{"id":"https://openalex.org/W2043768046","doi":"https://doi.org/10.1007/s11010-006-9363-8","title":"Mechanism of reduced colonic contractility in experimental colitis: role of sarcoplasmic reticulum pump isoform-2","display_name":"Mechanism of reduced colonic contractility in experimental colitis: role of sarcoplasmic reticulum pump isoform-2","publication_year":2006,"publication_date":"2006-11-25","ids":{"openalex":"https://openalex.org/W2043768046","doi":"https://doi.org/10.1007/s11010-006-9363-8","mag":"2043768046","pmid":"https://pubmed.ncbi.nlm.nih.gov/17131044"},"language":"en","primary_location":{"id":"doi:10.1007/s11010-006-9363-8","doi":"https://doi.org/10.1007/s11010-006-9363-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11010-006-9363-8","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113205550","display_name":"Aishah Al\u2010Jarallah","orcid":"https://orcid.org/0000-0002-9723-9178","observed_orcids":["https://orcid.org/0000-0002-9723-9178"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Aisha Al-Jarallah","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Kuwait University, P.O. Box 24923, Jabrya, Safat, 13110, Kuwait","Kuwait University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Kuwait University, P.O. Box 24923, Jabrya, Safat, 13110, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Kuwait University","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112266114","display_name":"Mabayoje Ayotunde Oriowo","orcid":"https://orcid.org/0000-0002-1894-6465","observed_orcids":["https://orcid.org/0000-0002-1894-6465"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Mabayoje A. Oriowo","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Jabrya, Safat, 13110, Kuwait","Kuwait University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Jabrya, Safat, 13110, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Kuwait University","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"last","author":{"id":null,"display_name":"Islam Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Islam Khan","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Kuwait University, P.O. Box 24923, Jabrya, Safat, 13110, Kuwait","Kuwait University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Kuwait University, P.O. Box 24923, Jabrya, Safat, 13110, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Kuwait University","institution_ids":["https://openalex.org/I36721946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36721946"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.345,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82416767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"298","issue":"1-2","first_page":"169","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.09920000284910202,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colonic-contractility","display_name":"colonic contractility","score":0.9419999718666077},{"id":"https://openalex.org/keywords/experimental-colitis","display_name":"experimental colitis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/trinitrobenzene-sulfonic-acid","display_name":"trinitrobenzene sulfonic acid","score":0.8299999833106995},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/serca2","display_name":"SERCA2","score":0.7329999804496765},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-pump","display_name":"sarcoplasmic reticulum Ca2+ pump","score":0.9399999976158142},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/colonic-smooth-muscle","display_name":"colonic smooth muscle","score":0.8709999918937683},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.8619999885559082},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.8974705934524536},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.8502589464187622},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.838894248008728},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.75811767578125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.598442792892456},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5605867505073547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5490263104438782},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.532797634601593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5276880264282227},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.41771912574768066},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.41213545203208923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34675469994544983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21196222305297852},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.12234127521514893},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11269474029541016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0673036277294159}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014302","descriptor_name":"Trinitrobenzenesulfonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11010-006-9363-8","doi":"https://doi.org/10.1007/s11010-006-9363-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11010-006-9363-8","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:17131044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17131044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W78470137","https://openalex.org/W224404621","https://openalex.org/W1503413261","https://openalex.org/W1512410381","https://openalex.org/W1513717105","https://openalex.org/W1518120013","https://openalex.org/W1523941392","https://openalex.org/W1544518972","https://openalex.org/W1552340624","https://openalex.org/W1565034980","https://openalex.org/W1951593821","https://openalex.org/W1983310681","https://openalex.org/W2007058064","https://openalex.org/W2013261296","https://openalex.org/W2013624095","https://openalex.org/W2018289835","https://openalex.org/W2020358486","https://openalex.org/W2027711412","https://openalex.org/W2033444654","https://openalex.org/W2038230509","https://openalex.org/W2039571734","https://openalex.org/W2059133224","https://openalex.org/W2059142969","https://openalex.org/W2060333964","https://openalex.org/W2061094990","https://openalex.org/W2066994490","https://openalex.org/W2079226021","https://openalex.org/W2083325755","https://openalex.org/W2087834892","https://openalex.org/W2088371567","https://openalex.org/W2094934205","https://openalex.org/W2095049902","https://openalex.org/W2099334963","https://openalex.org/W2100837269","https://openalex.org/W2116289754","https://openalex.org/W2119079580","https://openalex.org/W2126974223","https://openalex.org/W2131030147","https://openalex.org/W2144634347","https://openalex.org/W2148614122","https://openalex.org/W2160634724","https://openalex.org/W2337666872","https://openalex.org/W2404512379"],"related_works":["https://openalex.org/W1965720465","https://openalex.org/W3083976277","https://openalex.org/W2059142969","https://openalex.org/W2612792083","https://openalex.org/W2041791844","https://openalex.org/W2055198152","https://openalex.org/W2126974223","https://openalex.org/W78470137","https://openalex.org/W1971127770","https://openalex.org/W28181"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}