{"id":"https://openalex.org/W2043809773","doi":"https://doi.org/10.1016/j.jchromb.2010.02.023","title":"Determination of methyl-, 2-hydroxyethyl- and 2-cyanoethylmercapturic acids as biomarkers of exposure to alkylating agents in cigarette smoke","display_name":"Determination of methyl-, 2-hydroxyethyl- and 2-cyanoethylmercapturic acids as biomarkers of exposure to alkylating agents in cigarette smoke","publication_year":2010,"publication_date":"2010-02-25","ids":{"openalex":"https://openalex.org/W2043809773","doi":"https://doi.org/10.1016/j.jchromb.2010.02.023","mag":"2043809773","pmid":"https://pubmed.ncbi.nlm.nih.gov/20227354"},"language":"en","primary_location":{"id":"doi:10.1016/j.jchromb.2010.02.023","doi":"https://doi.org/10.1016/j.jchromb.2010.02.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2010.02.023","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038908830","display_name":"Gerhard Scherer","orcid":"https://orcid.org/0000-0001-7456-3402","observed_orcids":["https://orcid.org/0000-0001-7456-3402"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gerhard Scherer","raw_affiliation_strings":["ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany. gerhard.scherer@abf-lab.com","ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany. gerhard.scherer@abf-lab.com","institution_ids":[]},{"raw_affiliation_string":"ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087264992","display_name":"Michael J. Urban","orcid":"https://orcid.org/0000-0001-5077-7043","observed_orcids":["https://orcid.org/0000-0001-5077-7043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Urban","raw_affiliation_strings":["ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111579645","display_name":"Heinz\u2010Werner Hagedorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz-Werner Hagedorn","raw_affiliation_strings":["ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABF Analytisch-Biologisches Forschungslabor M\u00fcnchen GmbH, Goethestrasse 20, 80336 Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009349710","display_name":"Richard Serafin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Serafin","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026842981","display_name":"Shixia Feng","orcid":"https://orcid.org/0000-0002-1780-3438","observed_orcids":["https://orcid.org/0000-0002-1780-3438"]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shixia Feng","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sunil Kapur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Kapur","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045374508","display_name":"Raheema Muhammad","orcid":"https://orcid.org/0000-0003-2872-6797","observed_orcids":["https://orcid.org/0000-0003-2872-6797"]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raheema Muhammad","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Jin","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084821276","display_name":"Mohamadi A. Sarkar","orcid":"https://orcid.org/0000-0002-1167-6140","observed_orcids":["https://orcid.org/0000-0002-1167-6140"]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamadi Sarkar","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068550843","display_name":"Hans\u2010Juergen Roethig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158204","display_name":"Altria (United States)","ror":"https://ror.org/04sme7s65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans-Juergen Roethig","raw_affiliation_strings":["Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altria Client Services, Research, Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I4210158204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038908830"],"corresponding_institution_ids":[],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":0.7895,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.71968709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"878","issue":"27","first_page":"2520","last_page":"2528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.188400000333786,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.060100000351667404,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.8209999799728394},{"id":"https://openalex.org/keywords/biomarkers-of-exposure","display_name":"biomarkers of exposure","score":0.875},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tobacco-smoke","display_name":"tobacco smoke","score":0.4659999907016754},{"id":"https://openalex.org/keywords/n-nitrosodimethylamine","display_name":"N-nitrosodimethylamine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nnk","display_name":"NNK","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ethylene-oxide","display_name":"ethylene oxide","score":0.8500000238418579},{"id":"https://openalex.org/keywords/acrylonitrile","display_name":"acrylonitrile","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.6880000233650208},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/deuterated-internal-standards","display_name":"deuterated internal standards","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pentafluorobenzyl-bromide-derivatization","display_name":"pentafluorobenzyl bromide derivatization","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.929844856262207},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.669396698474884},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6651113033294678},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5840216875076294},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.5292417407035828},{"id":"https://openalex.org/C2777801237","wikidata":"https://www.wikidata.org/wiki/Q407473","display_name":"Ethylene oxide","level":4,"score":0.5182242393493652},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.5118781328201294},{"id":"https://openalex.org/C2778372188","wikidata":"https://www.wikidata.org/wiki/Q342968","display_name":"Acrylonitrile","level":4,"score":0.49160489439964294},{"id":"https://openalex.org/C2778355491","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Tobacco smoke","level":2,"score":0.48044535517692566},{"id":"https://openalex.org/C2776319443","wikidata":"https://www.wikidata.org/wiki/Q421177","display_name":"Cotinine","level":3,"score":0.45184752345085144},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4290464520454407},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.38552939891815186},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.31194308400154114},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2039550244808197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12182760238647461},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07539102435112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000837","descriptor_name":"Anion Exchange Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jchromb.2010.02.023","doi":"https://doi.org/10.1016/j.jchromb.2010.02.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2010.02.023","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},{"id":"pmid:20227354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20227354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W219621047","https://openalex.org/W1586313557","https://openalex.org/W1975338446","https://openalex.org/W1977424782","https://openalex.org/W1981022177","https://openalex.org/W1981969682","https://openalex.org/W1982969180","https://openalex.org/W2014646071","https://openalex.org/W2025067380","https://openalex.org/W2032303437","https://openalex.org/W2051258547","https://openalex.org/W2053024028","https://openalex.org/W2057396508","https://openalex.org/W2065374186","https://openalex.org/W2065739296","https://openalex.org/W2073020277","https://openalex.org/W2076244798","https://openalex.org/W2081796319","https://openalex.org/W2083210511","https://openalex.org/W2094931702","https://openalex.org/W2095619460","https://openalex.org/W2111354267","https://openalex.org/W2122085176","https://openalex.org/W2153582919","https://openalex.org/W2159255062","https://openalex.org/W2170936760","https://openalex.org/W2330591028","https://openalex.org/W2407008905","https://openalex.org/W4239550199"],"related_works":["https://openalex.org/W2009947698","https://openalex.org/W1965285948","https://openalex.org/W2053482447","https://openalex.org/W2052698264","https://openalex.org/W2078669644","https://openalex.org/W2907793018","https://openalex.org/W2042196153","https://openalex.org/W7100827103","https://openalex.org/W4297264513","https://openalex.org/W1988980950"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}