":[67,103,119,210,240],"separated":[68],"quantitated":[70],"by":[71,75,144],"h.p.l.c.,":[72],"then":[73],"identified":[74,118],"high":[76],"resolution":[77],"gas":[78],"chromatography/mass":[79],"spectrometry":[80],"(h.r.g.c./m.s.)":[81],"comparison":[83],"with":[84,110,162,179,182],"synthetic":[85],"reference":[86],"compounds,":[87],"where":[88],"available.":[89],"Very":[90],"little":[91],"(less":[92],"5%)":[94],"unchanged.":[100],"Urinary":[101],"all":[104],"conjugate":[107],"form,":[108],"mainly":[109],"glucuronic":[111],"acid.":[112],"Among":[113],"principal":[115],"metabolite":[116],"fractions":[117],"3-hydroxy-1-nitropyrene":[120],"8-hydroxy-1-nitropyrene":[122],"(already":[123],"known":[124],"as":[125],"hepatic":[126],"vitro":[128],"1-nitropyrene)":[131],"hitherto":[134],"unreported":[135],"6-hydroxy-N-acetyl-1-aminopyrene":[137,180],"8-hydroxy-N-acetyl-1-aminopyrene.":[139],"Mutagenic":[140],"activity":[141],"detected,":[143],"means":[145],"Ames":[148],"Salmonella":[149],"(strain":[150],"TA":[151],"98)":[152],"plate":[153],"incorporation":[154],"assay,":[155],"rats":[160],"dosed":[161],"NP.":[163],"This":[164],"mutagenicity,":[165],"unlike":[166],"that":[167],"itself,":[170],"required":[171],"exogenous":[172],"activation.":[174],"It":[175],"predominantly":[177],"associated":[178],"nitropyrene":[184],"phenols":[185],"(specific":[186],"mutagenicity":[187],"600":[188],"700":[190],"rev/nmol":[191],"respectively":[192],"presence":[195],"0.6":[197],"mg":[198],"S9":[200],"protein":[201],"per":[202],"plate).":[203],"majority":[205],"residual":[208],"polar,":[211],"refractory":[212],"to":[213,233,244],"enzymic":[214,234],"hydrolysis,":[215],"low":[218],"mutagenicity.":[219],"major":[221],"proportion":[222],"14C":[225],"feces":[227],"not":[229],"extractable":[230,237],"or":[231],"amenable":[232],"hydrolysis;":[235],"similar":[241],"nature":[243],"those":[245],"urine.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
