{"id":"https://openalex.org/W2043781493","doi":"https://doi.org/10.1118/1.3182661","title":"TH-D-BRD-07: Nanodosimetry as a Tool for Predicting the RBE of Therapeutic Proton Beams","display_name":"TH-D-BRD-07: Nanodosimetry as a Tool for Predicting the RBE of Therapeutic Proton Beams","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2043781493","doi":"https://doi.org/10.1118/1.3182661","mag":"2043781493"},"language":"en","primary_location":{"id":"doi:10.1118/1.3182661","doi":"https://doi.org/10.1118/1.3182661","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.3182661","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020239394","display_name":"Reinhard W. Schulte","orcid":"https://orcid.org/0000-0002-7892-2756","observed_orcids":["https://orcid.org/0000-0002-7892-2756"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Schulte","raw_affiliation_strings":["Loma Linda University Medical Center, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Loma Linda, CA","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026066992","display_name":"A Wroe","orcid":"https://orcid.org/0009-0009-7943-4816","observed_orcids":["https://orcid.org/0009-0009-7943-4816"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Wroe","raw_affiliation_strings":["Loma Linda University Medical Center, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Loma Linda, CA","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046166092","display_name":"Vladimir A. Bashkirov","orcid":"https://orcid.org/0000-0002-7850-3105","observed_orcids":["https://orcid.org/0000-0002-7850-3105"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Bashkirov","raw_affiliation_strings":["Loma Linda University Medical Center, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Loma Linda, CA","institution_ids":["https://openalex.org/I1293502524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111725414","display_name":"T Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Ling","raw_affiliation_strings":["Saint Louis University, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University, St. Louis, MO","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047224299","display_name":"Baldev R. Patyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Patyal","raw_affiliation_strings":["Loma Linda University Medical Center, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Medical Center, Loma Linda, CA","institution_ids":["https://openalex.org/I1293502524"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1985876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"6Part28","first_page":"2808","last_page":"2809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanodosimetry","display_name":"nanodosimetry","score":0.9950000047683716},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.9729999899864197},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/spread-out-bragg-peak","display_name":"spread-out Bragg peak","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8299999833106995},{"id":"https://openalex.org/keywords/let-dependence","display_name":"LET dependence","score":0.6949999928474426},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/geant4","display_name":"Geant4","score":0.7210000157356262},{"id":"https://openalex.org/keywords/radiobiological-models","display_name":"radiobiological models","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2781298738","wikidata":"https://www.wikidata.org/wiki/Q18041535","display_name":"Sobp","level":4,"score":0.9992042183876038},{"id":"https://openalex.org/C2780944729","wikidata":"https://www.wikidata.org/wiki/Q897227","display_name":"Bragg peak","level":3,"score":0.8761463165283203},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.7735927104949951},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.7689926624298096},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.718246340751648},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.7014057636260986},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5802136063575745},{"id":"https://openalex.org/C30475298","wikidata":"https://www.wikidata.org/wiki/Q909554","display_name":"Computational physics","level":1,"score":0.45726335048675537},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4375573396682739},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.3225005865097046},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.29840850830078125},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15713179111480713},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13113823533058167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09054562449455261}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1118/1.3182661","doi":"https://doi.org/10.1118/1.3182661","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.3182661","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2977342031","https://openalex.org/W7223132323","https://openalex.org/W1976358058","https://openalex.org/W2736190811","https://openalex.org/W2164874555","https://openalex.org/W2103275355","https://openalex.org/W1975425196","https://openalex.org/W3208549150","https://openalex.org/W2030869947","https://openalex.org/W1219278410"],"abstract_inverted_index":{"Purpose:":[0],"One":[1],"of":[2,12,49,55,63,80,85,89,101,129,174,189,196,203,216,222,246,257],"the":[3,9,47,95,127,205,225,235,249,274,280,288,297],"uncertainties":[4],"in":[5,57,224,234,279,287,296],"proton":[6,141,175,187,269],"therapy":[7],"is":[8,17],"depth":[10,255],"dependence":[11,256],"cell":[13,102,134,210],"survival":[14,103,168,211,259],"RBE.":[15],"Nanodosimetry":[16],"an":[18,185,200,213,240],"experimental":[19,35],"gas-based":[20],"technique":[21],"that":[22,273],"can":[23],"also":[24],"be":[25],"simulated":[26,37,50,264],"with":[27],"Monte":[28,161],"Carlo":[29,162],"radiation":[30],"transportation":[31],"codes.":[32],"Agreement":[33],"between":[34],"and":[36,68,108,115,120,228,291],"nanodosimetric":[38,51,75,265],"data":[39,76,266],"has":[40],"previously":[41,71],"been":[42],"presented.":[43],"Here":[44],"we":[45],"explore":[46],"use":[48],"distributions":[52,79,107],"for":[53,132,165,199,208],"prediction":[54],"RBE":[56,131,169,202,207,260,276],"a":[58,148,159,172,194,220,244,268],"spread-out":[59],"Bragg":[60],"peak":[61],"(SOBP)":[62],"200":[64,149],"MeV":[65,150],"protons.":[66],"Method":[67],"Materials:":[69],"A":[70,98],"published":[72],"model":[73,100,121],"converting":[74],"to":[77,113,125,139,158,193,219,231,243],"frequency":[78,106],"double":[81],"strand":[82],"breaks":[83],"(DSBs)":[84],"different":[86,110,145],"complexity":[87],"(number":[88],"associated":[90],"breaks)":[91],"was":[92,118,137,261],"used":[93,138],"as":[94,156,171],"starting":[96],"point.":[97],"radiobiological":[99],"using":[104,263],"these":[105],"assigning":[109],"relative":[111],"lethality":[112],"simple":[114],"complex":[116],"DSBs":[117],"developed":[119],"parameters":[122],"were":[123,177],"chosen":[124],"reproduce":[126],"characteristics":[128],"LET-dependent":[130],"V79":[133,209,258],"survival.":[135],"GEANT4":[136],"calculate":[140],"spectra":[142],"at":[143,179,248],"8":[144],"depths":[146],"within":[147,267],"SOBP":[151,181,226,281],"(3":[152],"cm":[153],"width),":[154],"serving":[155],"input":[157],"dedicated":[160],"simulation":[163],"code":[164],"nanodosimetry.":[166],"Cell":[167],"values":[170],"function":[173],"dose":[176,188,195],"determined":[178],"each":[180],"depth.":[182],"Results:":[183],"With":[184],"SOPB":[186,251],"1.63":[190],"Gy":[191],"(corresponding":[192],"1.8":[197],"GyE":[198],"assumed":[201],"1.1),":[204],"predicted":[206,262,275],"had":[212],"entry":[214],"value":[215,245],"1.23,":[217],"decreasing":[218],"minimum":[221],"1.17":[223],"plateau,":[227,282],"then":[229],"increasing":[230],"about":[232,285],"1.25":[233],"proximal":[236,289],"SOBP,":[237,290],"followed":[238],"by":[239,284,294],"avalanche-type":[241],"increase":[242],"1.39":[247],"distal":[250,298],"end.":[252],"Conclusions:":[253],"The":[254],"SOBP.":[270],"We":[271],"found":[272],"decreased":[277],"slightly":[278],"increased":[283,292],"10%":[286],"steeply":[293],"20%":[295],"SOPB.":[299]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
