{"id":"https://openalex.org/W2043930674","doi":"https://doi.org/10.1093/nar/17.10.3735","title":"Selective hydrolysis by exo- and endonucleases of phosphodiester bonds adjacent to an apurinic site","display_name":"Selective hydrolysis by exo- and endonucleases of phosphodiester bonds adjacent to an apurinic site","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2043930674","doi":"https://doi.org/10.1093/nar/17.10.3735","mag":"2043930674","pmid":"https://pubmed.ncbi.nlm.nih.gov/2543953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/317854"},"language":"en","primary_location":{"id":"doi:10.1093/nar/17.10.3735","doi":"https://doi.org/10.1093/nar/17.10.3735","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/17.10.3735","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC317854","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065812167","display_name":"Michael Weinfeld","orcid":"https://orcid.org/0000-0002-8773-1425","observed_orcids":["https://orcid.org/0000-0002-8773-1425"]},"institutions":[{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Michael Weinfeld","raw_affiliation_strings":["Department of Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I4405258411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039716848","display_name":"Michel Liuzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michel Liuzzi","raw_affiliation_strings":["Laboratory of Molecular Genetics and Carcinogenesis, Department of Medicine, Cross Cancer Institute Edmonton. Alberta T6G 1Z2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics and Carcinogenesis, Department of Medicine, Cross Cancer Institute Edmonton. Alberta T6G 1Z2, Canada","institution_ids":["https://openalex.org/I4405258411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060826493","display_name":"Malcolm C. Paterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Malcolm C. Paterson","raw_affiliation_strings":["Laboratory of Molecular Genetics and Carcinogenesis, Department of Medicine, Cross Cancer Institute Edmonton. Alberta T6G 1Z2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics and Carcinogenesis, Department of Medicine, Cross Cancer Institute Edmonton. Alberta T6G 1Z2, Canada","institution_ids":["https://openalex.org/I4405258411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065812167"],"corresponding_institution_ids":["https://openalex.org/I4405258411"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":0.9692,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.74083663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"10","first_page":"3735","last_page":"3745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apurinic-sites","display_name":"apurinic sites","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phosphodiester-bond-hydrolysis","display_name":"phosphodiester bond hydrolysis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/snake-venom-phosphodiesterase","display_name":"snake venom phosphodiesterase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nuclease-p1","display_name":"nuclease P1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/s1-nuclease","display_name":"S1 nuclease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mung-bean-nuclease","display_name":"mung bean nuclease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/depurination","display_name":"depurination","score":0.5979999899864197},{"id":"https://openalex.org/keywords/model-compounds","display_name":"model compounds","score":0.5059999823570251},{"id":"https://openalex.org/keywords/aldehyde-groups","display_name":"aldehyde groups","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C34737976","wikidata":"https://www.wikidata.org/wiki/Q903582","display_name":"Depurination","level":3,"score":0.929045557975769},{"id":"https://openalex.org/C38441620","wikidata":"https://www.wikidata.org/wiki/Q863983","display_name":"Phosphodiester bond","level":4,"score":0.8868067264556885},{"id":"https://openalex.org/C2777709666","wikidata":"https://www.wikidata.org/wiki/Q192454","display_name":"Deoxyribose","level":3,"score":0.8784905076026917},{"id":"https://openalex.org/C150777479","wikidata":"https://www.wikidata.org/wiki/Q176783","display_name":"AP site","level":4,"score":0.8027684688568115},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.7751104831695557},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6182844638824463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5795219540596008},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5389180779457092},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5286363363265991},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5203263759613037},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.4495231509208679},{"id":"https://openalex.org/C2777028655","wikidata":"https://www.wikidata.org/wiki/Q415601","display_name":"Endonuclease","level":3,"score":0.4368099570274353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27485916018486023},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13962122797966003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001080","descriptor_name":"Apurinic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001080","descriptor_name":"Apurinic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011119","descriptor_name":"Polynucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/17.10.3735","doi":"https://doi.org/10.1093/nar/17.10.3735","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/17.10.3735","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:40176","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC317854","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:317854","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/317854","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:2543953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2543953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:40176","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC317854","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1377731","https://openalex.org/W15763580","https://openalex.org/W179600832","https://openalex.org/W953047224","https://openalex.org/W1483558920","https://openalex.org/W1519643561","https://openalex.org/W1620974602","https://openalex.org/W1830811929","https://openalex.org/W1948333092","https://openalex.org/W1982059131","https://openalex.org/W2005500828","https://openalex.org/W2008470045","https://openalex.org/W2009811909","https://openalex.org/W2017863429","https://openalex.org/W2026414367","https://openalex.org/W2040100388","https://openalex.org/W2044970196","https://openalex.org/W2046561854","https://openalex.org/W2051688284","https://openalex.org/W2051862401","https://openalex.org/W2072083287","https://openalex.org/W2076443882","https://openalex.org/W2083361941","https://openalex.org/W2084695608","https://openalex.org/W2086248335","https://openalex.org/W2093190265","https://openalex.org/W2097432692","https://openalex.org/W2116234651","https://openalex.org/W2128442121","https://openalex.org/W2345923826"],"related_works":["https://openalex.org/W1985676731","https://openalex.org/W1592472596","https://openalex.org/W1994695947","https://openalex.org/W1545094817","https://openalex.org/W2058272044","https://openalex.org/W2038244881","https://openalex.org/W4324013453","https://openalex.org/W2087245943","https://openalex.org/W1593086337","https://openalex.org/W2201944037"],"abstract_inverted_index":{"Partial":[0],"depurination":[1],"of":[2,31,47,61,69,89,174],"d-ApA":[3],"produced":[4],"two":[5],"UV260nm-absorbing":[6],"isomers,":[7],"d-SpA":[8,70,96,196],"and":[9,66,144,188,197],"d-ApS":[10,132,155],"(where":[11],"S":[12],"represents":[13],"the":[14,29,59,162,166,181,185,193],"depurinated":[15],"deoxyribose":[16,64],"sugar),":[17],"that":[18,161],"provided":[19],"simple":[20],"model":[21],"compounds":[22],"with":[23,55,131,134,184,195],"which":[24,84],"to":[25,33,57,75,86,97,111],"examine,":[26],"by":[27,40,52],"HPLC,":[28],"response":[30],"nucleases":[32],"phosphodiester":[34],"bonds":[35],"flanked":[36],"3'":[37],"or":[38],"5'":[39],"an":[41,62,81,151],"apurinic":[42],"site.":[43],"The":[44,159],"structural":[45],"identity":[46],"each":[48],"compound":[49],"was":[50,177],"established":[51],"(i)":[53],"reaction":[54],"methoxyamine":[56],"confirm":[58],"presence":[60],"abasic":[63],"group,":[65],"(ii)":[67],"degradation":[68],"under":[71],"mild":[72],"alkaline":[73],"conditions":[74],"distinguish":[76],"it":[77],"from":[78,192],"d-ApS.":[79,105,198],"At":[80],"enzyme":[82,182],"concentration":[83],"led":[85],"complete":[87],"hydrolysis":[88],"d-ApA,":[90],"snake":[91],"venom":[92],"phosphodiesterase":[93,108],"readily":[94],"cleaved":[95],"5'-dAMP":[98],"but":[99,120,156],"had":[100],"no":[101,190],"discernible":[102],"effect":[103],"on":[104,113],"Calf":[106],"spleen":[107],"also":[109],"failed":[110],"act":[112],"one":[114],"isomer,":[115],"in":[116,150],"this":[117],"instance":[118],"d-SpA,":[119],"additionally":[121],"reacted":[122],"at":[123,165],"a":[124],"much":[125],"slower":[126],"rate":[127],"(approximately":[128],"100":[129],"fold)":[130],"than":[133],"d-ApA.":[135],"Three":[136],"single-strand":[137],"specific":[138],"endonucleases,":[139],"nuclease":[140,142],"P1,":[141],"S1":[143],"mung":[145],"bean":[146],"nuclease,":[147],"all":[148],"responded":[149],"identical":[152],"manner,":[153],"hydrolysing":[154],"not":[157],"d-SpA.":[158],"possibility":[160],"aldehyde":[163],"group":[164],"AP":[167],"sites":[168],"might":[169],"be":[170],"responsible":[171],"for":[172],"some":[173],"these":[175],"observations":[176],"rejected":[178],"after":[179],"repeating":[180],"digestions":[183],"methoxyamine-capped":[186],"molecules":[187],"observing":[189],"differences":[191],"reactions":[194]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
