{"id":"https://openalex.org/W2043904611","doi":"https://doi.org/10.1111/j.1440-1827.1977.tb00178.x","title":"EXTRARENAL RENIN\u2010SECRETING TUMOR ASSOCIATED WITH HYPERTENSION","display_name":"EXTRARENAL RENIN\u2010SECRETING TUMOR ASSOCIATED WITH HYPERTENSION","publication_year":1977,"publication_date":"1977-07-01","ids":{"openalex":"https://openalex.org/W2043904611","doi":"https://doi.org/10.1111/j.1440-1827.1977.tb00178.x","mag":"2043904611","pmid":"https://pubmed.ncbi.nlm.nih.gov/910630"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1827.1977.tb00178.x","doi":"https://doi.org/10.1111/j.1440-1827.1977.tb00178.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1827.1977.tb00178.x","pdf_url":null,"source":{"id":"https://openalex.org/S4390963336","display_name":"Acta Pathologica Japonica","issn_l":"0001-6632","issn":["0001-6632"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pathologica Japonica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102113182","display_name":"Hiroyuki Ohmori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Ohmori","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113684939","display_name":"Makoto Motoi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Motoi","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102057250","display_name":"Hiromichi Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Sato","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012528405","display_name":"Akira Tsutsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Tsutsumi","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110007284","display_name":"Katsuo Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuo Ogawa","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hisako Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisako Fujiwara","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083730731","display_name":"Toshiaki Kageyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Kageyama","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024363848","display_name":"Takeo Yoshinouchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Yoshinouchi","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024648214","display_name":"Hisamitsu Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisamitsu Yokoyama","raw_affiliation_strings":["*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pathology, Department of Ophthalmology, Department of Neurosurgery, Department of Third Internal Medicine, Okayama University Medical School, Okayama","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"27","issue":"4","first_page":"567","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orbital-tumors","display_name":"orbital tumors","score":0.5260000228881836},{"id":"https://openalex.org/keywords/hyperreninemia","display_name":"hyperreninemia","score":0.7250000238418579},{"id":"https://openalex.org/keywords/secondary-hyperaldosteronism","display_name":"secondary hyperaldosteronism","score":0.9779999852180481},{"id":"https://openalex.org/keywords/malignant-hypertension","display_name":"malignant hypertension","score":0.8309999704360962},{"id":"https://openalex.org/keywords/renovascular-hypertension","display_name":"renovascular hypertension","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hemangiopericytoma","display_name":"hemangiopericytoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.7720000147819519},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/adolescent-patient","display_name":"adolescent patient","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6439896821975708},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5931776165962219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5719552636146545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3437826633453369},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.19889435172080994}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006393","descriptor_name":"Hemangiopericytoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006393","descriptor_name":"Hemangiopericytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006393","descriptor_name":"Hemangiopericytoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009918","descriptor_name":"Orbital Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009918","descriptor_name":"Orbital Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009918","descriptor_name":"Orbital Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1827.1977.tb00178.x","doi":"https://doi.org/10.1111/j.1440-1827.1977.tb00178.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1827.1977.tb00178.x","pdf_url":null,"source":{"id":"https://openalex.org/S4390963336","display_name":"Acta Pathologica Japonica","issn_l":"0001-6632","issn":["0001-6632"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pathologica Japonica","raw_type":"journal-article"},{"id":"pmid:910630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/910630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pathologica japonica","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W78874822","https://openalex.org/W658407570","https://openalex.org/W1761783115","https://openalex.org/W1903317103","https://openalex.org/W1953000284","https://openalex.org/W1967011793","https://openalex.org/W1986477804","https://openalex.org/W1986577396","https://openalex.org/W1989650090","https://openalex.org/W1991841545","https://openalex.org/W1996502686","https://openalex.org/W2009807342","https://openalex.org/W2028872990","https://openalex.org/W2031051250","https://openalex.org/W2032107056","https://openalex.org/W2036418733","https://openalex.org/W2036653432","https://openalex.org/W2041092104","https://openalex.org/W2046011735","https://openalex.org/W2046666672","https://openalex.org/W2053471352","https://openalex.org/W2061424206","https://openalex.org/W2062182713","https://openalex.org/W2066828304","https://openalex.org/W2072153204","https://openalex.org/W2082757943","https://openalex.org/W2084150614","https://openalex.org/W2088636107","https://openalex.org/W2117168719","https://openalex.org/W2126550374","https://openalex.org/W2159022187","https://openalex.org/W2244536665","https://openalex.org/W2317726702","https://openalex.org/W2396042215","https://openalex.org/W2398215322","https://openalex.org/W2400746123","https://openalex.org/W2409458332","https://openalex.org/W2410435903","https://openalex.org/W2410564858","https://openalex.org/W2414290389","https://openalex.org/W2419334401","https://openalex.org/W2421475670","https://openalex.org/W2427168012"],"related_works":["https://openalex.org/W1953000284","https://openalex.org/W110231368","https://openalex.org/W2036418733","https://openalex.org/W2470448275","https://openalex.org/W2061424206","https://openalex.org/W2397481119","https://openalex.org/W2407080919","https://openalex.org/W7167540149","https://openalex.org/W2413166478","https://openalex.org/W2436303957"],"abstract_inverted_index":{"Described":[0],"herein":[1],"is":[2],"an":[3],"autopsy":[4],"case":[5],"of":[6,24,31,45,68,89],"a":[7,20,46,58],"16-year-old":[8],"female":[9],"with":[10],"severe":[11],"hypertension,":[12],"hyperreninemia":[13],"and":[14,71,93,114,118,132,141],"secondary":[15],"aldosteronism.":[16],"She":[17],"had":[18,19],"progressively":[21],"growing":[22],"tumor":[23,34,69,101,108],"her":[25],"right":[26,115],"orbita":[27],"from":[28],"the":[29,52,80,87,100,107,111,121,124,139],"age":[30],"4.":[32],"The":[33],"was":[35,49,56,83,102],"partially":[36,103],"excised":[37,53],"13":[38],"months":[39],"before":[40],"death.":[41],"A":[42],"high":[43],"content":[44],"renin-like":[47],"material":[48],"detected":[50],"in":[51,65],"tumor,":[54,129],"which":[55],"histologically":[57],"hemangiopericytoma.":[59],"Bowie":[60],"stain":[61],"revealed":[62],"some":[63,76],"granules":[64],"small":[66],"number":[67],"cells":[70],"electron":[72],"microscopic":[73],"study":[74],"showed":[75],"cytoplasmic":[77],"granules.":[78],"Following":[79],"operation,":[81],"hypertension":[82,131,134],"somewhat":[84],"improved,":[85],"but":[86],"levels":[88],"plasma":[90,94],"renin":[91],"activity":[92],"aldosterone":[95],"concentration":[96],"remained":[97],"elevated,":[98],"because":[99],"resected.":[104],"At":[105],"autopsy,":[106],"invaded":[109],"into":[110],"cranial":[112],"base":[113],"frontal":[116],"lobe,":[117],"metastasized":[119],"to":[120],"lungs.":[122],"In":[123],"present":[125],"case,":[126],"renal":[127],"renin-secreting":[128],"malignant":[130],"renovascular":[133],"were":[135],"ruled":[136],"out":[137],"by":[138],"clinical":[140],"pathological":[142],"studies.":[143]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
