{"id":"https://openalex.org/W2043900976","doi":"https://doi.org/10.1590/s0004-27302002000400007","title":"Etiopatog\u00eanese Molecular dos Tumores Corticotr\u00f3ficos","display_name":"Etiopatog\u00eanese Molecular dos Tumores Corticotr\u00f3ficos","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2043900976","doi":"https://doi.org/10.1590/s0004-27302002000400007","mag":"2043900976"},"language":"pt","primary_location":{"id":"doi:10.1590/s0004-27302002000400007","doi":"https://doi.org/10.1590/s0004-27302002000400007","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302002000400007","pdf_url":"https://www.scielo.br/j/abem/a/3ThMQZ6FDWyw7CHTKRdMXkt/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/abem/a/3ThMQZ6FDWyw7CHTKRdMXkt/?lang=pt&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044895027","display_name":"Sonir Roberto Rauber Antonini","orcid":"https://orcid.org/0000-0003-4778-8803","observed_orcids":["https://orcid.org/0000-0003-4778-8803"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sonir R. Antonini","raw_affiliation_strings":["USP","USP, Ribeir\u00e3o Preto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"USP, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040413261","display_name":"Margaret de Castro","orcid":"https://orcid.org/0000-0003-4932-4623","observed_orcids":["https://orcid.org/0000-0003-4932-4623"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Margaret de Castro","raw_affiliation_strings":["USP","USP, Ribeir\u00e3o Preto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"USP, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"4","first_page":"361","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotroph-tumors","display_name":"corticotroph tumors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.7900000214576721},{"id":"https://openalex.org/keywords/etiopathogenesis","display_name":"etiopathogenesis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.5989999771118164},{"id":"https://openalex.org/keywords/anterior-pituitary-development","display_name":"anterior pituitary development","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7080000042915344},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pituitary-tumor-transforming-gene","display_name":"PTTG","score":0.9760000109672546},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor-receptor","display_name":"corticotropin-releasing factor receptor","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vasopressin-receptor","display_name":"vasopressin receptor","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5364229679107666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4344441890716553},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.40074729919433594}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1590/s0004-27302002000400007","doi":"https://doi.org/10.1590/s0004-27302002000400007","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302002000400007","pdf_url":"https://www.scielo.br/j/abem/a/3ThMQZ6FDWyw7CHTKRdMXkt/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S0004-27302002000400007","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0004-27302002000400007","pdf_url":null,"source":{"id":"https://openalex.org/S4306402308","display_name":"The Scientific Electronic Library Online (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116822","host_organization_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I4210116822"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.46 n.4 2002","raw_type":"info:eu-repo/semantics/other"},{"id":"mag:2741570239","doi":null,"is_oa":false,"landing_page_url":"http://www.scielo.br/pdf/abem/v46n4/12791.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1590/s0004-27302002000400007","doi":"https://doi.org/10.1590/s0004-27302002000400007","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302002000400007","pdf_url":"https://www.scielo.br/j/abem/a/3ThMQZ6FDWyw7CHTKRdMXkt/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043900976.pdf","grobid_xml":"https://content.openalex.org/works/W2043900976.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W41629486","https://openalex.org/W99442063","https://openalex.org/W188824656","https://openalex.org/W232934358","https://openalex.org/W308712928","https://openalex.org/W775143871","https://openalex.org/W1551820272","https://openalex.org/W1556820154","https://openalex.org/W1586640515","https://openalex.org/W1600935440","https://openalex.org/W1611935912","https://openalex.org/W1778706801","https://openalex.org/W1812895422","https://openalex.org/W1965093277","https://openalex.org/W1967619163","https://openalex.org/W1969304196","https://openalex.org/W1973355614","https://openalex.org/W1974071386","https://openalex.org/W1974084985","https://openalex.org/W1974359182","https://openalex.org/W1974366727","https://openalex.org/W1978050122","https://openalex.org/W1982361561","https://openalex.org/W1983067877","https://openalex.org/W1986924305","https://openalex.org/W1997547099","https://openalex.org/W1997700797","https://openalex.org/W2001711719","https://openalex.org/W2001914805","https://openalex.org/W2003363961","https://openalex.org/W2005427302","https://openalex.org/W2005668937","https://openalex.org/W2011181656","https://openalex.org/W2011293778","https://openalex.org/W2018216158","https://openalex.org/W2024596477","https://openalex.org/W2025056130","https://openalex.org/W2027595498","https://openalex.org/W2034584065","https://openalex.org/W2036926504","https://openalex.org/W2039094079","https://openalex.org/W2041519240","https://openalex.org/W2043539107","https://openalex.org/W2043563174","https://openalex.org/W2045058193","https://openalex.org/W2046106422","https://openalex.org/W2050782496","https://openalex.org/W2051966279","https://openalex.org/W2061106767","https://openalex.org/W2062364714","https://openalex.org/W2070488737","https://openalex.org/W2074607560","https://openalex.org/W2074849795","https://openalex.org/W2075733472","https://openalex.org/W2075884689","https://openalex.org/W2080828688","https://openalex.org/W2082382521","https://openalex.org/W2082393868","https://openalex.org/W2085765294","https://openalex.org/W2086337886","https://openalex.org/W2088382174","https://openalex.org/W2089244707","https://openalex.org/W2090451467","https://openalex.org/W2091080694","https://openalex.org/W2095068395","https://openalex.org/W2097585410","https://openalex.org/W2100220373","https://openalex.org/W2114815170","https://openalex.org/W2144078880","https://openalex.org/W2146513771","https://openalex.org/W2156585708","https://openalex.org/W2158717799","https://openalex.org/W2161628453","https://openalex.org/W2162701013","https://openalex.org/W2163762845","https://openalex.org/W2164940559","https://openalex.org/W2169088279","https://openalex.org/W2169846722","https://openalex.org/W2171721120","https://openalex.org/W2186745027","https://openalex.org/W2256830124","https://openalex.org/W2304246816","https://openalex.org/W2313061021","https://openalex.org/W2329929261","https://openalex.org/W2333777284","https://openalex.org/W2406403253","https://openalex.org/W2999510508","https://openalex.org/W3007331336","https://openalex.org/W4248807629"],"related_works":["https://openalex.org/W2741570239","https://openalex.org/W2046106422","https://openalex.org/W2889152502","https://openalex.org/W4399279439","https://openalex.org/W6920278610","https://openalex.org/W48162280","https://openalex.org/W1562224079","https://openalex.org/W2418139356","https://openalex.org/W2804625298","https://openalex.org/W2160499026"],"abstract_inverted_index":{"Os":[0],"corticotrofinomas":[1],"representam":[2],"aproximadamente":[3],"80%":[4],"dos":[5,32,125,133,135],"casos":[6],"de":[7,9,11,47,65,70,82,90,101,147,172,184,190,193],"s\u00edndrome":[8],"Cushing":[10],"origem":[12],"end\u00f3gena":[13],"em":[14,154,158],"adultos.":[15],"Na":[16],"\u00faltima":[17],"d\u00e9cada,":[18],"foram":[19],"feitos":[20],"avan\u00e7os":[21],"consider\u00e1veis":[22],"na":[23,30,39,99,182],"compreens\u00e3o":[24],"do":[25,44,137],"desenvolvimento":[26,189],"da":[27,63,174],"hip\u00f3fise":[28],"anterior,":[29],"patog\u00eanese":[31],"tumores":[33,52,91],"hipofis\u00e1rios":[34],"e":[35,68,80,108,130,140,178,187],"nos":[36],"fatores":[37,71],"envolvidos":[38],"progress\u00e3o":[40],"tumoral.":[41],"A":[42,119],"aplica\u00e7\u00e3o":[43],"conceito":[45],"geral":[46],"tumorig\u00eanese":[48],"\u00e9":[49,150],"adequada":[50],"aos":[51],"corticotr\u00f3ficos,":[53],"sendo":[54,73],"este":[55],"um":[56,114],"processo":[57],"que":[58,152,160],"envolve":[59],"v\u00e1rias":[60],"etapas,":[61],"resultantes":[62],"intera\u00e7\u00e3o":[64],"eventos":[66],"iniciadores":[67],"subseq\u00fcentemente":[69],"promotores,":[72],"portanto":[74],"multifatorial.":[75],"De":[76],"modo":[77],"geral,":[78],"oncogenes":[79],"genes":[81,134,163],"supress\u00e3o":[83],"tumoral":[84,179],"freq\u00fcentemente":[85],"relacionados":[86],"a":[87,113,128,131,145],"outros":[88],"tipos":[89],"n\u00e3o":[92,143],"parecem":[93],"contribuir":[94,181],"neste":[95],"processo,":[96],"embora":[97],"altera\u00e7\u00e3o":[98],"express\u00e3o":[100,132],"alguns":[102],"destes":[103],"genes,":[104],"como":[105],"p53,":[106],"p16":[107],"PTTG,":[109],"possa":[110],"estar":[111,165],"relacionada":[112],"comportamento":[115],"fenot\u00edpico":[116],"mais":[117],"agressivo.":[118],"investiga\u00e7\u00e3o":[120],"das":[121],"vias":[122],"regulat\u00f3rias":[123],"espec\u00edficas":[124],"corticotrofos,":[126],"principalmente":[127],"estrutura":[129],"receptores":[136],"CRH,":[138],"AVP":[139],"GR":[141],"tamb\u00e9m":[142],"evidenciou":[144],"presen\u00e7a":[146],"muta\u00e7\u00f5es.":[148],"Entretanto,":[149],"poss\u00edvel":[151],"altera\u00e7\u00f5es":[153],"regi\u00f5es":[155],"promotoras":[156],"ou":[157],"co-fatores":[159],"regulam":[161],"estes":[162],"possam":[164],"presentes.":[166],"Estudos":[167],"futuros":[168],"sobres":[169],"os":[170],"mecanismos":[171],"regula\u00e7\u00e3o":[173],"c\u00e9lula":[175],"corticotr\u00f3fica":[176],"normal":[177],"dever\u00e3o":[180],"defini\u00e7\u00e3o":[183],"marcadores":[185],"progn\u00f3sticos":[186],"no":[188],"novas":[191],"modalidades":[192],"tratamento.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
