{"id":"https://openalex.org/W2043768029","doi":"https://doi.org/10.1210/endo-94-3-845","title":"Effects of Circulating Estradiol During Rat Estrous Cycle on LH Release Following Electrochemical Stimulation of Preoptic Brain or Administration of Synthetic LRF1","display_name":"Effects of Circulating Estradiol During Rat Estrous Cycle on LH Release Following Electrochemical Stimulation of Preoptic Brain or Administration of Synthetic LRF1","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W2043768029","doi":"https://doi.org/10.1210/endo-94-3-845","mag":"2043768029","pmid":"https://pubmed.ncbi.nlm.nih.gov/4591827"},"language":"en","primary_location":{"id":"doi:10.1210/endo-94-3-845","doi":"https://doi.org/10.1210/endo-94-3-845","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-94-3-845","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111391276","display_name":"Satya P. Kalra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SATYA P. KALRA","raw_affiliation_strings":["Department of Obstetrics and Gynecology and Department of Dairy Science, University of Florida Gainesville, Florida 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology and Department of Dairy Science, University of Florida Gainesville, Florida 32610","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047037088","display_name":"Pushpa S. Kalra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PUSHPA S. KALRA","raw_affiliation_strings":["Department of Obstetrics and Gynecology and Department of Dairy Science, University of Florida Gainesville, Florida 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology and Department of Dairy Science, University of Florida Gainesville, Florida 32610","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.122,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90146266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"94","issue":"3","first_page":"845","last_page":"851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9520000219345093},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.9330000281333923},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.9520000219345093},{"id":"https://openalex.org/keywords/medial-preoptic-area","display_name":"medial preoptic area","score":0.9160000085830688},{"id":"https://openalex.org/keywords/electrochemical-stimulation","display_name":"electrochemical stimulation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lh-releasing-factor","display_name":"LH-releasing factor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/luteinizing-hormone-surge","display_name":"luteinizing hormone surge","score":0.7400000095367432},{"id":"https://openalex.org/keywords/proestrus","display_name":"proestrus","score":0.7580000162124634},{"id":"https://openalex.org/keywords/diestrus","display_name":"diestrus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/estrogen-sensitivity","display_name":"estrogen sensitivity","score":0.5400000214576721},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8965504169464111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8885205984115601},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.8525636196136475},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7068158984184265},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.6145668029785156},{"id":"https://openalex.org/C2776451244","wikidata":"https://www.wikidata.org/wiki/Q7240592","display_name":"Preoptic area","level":3,"score":0.5622600317001343},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5277476906776428},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.5202825665473938},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.4912413954734802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4470137655735016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3181496858596802},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2875589430332184}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004971","descriptor_name":"Estrus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-94-3-845","doi":"https://doi.org/10.1210/endo-94-3-845","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-94-3-845","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:4591827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4591827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149745429","https://openalex.org/W2092576156","https://openalex.org/W1974121460","https://openalex.org/W2415026958","https://openalex.org/W2141568409","https://openalex.org/W2035916046","https://openalex.org/W1994677986","https://openalex.org/W2051449666","https://openalex.org/W2088009979","https://openalex.org/W2116308296"],"abstract_inverted_index":{"Serum":[0,18],"levels":[1,65,86,163],"of":[2,57,77,94,112,117,125,143,158,171,174,184,190,203,212,239,285,294,301,325],"estradiol":[3],"(E2)":[4],"and":[5,26,37,109,256,299],"LH":[6,78,89,113,126,137,221,247,271,308],"during":[7,20,43,105,146,318],"the":[8,21,75,101,106,110,118,169,172,213,237,242,257,263,279,313,319],"5-day":[9],"rat":[10],"estrous":[11,107,214,320],"cycle":[12,108],"were":[13,153,164],"determined":[14],"by":[15,48],"radioimmunoassay":[16],"(RIA).":[17],"E2":[19,42,64,85,104,151,162,178,317],"period":[22,173],"between":[23,100],"diestrus":[24,44,147,254],"II":[25,45,81,148,255],"proestrus":[27,58,69,80,95,159,185,191,233,260],"appeared":[28],"to":[29,74,176,287,296,303,305],"rise":[30,39,51],"in":[31,40,135,198,216,219,236,245,281,315],"a":[32,49,226],"biphasic":[33],"manner.":[34],"The":[35,97],"small":[36],"variable":[38],"serum":[41],"was":[46,130,138,229,251],"followed":[47],"marked":[50,196],"(2\u20133-":[52],"fold)":[53],"at":[54,91,181,209,232,253,259,331],"0800":[55],"hr":[56,93,183],"I":[59,70,160,186],"(day":[60,82],"3":[61],"postovulation).":[62,84],"Thereafter":[63],"increased":[66,276],"slowly":[67],"through":[68],"until":[71],"just":[72],"prior":[73],"surge":[76],"on":[79,156],"4":[83],"declined":[87],"asserum":[88],"rose":[90],"1800":[92,182],"II.":[96,234,261],"temporal":[98],"relationship":[99],"circulating":[102,316],"levelsof":[103],"release":[111,272],"after":[114,140,248,273],"electrochemical":[115],"stimulation(EC)":[116],"medial":[119],"preoptic":[120,240,269],"area":[121],"fMPOA)":[122],"or":[123,155,187,206],"administration":[124,202,275],"releasing":[127],"factor":[128],"(LRF)":[129],"next":[131],"studied.":[132],"Minimal":[133],"increase":[134,228,244,280],"plasma":[136,199,220,246,307],"observed":[139],"EC":[141,193,297],"stimulation":[142,194,241,298],"MPOA":[144,295],"either":[145],"when":[149,161],"blood":[150],"values":[152],"low,":[154],"morning":[157],"markedly":[165],"elevated.":[166],"However,":[167],"with":[168,278,312],"extension":[170],"exposure":[175,286],"elevated":[177],"levels,":[179],"i.e.,":[180],"1100":[188],"hrs":[189],"II,":[192],"evoked":[195],"increases":[197,218],"LH.":[200],"Intravenous":[201],"LRF":[204,249,274,304],"(100":[205],"400":[207],"ng/rat)":[208],"all":[210],"phases":[211],"cycleresulted":[215],"significant":[217,230],"15":[222],"min":[223],"later,":[224],"but":[225],"dose-related":[227],"only":[231],"As":[235],"case":[238],"smallest":[243],"injection":[250],"noted":[252],"greatest":[258],"During":[262],"intervening":[264],"period,":[265],"unlike":[266],"that":[267,292,300],"following":[268],"stimulation,":[270],"along":[277],"titer":[282],"and/or":[283],"duration":[284],"E2.":[288],"These":[289],"results":[290],"indicate":[291],"sensitivity":[293],"pituitary":[302],"raise":[306],"is":[309],"closely":[310],"related":[311],"increment":[314],"cycle,":[321],"butthe":[322],"time":[323],"course":[324],"estrogen":[326],"action":[327],"may":[328],"be":[329],"different":[330],"these":[332],"two":[333],"loci.":[334],"(Endocrinology94:":[335],"845,":[336],"1974)":[337]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}